Recent Advances in the Synthesis and Application of C-2-Formyl Glycals

Abstract

Since last couple of decades, C-2-formyl glycals have sustained interest in carbohydrate chemistry as they afford valuable chiral building blocks for many biological / pharmaceutical / industrial based important molecules. Basically, C-2-formyl glycals are a class of carbohydrates incorporating an α,β-unsaturated aldehyde. Therefore in many organic reactions, the C-2-formyl-glycals molecule could therefore serve as an α,β-unsaturated aldehyde core. In this review, we have compiled a literature survey on the synthesis of C-2-formyl-glycals and further their importance for the synthesis of many medicinal, supramolecular, biological, organic as well as material chemistry-based molecules.

Diastereoselective Synthesis of Carbohydrate Conjugates: Pyrano[3,2-c]quinolones

“…19 Unsaturated sugars have a significant position among the many carbohydrate derivatives as starting materials for the synthesis of various organic molecules. 20,21 In continuation of our research to develop newer and efficient methodology for the synthesis of bioactive molecules, [22][23][24] we intend to synthesize diastereoselective pyrano [3,2-c]quinolone carbohydrate conjugates with enhanced bioavailability. After careful assessment of the literature reports, we could comprehend that our desired molecule can be synthesized by annulation of 4-hydroxyquinolones with Perlin aldehyde.…”