Recent advances of electrochemical sensors for detecting and monitoring ROS/RNS

Zhao, Shuang; Zang, Guangchao; Liu, Huawen; Wang, Nan; Cai, Shangjun; Durkan, Colm; Xie, Guoming; Wang, Guixue

doi:10.1016/j.bios.2021.113052

Cited by 79 publications

(38 citation statements)

References 243 publications

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“…In addition, with the emergence of nanomaterials, nanotechnology has greatly promoted the development of in vivo electrochemistry. 134 At present, electrochemical biosensors for in vivo detection of ROS have also been developed. Such sensors have real-time detection, low cost, 135 and rapid response., high sensitivity and selectivity.…”

Section: Discussionmentioning

confidence: 99%

Echem methods and electrode types of the current in vivo electrochemical sensing

Song

Yan

et al. 2022

RSC Adv.

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Section: Discussionmentioning

confidence: 99%

Echem methods and electrode types of the current in vivo electrochemical sensing

Song

Yan

et al. 2022

RSC Adv.

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“…ROS or oxidants can be classified as free radicals and major physiologically relevant ROS, including superoxide anions (O 2 •− ), hydroxyl radicals (•OH), and hydrogen peroxide (H 2 O 2 ). The imbalance between oxidants and antioxidants induces the oxidative stress [ 17 ]. Under conditions of normal antioxidant homeostasis, cells can effectively remove physiological ROS through protection systems consisting of enzymatic and nonenzymatic components.…”

Section: Ros Production and Oxidative Stress In The Development Of Nafldmentioning

confidence: 99%

The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD

Hong

Chen

et al. 2021

Oxidative Medicine and Cellular Longevity

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The overproduction of reactive oxygen species (ROS) and consequent oxidative stress contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged that nonalcoholic fatty liver disease (NAFLD) is characterized as a redox-centered disease due to the role of ROS in hepatic metabolism. However, the underlying mechanisms accounting for these alternations are not completely understood. Several nuclear receptors (NRs) are dysregulated in NAFLD, and have a direct influence on the expression of a set of genes relating to the progress of hepatic lipid homeostasis and ROS generation. Meanwhile, the NRs act as redox sensors in response to metabolic stress. Therefore, targeting NRs may represent a promising strategy for improving oxidation damage and treating NAFLD. This review summarizes the link between impaired lipid metabolism and oxidative stress and highlights some NRs involved in regulating oxidant/antioxidant turnover in the context of NAFLD, shedding light on potential therapies based on NR-mediated modulation of ROS generation and lipid accumulation.

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“…AS sensors have been widely used in many fields, including environmental monitoring [1], food safety [2] and medical diagnostics [3]. Commonly used gas sensors are based on semiconducting [4], electrochemical [5] and biosensing principles [6]. However, the sensitivity and/or LoD (Limit of Detection) of many kinds of gas sensors is not sufficient for some applications, requiring more sophisticated analytical techniques to be used [7,8].…”

Section: Introductionmentioning

confidence: 99%