Recent advances of polymer based nanosystems in cancer management

Janrao, Chetan; Khopade, Shivani; Bavaskar, Akshay; Gomte, Shyam Sudhakar; Agnihotri, Tejas Girish; Jain, Aakanchha

doi:10.1080/09205063.2022.2161780

Cited by 15 publications

(5 citation statements)

References 331 publications

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“…As drug delivery carriers, biodegradable polyesters have many good properties, such as increasing the solubility of hydrophobic drugs, improving drug efficacy, prolonging drug action time, and improving drug bioavailability (Janrao et al, 2023). This review summarizes the recent applications of biodegradable polyester-based nano-drug delivery systems over the past 3 years.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)

Wang,

Xiao,

Guo

et al. 2023

Front. Bioeng. Biotechnol.

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Cancer presents a formidable threat to human health, with the majority of cases currently lacking a complete cure. Frequently, chemotherapy drugs are required to impede its progression. However, these drugs frequently suffer from drawbacks such as poor selectivity, limited water solubility, low bioavailability, and a propensity for causing organ toxicity. Consequently, a concerted effort has been made to seek improved drug delivery systems. Nano-drug delivery systems based on biodegradable polyesters have emerged as a subject of widespread interest in this pursuit. Extensive research has demonstrated their potential for offering high bioavailability, effective encapsulation, controlled release, and minimal toxicity. Notably, poly (ε-caprolactone) (PCL), poly (lactic-co-glycolic acid) (PLGA), and polylactic acid (PLA) have gained prominence as the most widely utilized options as carriers of the nano drug delivery system. This paper comprehensively reviews recent research on these materials as nano-carriers for delivering chemotherapeutic drugs, summarizing their latest advancements, acknowledging their limitations, and forecasting future research directions.

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Section: Discussionmentioning

confidence: 99%

Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)

Wang,

Xiao,

Guo

et al. 2023

Front. Bioeng. Biotechnol.

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“…The surface modification of nanoparticles with either PEG or polyethylene oxide also takes into account a longer nanoparticle dispersion time by reducing opsonic bond and opsonization, which consequently reduces nanoparticle recognition by RES ( 136 ). Finally, this increases the aggregation of nanoparticles in solid tumors, as demonstrated by the covert PEG-related liposomes loaded with doxorubicin (Doxil) and poly(ethylene oxide)-altered poly(caprolactone) nanoparticles containing tamoxifen ( 137 ). Dynamic focusing on the cycle may then occur after uninvolved focusing is complete, more specifically after the conveyance framework has accumulated inactively inside the tumor site.…”

Section: Tumor Targeting Of Lbnpsmentioning

confidence: 99%

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Waheed,

Ali,

Tabassum

et al. 2024

Front. Oncol.

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Cancer is a severe disease that results in death in all countries of the world. A nano-based drug delivery approach is the best alternative, directly targeting cancer tumor cells with improved drug cellular uptake. Different types of nanoparticle-based drug carriers are advanced for the treatment of cancer, and to increase the therapeutic effectiveness and safety of cancer therapy, many substances have been looked into as drug carriers. Lipid-based nanoparticles (LBNPs) have significantly attracted interest recently. These natural biomolecules that alternate to other polymers are frequently recycled in medicine due to their amphipathic properties. Lipid nanoparticles typically provide a variety of benefits, including biocompatibility and biodegradability. This review covers different classes of LBNPs, including their characterization and different synthesis technologies. This review discusses the most significant advancements in lipid nanoparticle technology and their use in medicine administration. Moreover, the review also emphasized the applications of lipid nanoparticles that are used in different cancer treatment types.

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“…From a biological perspective, polymer-based molecules possess several advantageous characteristics. These nanoparticles can conjugate, adsorb, capture, or encapsulate anticancer agents, including hydrophilic and lipophilic drugs, monoclonal antibodies, and genes, among others, for controlled release, tumor targeting (active/passive), protection under physiological conditions, and enhanced tumor uptake [153].…”

Section: Polymer-based Nanoparticlesmentioning

confidence: 99%

Nanotechnology as a Promising Method in the Treatment of Skin Cancer

Adamus-Grabicka,

Hikisz,

Sikora

2024

IJMS

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The incidence of skin cancer continues to grow. There are an estimated 1.5 million new cases each year, of which nearly 350,000 are melanoma, which is often fatal. Treatment is challenging and often ineffective, with conventional chemotherapy playing a limited role in this context. These disadvantages can be overcome by the use of nanoparticles and may allow for the early detection and monitoring of neoplastic changes and determining the effectiveness of treatment. This article briefly reviews the present understanding of the characteristics of skin cancers, their epidemiology, and risk factors. It also outlines the possibilities of using nanotechnology, especially nanoparticles, for the transport of medicinal substances. Research over the previous decade on carriers of active substances indicates that drugs can be delivered more accurately to the tumor site, resulting in higher therapeutic efficacy. The article describes the application of liposomes, carbon nanotubes, metal nanoparticles, and polymer nanoparticles in existing therapies. It discusses the challenges encountered in nanoparticle therapy and the possibilities of improving their performance. Undoubtedly, the use of nanoparticles is a promising method that can help in the fight against skin cancer.

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Recent advances of polymer based nanosystems in cancer management

Cited by 15 publications

References 331 publications

Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)

Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Nanotechnology as a Promising Method in the Treatment of Skin Cancer

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