Recent advances of sonodynamic therapy in cancer treatment

Wan, Guoyun; Liu, Yang; Chen, Bo-Wei; Liu, Yuan-Yuan; Wang, Yinsong; Zhang, Ning

doi:10.20892/j.issn.2095-3941.2016.0068

Cited by 235 publications

(166 citation statements)

References 83 publications

Supporting

Mentioning

161

Contrasting

Order By: Relevance

“…The result is a mechanical damage and a consequent induction of cell death by the so called "mechanical pathway" from refs. [88,105], as also depicted in Fig. 3.…”

Section: G Canavese Et Alsupporting

confidence: 57%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

351

247

View full text Add to dashboard Cite

• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

show abstract

“…The result is a mechanical damage and a consequent induction of cell death by the so called "mechanical pathway" from refs. [88,105], as also depicted in Fig. 3.…”

Section: G Canavese Et Alsupporting

confidence: 57%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

351

247

View full text Add to dashboard Cite

show abstract

“…Previous studies have reported that different ultrasonic intensities combined with diverse sound-sensitive agents produce distinct biological effects on specialized cells and tissues [26][27][28]. In this study, we demonstrated that when DVDMS was used in conjunction with ultrasound (diameter: 3.5 cm; resonance frequency: 0.5 MHz; duty factor: 10%; repetition frequency: 100 Hz) on the SCLC H446 cell line, apoptosis was observed.…”

Section: Discussionsupporting

confidence: 51%

Sinoporphyrin Sodium-Mediated Sonodynamic Therapy Inhibits RIP3 Expression and Induces Apoptosis in the H446 Small Cell Lung Cancer Cell Line

Shen

Cao

Sun

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Sonodynamic therapy (SDT) is expected to be a new method to solve the clinical problems caused by advanced metastasis in patients with lung cancer. The use of ultrasound has the advantage of being noninvasive, with deep-penetration properties. This study explored the anti-tumor effect of SDT with a new sonosensitizer, sinoporphyrin sodium (DVDMS), on the human small cell lung cancer H446 cell line in vitro and in vivo. Methods: Absorption of DVDMS was detected by a fluorescence spectrophotometer, and DVDMS toxicity was determined using a Cell Counting Kit-8. Mitochondrial membrane potential (MMP) was assessed using the JC-1 fluorescent probe. Cell apoptosis was measured by flow cytometry, and apoptosis-related proteins were detected by western blotting. The expression of cytokines was measured using an enzyme-linked immunosorbent assay and quantitative real-time PCR. To verify the in vitro results, we detected tumor volumes and weight changes in a xenograft nude mouse model after DVDMS-SDT. Hematoxylin and eosin staining was used to observe changes to the tumor, heart, liver, spleen, lung, and kidney of the mice, and immunohistochemistry was used to examine changes in the expression of tumor CD34 and receptor-interacting protein kinase-3 (RIP3), while terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling was used to observe apoptosis in tumor tissues. Results: DVDMS-SDT-treated H446 cells increased the rate of cellular apoptosis and the levels of reactive oxygen species (ROS), cleaved caspase-3, cleaved caspase-8, cleaved caspase-9, and caspase-10, and decreased the levels of MMP, RIP3, B-cell lymphoma 2, vascular endothelial growth factor, and tumor necrosis factor-α. The sonotoxic effect was mediated by ROS and was reduced by a ROS scavenger (N-acetyl-L-cysteine). In the in vivo mouse xenograft model, DVDMS-SDT showed efficient anti-cancer effects with no visible side effects. Conclusion: DVDMS-SDT induced apoptosis in H446 cells, in part by targeting mitochondria through the mitochondria-mediated apoptosis signaling pathway, and the extrinsic apoptosis pathway was also shown to be involved. Both apoptosis and changes in RIP3 expression were closely related to the generation of ROS. DVDMS-SDT will be advantageous for the management of small cell lung cancer due to its noninvasive characteristics.

show abstract

“…It uses a combination of low-intensity ultrasound and specialised chemical agents termed sonosensitizers, which are drugs that can be activated by ultrasound. Ultrasound is able to penetrate deeply into tissues and can be focused on a small region of tumor where it activates the sonosensitizer, creating a cascade of endogenous cytotoxic agents [4]. The advantage of ultrasound is that it penetrates more deeply than light, and therefore it is likely to be more effective for the treatment of deeper tumours than PDT [4].…”

mentioning

confidence: 99%

“…SDT is understood to produce cavitation around the surface of cancer cells, with the energy released following the collapse of the cavitating bubbles creating sonoluminescent light in the cancer cells [4]. The sonosensitizer is activated to an excited state from its ground state, and upon return to its ground state, released energy is transferred to the circumambient oxygen.…”

mentioning

confidence: 99%

“…The sonosensitizer is activated to an excited state from its ground state, and upon return to its ground state, released energy is transferred to the circumambient oxygen. This produces a large amount of reactive oxygen species (ROS) which mediate mitochondrial-dependent cell apoptosis by damaging the mitochondrial membrane and causing the release of Cytochrome C [4]. For a comprehensive explanation of the potential mechanisms by which SDT works see Wan et al [4].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Sonodynamic and Photodynamic Therapy in Breast Cancer - A Pilot Study

Zhang¹

2017

IJCAM

View full text Add to dashboard Cite

In this exploratory pilot study, we investigated the potential efficacy of a new systemic tumor therapeutic method as a supplementary or salvage treatment in advanced refractory breast cancer. Termed Sono-Photo Dynamic Therapy (SPDT), this technology utilizes full body and targeted ultrasound in conjunction with photodynamic therapy. Twelve patients with advanced breast carcinoma participated, eleven with metastases in the viscera and brain, and nine within bone. Nine patients had concurrent low dose chemotherapy with the SPDT. After the first round of treatment (where the number of cycles of SPDT varied from 1-4), the overall response rate was 75% (two patients achieved Complete Response [16.67%] and seven patients achieved Partial Response [58.33%]). Results suggest that SPDT was not associated with serious side effects, and may enhance chemotherapy efficacy in the treatment of advanced refractory breast cancer. Despite the exploratory nature of this study, the results suggest that SPDT shows promise as a new systemic approach for tumor adjunct therapy and merits further investigation.

show abstract

Recent advances of sonodynamic therapy in cancer treatment

Cited by 235 publications

References 83 publications

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Sinoporphyrin Sodium-Mediated Sonodynamic Therapy Inhibits RIP3 Expression and Induces Apoptosis in the H446 Small Cell Lung Cancer Cell Line

Sonodynamic and Photodynamic Therapy in Breast Cancer - A Pilot Study

Contact Info

Product

Resources

About