Recent advances in the synthesis, functionalization and biomedical applications of hydroxyapatite: a review

Haider, Adnan; Haider, Sajjad; Han, Sung Soo; Kang, Inn Kyu

doi:10.1039/c6ra26124h

Cited by 314 publications

(195 citation statements)

References 132 publications

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“…[8] Calcium phosphate (CaP), the basic ingredient of natural bone, has attracted substantial interest in biomedical applications, such as bone tissue regeneration (osteogenesis), due to its good biodegradability and biocompatibility. [9] Although CaP nanomaterials with different sizes and shapes have been used as nanocarriers of delivery drugs for cancer treatment, hypocrellin derivative-loaded CaP nanorods for NIR light-triggered PDT of cancer still need further investigation. [10] In this work, hypocrellin derivative-loaded CaP nanorods were successfully prepared for natural-product photosensitizer delivery to enhance NIR light-triggered FL imaging and PDT of cancer.…”

Section: Hypocrellin Derivative-loaded Calcium Phosphate Nanorods As mentioning

confidence: 99%

Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

et al. 2019

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Dopamine modified hypocrellin B (DAHB) derivative‐loaded calcium phosphate nanorods (DAHB@CaP NRs) were prepared as a novel phototheranostic agent for effective tumor imaging and therapy. DAHB@CaP NRs were obtained through microwave treatment using DAHB, CaCl2, NH3⋅H2O, and H3PO4 as precursors. The DAHB@CaP NRs possessed the following advantages: 1) efficient absorption in the near‐infrared (NIR) region from 650 nm to 800 nm; 2) maximum NIR emission at approximately 735 nm; 3) enhanced cellular uptake efficiency in vitro and in vivo; and 4) efficient inhibition of tumor growth and low biotoxicity. These properties indicate the high capability of DAHB@CaP NRs for NIR fluorescence (FL) imaging‐guided photodynamic therapy of cancer, thus offering promising new prospects for clinical applications.

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Section: Hypocrellin Derivative-loaded Calcium Phosphate Nanorods As mentioning

confidence: 99%

Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

et al. 2019

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“…Hydroxyapatite (HA) is a material that is widely used in regenerative medicine, bone and dental surgery as it resembles the main inorganic component of mineralised tissues (biological apatite), thus, making it an asset for biomaterial engineering [4,5]. HA is currently considered to be the gold standard in bone tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

A functional apatite with antibacterial efficacy for bone tissue infections

Lim

Tong

Ho³

et al. 2019

J. Phys. Mater.

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Silver, silicon co-substituted hydroxyapatite (Ag, Si-HA) was developed to provide bone repair coupled with antibacterial effect, with the aim to address the problems arise in the treatment of bone tissue infections. In this study, Ag, Si-HA demonstrated substantially reduced attachment of Staphylococcus aureus, Propionibacterium acnes, Escherichia coli, and Pseudomonas aeruginosa as compared to HA at 12 h. Being a prolific opportunistic pathogen in bone tissue infections, we investigated if P. aeruginosa could develop resistance against Ag, Si-HA. Our study showed that despite repeated exposure to fresh population of P. aeruginosa every 48 h, Ag, Si-HA exhibited effective antibacterial properties against the growth of P. aeruginosa over 168 h, indicating low risk of inducing bacterial resistance against Ag, Si-HA. As P. aeruginosa produces exotoxins and harbours endotoxins on its cell call, together these toxins could delay healing process. We therefore examined if the effect of these toxins released by P. aeruginosa during the antibacterial assessment on the attachment of mesenchymal stem cells on HA and Ag, Si-HA. Unlike HA, cell attachment on Ag, Si-HA was not affected by the addition of supernatant obtained from the antibacterial assessment of HA and Ag, Si-HA. This demonstrated that Ag, Si-HA could inhibit the growth of bacteria as well as minimise or prevent the detrimental effect from bacteria toxins.

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“…Since currently one of the main approaches to tissue engineering is bone regeneration, for which it is necessary to consider the production of biocompatible materials with characteristics very similar to bone, which allow cell migration, vascularization, and diffusion of nutrients. 16 Due to the importance of this biomaterial, in the present work, the goal is to obtain HA from a waste by-product of the sea food industry, reducing the contamination made by processing the sea urchin and taking advantage of a raw material that currently is wasted.…”

Section: Introductionmentioning

confidence: 99%

Obtaining hydroxyapatite from the exoskeleton and spines of the purple sea urchin Strongylocentrotus purpuratus

Mancilla‐Sanchez¹,

Gómez‐Gutiérrez²,

Guerra-Rivas

et al. 2018

Int J Applied Ceramic Tech

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We present a simple, quick, and viable way to produce hydroxyapatite (HA) from a waste by-product of the sea food industry, this was achieved by submitting the exoskeleton of the purple sea urchin Strongylocentrotus purpuratus through a chemical reaction with H 3 PO 4 at 3 different times (3, 18, and 36 hours) with constant stirring at 35-40°C. The characterization of the materials was made by several techniques (FTIR, XRD, SEM-EDS, and TEM).The FTIR results confirmed the presence of the HA characteristic functional groups OH, PO 4 , and CO 3 , the XRD characterization showed that the synthesis of calcium phosphates such as brushite and HA was achieved by confirming the presence of its characteristic peaks, also the EDS analysis confirmed the expected HA Ca/P atomic ratio of 1.67. This work shows that we can take advantage from raw materials derived from processing sea food by giving it an added value for the biomedical industry. K E Y W O R D Sbiomaterial, FTIR, hydroxiapatite, sea urchin, Strongylocentrotus purpuratus

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Recent advances in the synthesis, functionalization and biomedical applications of hydroxyapatite: a review

Abstract: Hydroxyapatite (HA) is a member of the Ca apatite family.

Cited by 314 publications

References 132 publications

Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

A functional apatite with antibacterial efficacy for bone tissue infections

Obtaining hydroxyapatite from the exoskeleton and spines of the purple sea urchin Strongylocentrotus purpuratus

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