Recent advances of redox-responsive nanoplatforms for tumor theranostics

Chen, Miaomiao; Liu, Dapeng; Liu, Fusheng; Wu, Yingnan; Peng, Xiaojun; Song, Fengling

doi:10.1016/j.jconrel.2021.02.030

Cited by 108 publications

(77 citation statements)

References 111 publications

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“…[135][136][137] Different from the conventional procedure of introducing heavy-metal atoms into PSs to improve the ISC process which could potentially induce intrinsic toxicity and undesirable degradation concerns, [133,[138][139][140][141] the TADF emitters as one of purely organic PSs have aroused growing interest in PDT owing to its fascinating properties especially the metal-free highperformance photosensitizing ability. [142][143][144][145][146] As proof of concept, for the first time, our group proposed water-dispersible TADF NPs with small ΔE ST as a novel metalfree organic PS for photo-excited 1 O 2 formation in 2016. [25] Considering the limitations of unsatisfactory 1 O 2 quantum yield, poor optical penetration depth, and lack of organelle targeting, we further designed the two-photon-excited (TPE) anthraquinone derivatives-based TADF NPs (An-TPA NPs and An-Cz-Ph NPs) with favorable 1 O 2 quantum yield up to 52% as well as inherently mitochondria targeting capability (Figure 12a).…”

Section: O 2 Generation For Pdtmentioning

confidence: 99%

“…[ 135 , 136 , 137 ] Different from the conventional procedure of introducing heavy‐metal atoms into PSs to improve the ISC process which could potentially induce intrinsic toxicity and undesirable degradation concerns, [ 133 , 138 , 139 , 140 , 141 ] the TADF emitters as one of purely organic PSs have aroused growing interest in PDT owing to its fascinating properties especially the metal‐free high‐performance photosensitizing ability. [ 142 , 143 , 144 , 145 , 146 ]…”

Section: Tadf Materials For Biomedical Applicationsmentioning

confidence: 99%

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Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

et al. 2021

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The development of simple, efficient, and biocompatible organic luminescent molecules is of great significance to the clinical transformation of biomaterials. In recent years, purely organic thermally activated delayed fluorescence (TADF) materials with an extremely small single-triplet energy gap (𝚫E ST ) have been considered as the most promising new-generation electroluminescence emitters, which is an enormous breakthrough in organic optoelectronics. By merits of the unique photophysical properties, high structure flexibility, and reduced health risks, such metal-free TADF luminophores have attracted tremendous attention in biomedical fields, including conventional fluorescence imaging, time-resolved imaging and sensing, and photodynamic therapy. However, there is currently no systematic summary of the TADF materials for biomedical applications, which is presented in this review. Besides a brief introduction of the major developments of TADF material, the typical TADF mechanisms and fundamental principles on design strategies of TADF molecules and nanomaterials are subsequently described. Importantly, a specific emphasis is placed on the discussion of TADF materials for various biomedical applications. Finally, the authors make a forecast of the remaining challenges and future developments. This review provides insightful perspectives and clear prospects towards the rapid development of TADF materials in biomedicine, which will be highly valuable to exploit new luminescent materials.

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Section: O 2 Generation For Pdtmentioning

confidence: 99%

Section: Tadf Materials For Biomedical Applicationsmentioning

confidence: 99%

Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

et al. 2021

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“…However, there are different conditions where theranostics based on ROS were implemented. For example, a nanotheranostics system based on boronated maltodextrin works by releasing 4-hydroxybenzyl alcohol in the presence of H2O2 and generate carbon dioxide bubbles for ultrasound imaging due to its echogenic properties [57].…”

Section: C) Ros Responsive Nanotheranosticsmentioning

confidence: 99%

Nanotheranostics-An Emerging Technique in Nanomedicine

Khan

2021

AJBSR

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Nanotheranostics is a novel yet developing field which promises advanced methods for clinical diagnostics and treatment. Certain biological molecules present inside human body and their varying concentrations are used as detectable signals for nanoparticles or nanoconjugates to identify cancerous or tumors cells and also targeting these effected cells for the treatment of disease. At present, available treatments are expensive, time consuming with potential side effects. Therefore, application of nanotheranostics will surely help to minimize such issues and promises better therapeutics in nanomedicine

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“…Encouragingly, a recent breakthrough in the development of thermally activated delayed fluorescence (TADF) materials in the field of organic light‐emitting diodes opens new opportunities for exploring metal‐free PSs with intriguing photochemical properties. [ 22–29 ] With an extremely small singlet‐triplet energy gap (Δ E ST ), the energy conversion between S 1 and T 1 states in PSs could be easily accessed in the TADF emitters, which can realize the efficient ISC for high‐performance PDT. [ 30,31 ] During the past few years, an increasing number of TADF emitters with narrow Δ E ST have been utilized as robust PSs for 1 O 2 generation.…”

Section: Introductionmentioning

confidence: 99%

Near‐Infrared Thermally Activated Delayed Fluorescence Nanoparticle: A Metal‐Free Photosensitizer for Two‐Photon‐Activated Photodynamic Therapy at the Cell and Small Animal Levels

Fang

Yuan

Wan

et al. 2022

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Thermally activated delayed fluorescence (TADF) materials with extremely small singlet‐triplet energy offsets have opened new horizons for the development of metal‐free photosensitizers for photodynamic therapy (PDT) in recent years. However, the exploration of near‐infrared (NIR) TADF emitters for efficient two‐photon‐excited (TPE) PDT is still a formidable challenge, thus it has not been reported yet. In this study, purely organic photosensitizers (PSs) based on the TADF nanoparticles (NIR‐TADF NPs) are designed for efficient TPE‐PDT, which show excellent singlet oxygen generation ability. Thanks to the intrinsic two‐photon excitation and NIR emission characteristics, the NIR‐TADF NPs demonstrate promising potential in both single‐photon‐excited (SPE) and TPE NIR imaging. More importantly, the anti‐tumor efficiency and biosafety of TADF‐based PSs at the small animal level are confirmed in A549 tumor xenograft models under TPE laser irradiance, which will facilitate the practical biomedical applications of TADF materials. This work not only provides a promising strategy to develop metal‐free PSs, but also expands the applied scope of TADF‐based nanotherapeutics and advances their possible clinical translation in cancer therapy.

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Recent advances of redox-responsive nanoplatforms for tumor theranostics

Cited by 108 publications

References 111 publications

Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

Nanotheranostics-An Emerging Technique in Nanomedicine

Near‐Infrared Thermally Activated Delayed Fluorescence Nanoparticle: A Metal‐Free Photosensitizer for Two‐Photon‐Activated Photodynamic Therapy at the Cell and Small Animal Levels

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