Recent advances in the treatment of advanced colorectal cancer

Kemeny, Nancy E.; Lokich, Jacob J.; Anderson, Norwood; Ahlgren, James D.

doi:10.1002/1097-0142(19930101)71:1<9::aid-cncr2820710104>3.0.co;2-y

Cited by 63 publications

(19 citation statements)

References 45 publications

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“…However, the local effectiveness based on the rate of local recurrences was higher in patients with HCC vs the patients with metastases, in HCC local tumour control was 70% and in CRLM only 26%. The response in CRLM is comparable with these after systemic chemotherapy which mainly remains below 30% (Kemeny et al, 1993). For the HCC our results are comparable to these after chemoembolization or hepatic arterial infusion, a response of 30 -60% after TACE (Takayasu et al, 1989;GTCH 1995;Colella et al, 1998) and 40 -50% after HAI (Carr, 1996;Patt et al, 1997) is reported.…”

Section: Discussionsupporting

confidence: 81%

CT-guided intratumoural administration of cisplatin/epinephrine gel for treatment of malignant liver tumours

et al. 2002

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To analyze prospectively the interventional and clinical aspects of computed tomography-guided direct intratumoural injection of a novel chemotherapeutic administration and the parenchymal changes of tumour and necrosis in malignant liver tumours. Eight patients with 17 colorectal liver metastases were treated with a mean of 5.1 injections and nine patients with 13 hepatocellular carcinoma nodules with a mean of 3.1 treatments with computed tomography guided local applications of a novel cisplatin/epinephrine gel. This application provides a higher local and lower systemic drug concentration. Volumes of tumour and necrosis prior and after treatment were measured by computer generated volumetric analysis. Contrast enhanced studies verified pretherapeutic viable tumour volumes with a value of 77.4 ml in the metastases and 29.2 ml in the hepatocellular carcinoma nodules. Intratumoural drug application resulted in a significant increase of necrosis and a decrease in viable tumour volume to be 68.3 ml in metastases and 14.5 ml in hepatocellular carcinoma. Local therapy control rate for the follow up to 6 months was 38 and 71% for the group of metastases and hepatocellular carcinoma, respectively. Direct intratumoural injection of cisplatin/epinepthrine injectable gel is a feasible and good tolerated method and results in the development of a statistically significant increase in necrosis in malignant liver tumours. For hepatocellular carcinoma a higher local therapy control rate compared to colorectal metastases can be reported.

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Section: Discussionsupporting

confidence: 81%

CT-guided intratumoural administration of cisplatin/epinephrine gel for treatment of malignant liver tumours

et al. 2002

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“…The above results indicate that the therapy after recurrence contributed to prolonging life. In this connection, the following situations can be pointed out: good prognosis after resection for recurrences, which has recently begun to achieve positive results [25,26,27,28,29,30,31,32] and an improvement in chemotherapy, including loco-regional chemotherapy, using liver arterial infusion for progressive recurrent cancer.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of oral UFT as adjuvant chemotherapy to curative resection of colorectal cancer: multicenter prospective randomized trial

Kato

Ohashi

Nakazato³

et al. 2002

Langenbeck’s Arch Surg

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“…Despite overall 5-year survival rates of only 25 to 40%, surgical resection remains the treatment of choice for appropriately selected patients (2,3). The most common therapeutic modality used in patients presenting with colorectal hepatic metastases is systemic chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Liposomal Irinotecan

Messerer

Ramsay

Waterhouse

et al. 2004

Clinical Cancer Research

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Purpose:The purpose is to demonstrate whether an appropriately designed liposomal formulation of irinotecan is effective in treating mice with liver-localized colorectal carcinomas.Experimental Design: Irinotecan was encapsulated in 1,2-distearoyl-sn-glycero-3-phosphocholine/cholesterol (55:45 molar ratio) liposomes using an ionophore (A23187)-generated transmembrane proton gradient. This formulation was evaluated in vivo by measuring plasma elimination of liposomal lipid and drug after i.v. administration. Therapeutic activity was determined in SCID/Rag-2M mice bearing s.c. LS180 tumors or orthotopic LS174T colorectal metastases.Results: Drug elimination from the plasma was significantly reduced when irinotecan was administered in the liposomal formulation. At 1 hour after i.v. administration, circulating levels of the liposomal drug were 100-fold greater than that of irinotecan given at the same dose. High-performance liquid chromatographic analysis of plasma samples indicated that liposomal irinotecan was protected from inactivating hydrolysis to the carboxylate form. This formulation exhibited substantially improved therapeutic effects. For the LS180 solid tumor model, it was shown that after a single injection of liposomal irinotecan at 50 mg/kg, the time to progress to a 400-mg tumor was 34 days (as compared with 22 days for animals treated with free drug at an equivalent dose). In the model of colorectal liver metastases (LS174T), a median survival time of 79 days was observed after treatment with liposomal irinotecan (50 mg/kg, given every 4 days for a total of three doses). Saline and free drug treated mice survived for 34 and 53 days, respectively.Conclusions: These results illustrate that liposomal encapsulation can substantially enhance the therapeutic activity of irinotecan and emphasize the potential for using liposomal irinotecan to treat liver metastases.

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Recent advances in the treatment of advanced colorectal cancer

Cited by 63 publications

References 45 publications

CT-guided intratumoural administration of cisplatin/epinephrine gel for treatment of malignant liver tumours

CT-guided intratumoural administration of cisplatin/epinephrine gel for treatment of malignant liver tumours

Efficacy of oral UFT as adjuvant chemotherapy to curative resection of colorectal cancer: multicenter prospective randomized trial

Liposomal Irinotecan

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