Recent advances in the structure and biomedical applications of nanodiamonds and their future perspectives

Pan, Feng; Khan, Muhammad Saleem; Ragab, Ahmed H.; Javed, Elisha; Alsalmah, Hessa A.; Khan, Idrees; Lei, Tongfei; Hussain, Amjad; Deifalla, Ahmed Farouk; Zada, Amir; Ansari, Mohd Zahid

doi:10.1016/j.matdes.2023.112179

Cited by 32 publications

(5 citation statements)

References 327 publications

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“…This was performed because the deposited NDs exhibited unsaturated dangling bonds at their surfaces. These dangling bonds could react with oxygen in the air at room temperature once the PF chamber was vented to the atmosphere, and spontaneously form unevenly distributed oxygen-containing groups (C-O-C, C-O or C-OH) to saturate their dangling bonds [71,[73][74][75]. The NTAPJ was used because it generated nonthermal plasma at atmospheric pressure by using an oxygen-working gas [76].…”

Section: Discussionmentioning

confidence: 99%

Effect of nanodiamonds surface deposition on hydrophilicity, bulk degradation and in-vitro cell adhesion of 3D-printed polycaprolactone scaffolds for bone tissue engineering

ElBakry,

Ammar,

Moussa

2024

Biomed. Mater.

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This study was designed to deposit nanodiamonds on 3D-printed PCL scaffolds and evaluate their effect on the surface topography, hydrophilicity, degradation, and in-vitro cell adhesion compared to untreated PCL scaffolds. The PCL scaffold specimens were 3D-printed by fused deposition molding (FDM) technique with specific porosity parameters. The 3D-printed specimens' surfaces were modified by nanodiamonds deposition followed by oxygen plasma post-treatment using a plasma focus (PF) device and a non-thermal atmospheric plasma jet (NTAPJ), respectively. Specimens were evaluated through morphological characterization by field emission scanning electron microscope (FESEM), microstructure characterization by Raman spectroscopy, chemical characterization by Fourier transform infrared (FTIR) spectroscopy, hydrophilicity degree by contact angle and water uptake measurements, and in-vitro degradation measurements (n=6). In addition, in-vitro bone marrow mesenchymal stem cells (BMSCs) adhesion was evaluated quantitatively by Confocal microscopy and qualitatively by FESEM at different time intervals after cell seeding (n=6). The statistical significance level was set at p ≤0.05. The FESEM micrographs, the Raman, and FTIR spectra confirmed the successful surface deposition of nanodiamonds on scaffold specimens. The nanodiamonds treated specimens showed nano-scale features distributed homogeneously across the surface compared to the untreated ones. Also, the nanodiamonds treated specimens revealed a statistically significant smaller contact angle (17.45 ±1.34 degrees), higher water uptake percentage after 24 h immersion in phosphate buffer saline (PBS) (21.56% ±1.73), and higher degradation rate after six months of immersion in PBS (43.92% ±0.77). Moreover, enhanced cell adhesion at all different time intervals was observed in nanodiamonds treated specimens with higher nuclei area fraction percentage (69.87% ±3.97) compared to the untreated specimens (11.46% ±1.34). Surface deposition of nanodiamonds with oxygen-containing functional groups on 3D-printed PCL scaffolds increased their hydrophilicity and degradation rate with significant enhancement of the in-vitro cell adhesion compared to untreated PCL scaffolds.

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Section: Discussionmentioning

confidence: 99%

Effect of nanodiamonds surface deposition on hydrophilicity, bulk degradation and in-vitro cell adhesion of 3D-printed polycaprolactone scaffolds for bone tissue engineering

ElBakry,

Ammar,

Moussa

2024

Biomed. Mater.

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“…A typical magnetic resonance Molecules 2024, 29, 1639 6 of 18 diagnostic approach using nanostructured diamond particles relies on functionalizing the particle surface with covalently grafted lanthanide. Nanosized diamond particles (so-called nanodiamonds) are synthesized in large-scale production via a detonation procedure where a trinitrotoluene and hexogen (TNT/RDX) mixture is detonated under an oxygen-deficient atmosphere [21,23,24]. The isolated detonation nanodiamond (DNDs) particles, reportedly 4-5 nm in diameter size, exhibit both a good metabolic stability, since they are composed of mostly sp 3 -hybridized carbon atoms, and an inherent surface chemistry, with a variety of functional groups which can be oxidized into carboxylic acid functions [20,25].…”

Section: Nanoparticles Of Diamond (Nds)mentioning

confidence: 99%

A Review on the Design of Carbon-Based Nanomaterials as MRI Contrast Agents

Garifo,

Vangijzegem,

Stanicki

et al. 2024

Molecules

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The administration of magnetic resonance imaging (MRI) contrast agents (CAs) has been conducted since 1988 by clinicians to enhance the clarity and interpretability of MR images. CAs based on gadolinium chelates are the clinical standard used worldwide for the diagnosis of various pathologies, such as the detection of brain lesions, the visualization of blood vessels, and the assessment of soft tissue disorders. However, due to ongoing concerns associated with the safety of gadolinium-based contrast agents, considerable efforts have been directed towards developing contrast agents with better relaxivities, reduced toxicity, and eventually combined therapeutic modalities. In this context, grafting (or encapsulating) paramagnetic metals or chelates onto (within) carbon-based nanoparticles is a straightforward approach enabling the production of contrast agents with high relaxivities while providing extensive tuneability regarding the functionalization of the nanoparticles. Here, we provide an overview of the parameters defining the efficacy of lanthanide-based contrast agents and the subsequent developments in the field of nanoparticular-based contrast agents incorporating paramagnetic species.

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“…Recently, there has been an increasing emphasis on non-molecular carbon structures, particularly detonation nanodiamonds (NDs) 3 , 4 . The unique characteristic that distinguishes detonation nanodiamonds from fullerenes and carbon nanotubes is their utilization as a base for metal clusters 5 . Unlike fullerenes and carbon nanotubes, detonation nanodiamonds lack double bonds whose base orbitals could interact with the supported metals 6 .…”

Section: Introductionmentioning

confidence: 99%

Preparation of nanodiamond anchored on copper tannic acid as a heterogenous catalyst for synthesis of 1,4-benzodiazepines derivatives

Ghalavand,

Ghafuri,

Ardeshiri

2024

Sci Rep

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In this research, a new and eco-friendly heterogeneous catalyst (ND@Tannicacid-Cu) was synthesized based on nanodiamond and copper tannic acid via esterification process. The as-prepared catalyst was characterized by Fourier transforms infrared spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), and X-ray diffraction (XRD) methods. The catalytic efficacy of the intended catalyst was examined by one-step three-component reaction of 1,4-benzodiazepine derivatives from a mixture of ortho-phenylenediamine, aromatic aldehydes, and dimedone under mild conditions. In all instances, corresponding 2,4-benzodiazepines derivatives were synthesized with high efficiency, short reaction time, straightforward work up procedure, no requirement for column-chromatography, and cost-effective catalyst. The heterogeneous catalyst was easily recycled using fillers, and it can be reused for eight cycles without significantly diminishing its performance.

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Recent advances in the structure and biomedical applications of nanodiamonds and their future perspectives

Cited by 32 publications

References 327 publications

Effect of nanodiamonds surface deposition on hydrophilicity, bulk degradation and in-vitro cell adhesion of 3D-printed polycaprolactone scaffolds for bone tissue engineering

Effect of nanodiamonds surface deposition on hydrophilicity, bulk degradation and in-vitro cell adhesion of 3D-printed polycaprolactone scaffolds for bone tissue engineering

A Review on the Design of Carbon-Based Nanomaterials as MRI Contrast Agents

Preparation of nanodiamond anchored on copper tannic acid as a heterogenous catalyst for synthesis of 1,4-benzodiazepines derivatives

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