Recent Advances of Low Biological Toxicity Ag<sub>2</sub>S QDs for Biomedical Application

Lu, Chenghao; Chen, Guihuan; Yu, Bing; Cong, Hailin

doi:10.1002/adem.201700940

Cited by 68 publications

(30 citation statements)

References 89 publications

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“…In addition to Au nanocrystals and their assemblies, transition‐metal chalcogenides/MXene‐based nanomaterials have also been widely used as PA‐imaging agents . For example, Cheng et al designed PEGylated tungsten disulfide (WS 2 ‐PEG) ( Figure A) that could act as a PA‐imaging contrast agent of tumors, as well as being a highly effective photothermal agent due to its excellent NIR absorbance .…”

Section: Inorganic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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Photoacoustic (PA) imaging as a fast‐developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light‐absorption coefficient of the imaged tissue and the injected PA‐imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA‐imaging contrast agents are developed to improve the PA‐imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA‐imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA‐imaging contrast agents and their significance in biomedical research is presented.

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Section: Inorganic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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“…In our previous study, the reduced scattering of NIR−II QD signals made the imaging depth in skin tissues three times deeper than QDs emitting at 800 nm which is at the conventional first near infrared (NIR−I, 650–950 nm) window under an equivalent imaging condition as for the NIR−II QDs . Ag 2 S QDs can emit at NIR−II and are composed of less toxic elements than other NIR−II emitting QDs such as PbS, PbSe, InAs, Cd 3 As 2 , HgS, and HgSe, which offers great biocompatibility . Synthesis strategies for NIR−II emitting Ag 2 S QDs has been studied well, but the incorporation procedure of metal ions into Ag 2 S nanounit is not fully interrogated.…”

Section: Figurementioning

confidence: 99%

“…[12] Ag 2 S QDs can emit at NIRÀ II and are composed of less toxic elements than other NIRÀ II emitting QDs such as PbS, PbSe, InAs, Cd 3 As 2 , HgS, and HgSe, which offers great biocompatibility. [14][15][16] Synthesis strategies for NIRÀ II emitting Ag 2 S QDs has been studied well, [17][18][19][20][21][22] but the incorporation procedure of metal ions into Ag 2 S nanounit is not fully interrogated. Magnetic transition metal doped NIRÀ II emitting Ag 2 S QDs can offer great opportunities for dual imaging modality combining NIRÀ II optical imaging and T 1 -weighted MRI.…”

mentioning

confidence: 99%

Colloidal Second Near‐Infrared‐Emitting Mn‐Doped Ag₂S Quantum Dots

2020

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Incorporation of transition metal dopants within a semiconductor nanocrystal has a tremendous effect on the optical and magnetic properties of the semiconductor nanocrystals. Herein, we report on a novel synthesis of second near‐infrared‐emitting photoluminescent Mn2+‐doped Ag2S quantum dots via co‐pyrolysis of silver and manganese single‐source precursors. The Mn2+ doping level was flexibly tuned in Ag2S quantum dots, which was confirmed by elemental analysis and electron paramagnetic resonance spectroscopy. The Mn2+ doping induced negligible change in the pristine monoclinic acanthite Ag2S crystal structure but significantly decreased the photoluminescent intensity. Mn2+‐doped Ag2S QDs exhibit second near‐infrared emission and ferromagnetic ordering, which show the potential applicability for multimodal fluorescence/MRI probes.

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“…As one of the NIR fluorescent nanomaterials, Ag 2 S nanodots (NDs) have been used in biosensors and for bioimaging due to their unique properties. [ 35 ] Our group reported the preparation of 3‐MPA stabilized Ag 2 S NDs and their application in the detection of fluorine ions in living cells and pH in tumor‐bearing zebrafish. [ 36,37 ] Recently, we developed an approach for the synthesis of aptamer‐modified Ag 2 S NDs for the specific recognition of CTCs using a one‐pot route under mild condition.…”

Section: Introductionmentioning

confidence: 99%

Multivalent Aptamer Functionalized Ag₂S Nanodots/Hybrid Cell Membrane‐Coated Magnetic Nanobioprobe for the Ultrasensitive Isolation and Detection of Circulating Tumor Cells

Ding

Zhang

Cheng

2020

Adv Funct Materials

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Circulating tumor cells (CTCs) play key roles in the development of tumor metastasis. It remains a significant challenge to capture and detect CTCs with high purity and sensitivity from blood samples. Herein, a nanoplatform is developed for the efficient isolation and ultrasensitive detection of CTCs by combining near-infrared (NIR) multivalent aptamer functionalized Ag 2 S nanodots with hybrid cell membrane-coated magnetic nanoparticles. Multivalent aptamer functionalized Ag 2 S nanodots are synthesized using a one-pot method under mild conditions (60 °C). White blood cell and tumor cell membranes are fused as the hybrid membrane and coated with magnetic nanoparticles, which are further modified with streptavidin (SA). Through the specific interaction of SA-biotin, the multivalent aptamer-Ag 2 S nanodots are grafted with hybrid cell membrane-magnetic nanoparticles. Due to the features of hybrid cell membrane modification, multivalent aptamer functionalization, magnetic separation, and NIR fluorescence measurements, the nanoplatform shows sensitive recognition, efficient capture, easy isolation, and sensitive detection of CTCs due to its great enhancement in anti-interference from background and improvement on binding ability toward CTCs. The capture efficiency and purity for CTCs is as high as 97.63% and 96.96%, respectively. Furthermore, the nanoplatform is successfully applied to the detection of CTCs in blood samples.

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Recent Advances of Low Biological Toxicity Ag₂S QDs for Biomedical Application

Cited by 68 publications

References 89 publications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Colloidal Second Near‐Infrared‐Emitting Mn‐Doped Ag₂S Quantum Dots

Multivalent Aptamer Functionalized Ag₂S Nanodots/Hybrid Cell Membrane‐Coated Magnetic Nanobioprobe for the Ultrasensitive Isolation and Detection of Circulating Tumor Cells

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Recent Advances of Low Biological Toxicity Ag2S QDs for Biomedical Application

Cited by 68 publications

References 89 publications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Colloidal Second Near‐Infrared‐Emitting Mn‐Doped Ag2S Quantum Dots

Multivalent Aptamer Functionalized Ag2S Nanodots/Hybrid Cell Membrane‐Coated Magnetic Nanobioprobe for the Ultrasensitive Isolation and Detection of Circulating Tumor Cells

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Product

Resources

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Recent Advances of Low Biological Toxicity Ag₂S QDs for Biomedical Application

Colloidal Second Near‐Infrared‐Emitting Mn‐Doped Ag₂S Quantum Dots

Multivalent Aptamer Functionalized Ag₂S Nanodots/Hybrid Cell Membrane‐Coated Magnetic Nanobioprobe for the Ultrasensitive Isolation and Detection of Circulating Tumor Cells