Recent advances in the transformation reactions of the Betti base derivatives

Olyaei, Abolfazl; Sadeghpour, Mahdieh

doi:10.1039/d4ra01256a

RSC Adv.

2024

DOI: 10.1039/d4ra01256a

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Recent advances in the transformation reactions of the Betti base derivatives

Abolfazl Olyaei,

Mahdieh Sadeghpour

Abstract: This review article highlights the use of Betti base derivatives in transformation reactions for synthesizing organic compounds, particularly heterocyclic molecules, and investigation into their pharmacological properties.

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Cited by 3 publications

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One-Pot, Three-Component Coupling Synthesis of [(Benzothiazol-2-ylamino)(aryl)methyl]isoquinolinols under Catalyst- and Solvent-Free Conditions

Hawsawi,

Gandhamsetty,

Alluhaibi

2024

Synlett

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One-pot three-component coupling procedure has been developed for the synthesis of (2'-aminobenzothiazolomethyl-aryl)-hydroxyisoquinolines via the reaction of hydroxyisoquinolines, aryl/heteroaryl/aliphatic aldehydes with 2-aminobenzothiazoles under catalyst- and solvent-free conditions. The developed 2'-aminobenzothiazolomethylation procedure is suitable to execute even on gram scale with a broad scope. The 2'-aminobenzothiazolomethylated products (Betti bases) were formed through the initial nucleophilic C-attack of hydroxyisoquinolines on aldehydes to generate the ortho-Quinone Methide (o-QM) as an intermediate followed by the subsequent 1,4-aza-Michael addition of 2-aminobenzothiazoles. Betti bases have significance in medicinal chemistry due to their wide range of pharmacological applications and they are useful ligands and catalysts in asymmetric synthesis.

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Recent advances in the transformation reactions of the Betti base derivatives

Abstract: This review article highlights the use of Betti base derivatives in transformation reactions for synthesizing organic compounds, particularly heterocyclic molecules, and investigation into their pharmacological properties.

Cited by 3 publications

References 87 publications

Apigenin analogs as α-glucosidase inhibitors: Molecular docking, biochemical, enzyme kinetic, and an in vivo mouse model study

Apigenin analogs as α-glucosidase inhibitors: Molecular docking, biochemical, enzyme kinetic, and an in vivo mouse model study

Synthesis of 1,3-oxazines based on piperazine

One-Pot, Three-Component Coupling Synthesis of [(Benzothiazol-2-ylamino)(aryl)methyl]isoquinolinols under Catalyst- and Solvent-Free Conditions

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