2013
DOI: 10.1007/s00216-012-6624-0
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Recent advances in the development of graphene-based surface plasmon resonance (SPR) interfaces

Abstract: Surface plasmon resonance (SPR) is a powerful technique for measurement of biomolecular interactions in real-time in a label-free environment. One of the most common techniques for plasmon excitation is the Kretschmann configuration, and numerous studies of ligand-analyte interactions have been performed on surfaces functionalized with a variety of biomolecules, for example DNA, RNA, glycans, proteins, and peptides. A significant limitation of SPR is that the substrate must be a thin metal film. Post-coating o… Show more

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Cited by 203 publications
(109 citation statements)
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“…When compared with gold, the plasmon coupling in the silver has a sharper angular resonance peak [12], but it presents a drawback that it can be easily oxidized and the poor chemical stability thus affecting the performance of SPR-sensors [11,12]. Many of methods were designed in an attempt to overcome this problem, for example the use of bimetallic silver-gold layers [13,14], a thin oxide fi lms TiO 2 or SnO 2 [15][16][17], In addition to thin fi lms of carbon such as the amorphous carbon [18], amorphous carbonated silicon (a-Si 0.63 C 0.37 ) [19][20][21] and the newer one is, graphene [13].…”
Section: Introductionmentioning
confidence: 99%
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“…When compared with gold, the plasmon coupling in the silver has a sharper angular resonance peak [12], but it presents a drawback that it can be easily oxidized and the poor chemical stability thus affecting the performance of SPR-sensors [11,12]. Many of methods were designed in an attempt to overcome this problem, for example the use of bimetallic silver-gold layers [13,14], a thin oxide fi lms TiO 2 or SnO 2 [15][16][17], In addition to thin fi lms of carbon such as the amorphous carbon [18], amorphous carbonated silicon (a-Si 0.63 C 0.37 ) [19][20][21] and the newer one is, graphene [13].…”
Section: Introductionmentioning
confidence: 99%
“…This π orbitals form a dense cloud that blocks the gap within its atomic rings. Thus preventing the oxygen from interacting with them [13,[21][22][23]. Further, the graphene layers possesses very fascinating properties include the optical conductivity in the visible-infrared range, the lowest resistivity, high electron mobility, and relatively low cost [1,24,25].…”
Section: Introductionmentioning
confidence: 99%
“…To enhance the sensitivity of SPR sensor, researchers introduced nanomaterials such as chitosan [9,10], zinc oxide [11,12], gold nanoparticle [13,14], graphene [15,16] and graphene oxide [17,18]. Obviously, the employment of those materials results positive responds where the sensitivity of sensors is successfully increased.…”
Section: Introductionmentioning
confidence: 99%
“…The promising potential of SPR sensors is that they are very high sensitivity to a change in the refractive index of the sensing medium [11]. …”
Section: Spr Phenomenonmentioning
confidence: 99%