Recent Advances of Zinc‐based Antimicrobial Materials

Riduan, Siti Nurhanna; Zhang, Yugen

doi:10.1002/asia.202100656

Cited by 74 publications

(25 citation statements)

References 41 publications

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“…It is commonly accepted that the pH of the infectious wound microenvironment was weakly acidic. , Bacterial pathogens could produce destructive enzymes and toxins, lowering the local pH in the wound microenvironment. The bactericidal activity of ZEM could accredit to the sudden release of zinc ions. , As a result of the release pattern of ZEM shown in Figure k, Zn 2+ released from ZEM increased as the pH of the buffer solution decreased from 7.4 to 6.0. This suggested that the ZEM nanoplatform was capable of detecting the weakly acidic microenvironment of the infectious wound and the low-pH environment initiated a faster release of Zn 2+ from ZEM.…”

Section: Resultsmentioning

confidence: 97%

Logic-Based Diagnostic and Therapeutic Nanoplatform with Infection and Inflammation Monitoring and Microenvironmental Regulation Accelerating Wound Repair

Liu

Wang

et al. 2022

ACS Appl. Mater. Interfaces

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Infectious cutaneous wounds are a thorny clinical problem. The microenvironment of the infectious wound is complicated and changes at different healing stages. Traditional treatments either have a single effect such as anti-inflammation, antibacteria, or angiogenesis or a simple mixture of several functions. They fail to deal with the change of the physiological healing process, leading to unsatisfactory outcomes. Herein, we have designed a logic-based smart nanoplatform (named as ZEM), aiming to self-monitor the wound microenvironment and accordingly react to the changes of the healing process, fitting multiple needs of physiological repair at different stages. ZEM was synthesized using zeolitic imidazolate framework-8 (ZIF-8) coated with an epigallocatechin gallate (EGCG)/Mg2+ complex. We characterized ZEM in the aspects of morphology, physical and chemical properties, and ion release pattern. At the initial stage, ZEM sensed the weakly acidic environment and responsively released a large number of zinc ions to eliminate bacterial infection. Then came the second inflammation stage, where ZEM responded to the oxidative stress of the local wound area with EGCG absorbing excessive reactive oxygen species (ROS), contributing to the downregulation of intracellular ROS. Meanwhile, local inflammation was alleviated by reducing the expression of proinflammatory M1 phenotype factors (IL-6, TNF-α, and IL-1β). Since the balance of local ROS had been achieved, the resulting disintegration of the EGCG/Mg2+ complex gave rise to the sustainable release of Mg2+ at the proliferation stage, promoting vascularized healing. In vivo animal experiments further proved the diagnostic and therapeutic functions of ZEM. All these results demonstrated that ZEM was a promising treatment strategy in soft tissue engineering.

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Section: Resultsmentioning

confidence: 97%

Logic-Based Diagnostic and Therapeutic Nanoplatform with Infection and Inflammation Monitoring and Microenvironmental Regulation Accelerating Wound Repair

Liu

Wang

et al. 2022

ACS Appl. Mater. Interfaces

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“…Prior work demonstrated the bacteriocidal effect of phanorods in vitro. Conjugation of Pol-K and Zn 2+ -loading of phanorods (i.e., phanorod-Zn) was expected to increase the antibacterial effect due to the known antimicrobial effects of Zn 2+ . , We first tested the bacteriocidal activity of phanorod-Zn in a suspension of P. aeruginosa cells. Irradiation of phanorods and phanorod-Zn (10 14 particles/mL) by 808 nm near-infrared (NIR) light (0.3 W cm –2 ) for 15 min resulted in an equilibrium bulk temperature of ∼55 °C (Figure S1).…”

Section: Resultsmentioning

confidence: 99%

Treatment of Wound Infections in a Mouse Model Using Zn²⁺-Releasing Phage Bound to Gold Nanorods

et al. 2022

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Infections caused by drug-resistant bacteria, particularly Gram-negative organisms, are increasingly difficult to treat using antibiotics. A potential alternative is “phage therapy”, in which phages infect and lyse the bacterial host. However, phage therapy poses serious drawbacks and safety concerns, such as the risk of genetic transduction of antibiotic resistance genes, inconsistent pharmacokinetics, and unknown evolutionary potential. In contrast, metallic nanoparticles possess precise, tunable properties, including efficient conversion of electronic excitation into heat. In this work, we demonstrate that engineered phage-nanomaterial conjugates that target the Gram-negative pathogen Pseudomonas aeruginosa are highly effective as a treatment of infected wounds in mice. Photothermal heating, performed as a single treatment (15 min) or as two treatments on consecutive days, rapidly reduced the bacterial load and released Zn 2+ to promote wound healing. The phage-nanomaterial treatment was significantly more effective than systemic standard-of-care antibiotics, with a >10× greater reduction in bacterial load and ∼3× faster healing as measured by wound size reduction when compared to fluoroquinolone treatment. Notably, the phage-nanomaterial was also effective against a P. aeruginosa strain resistant to polymyxins, a last-line antibiotic therapy. Unlike these antibiotics, the phage-nanomaterial showed no detectable toxicity or systemic effects in mice, consistent with the short duration and localized nature of phage-nanomaterial treatment. Our results demonstrate that phage therapy controlled by inorganic nanomaterials can be a safe and effective antimicrobial strategy in vivo.

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“…Therefore, a promising direction is the development of biocidal composite binders, which make it possible to provide long-term volumetric protection of the material from biocorrosion. In accordance with the data [ 13 , 14 ], the use of substances containing copper and zinc makes it possible to ensure the biocidal properties of cement composites, which helps to solve the problem of material destruction due to biocorrosion [ 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. Thus, hydrosilicates of zinc and copper can be a promising additive for the creation of composite binders, since they allow reducing the consumption of cement in the binder and ensuring the biostability of the resulting cement composites.…”

Section: Introductionmentioning

confidence: 80%

Hydration of Cement in the Presence of Biocidal Modifiers Based on Metal Hydrosilicates

2021

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This article presents the results of a study of the characteristics of hydration and properties of a composite biocidal cement binder containing hydrosilicates of barium, copper or zinc. It was found that copper hydrosilicates block hydration processes, and when zinc hydrosilicates are used, the rate of hydration is determined by the content of silicic acid. The limiting concentrations of biocidal modifiers have been established: zinc hydrosilicates—no more than 4% and copper hydrosilicates—no more than 0.5%, which are advisable to use for the manufacture of a biocidal composite binder. It is shown that modifying additives slow down the setting time, the amount of tricalcium silicate in cement stones increases, and their strength for some compositions decreases. Active binding of portlandite with the formation of calcium hydrosilicates occurs when the content of zinc hydrosilicates is 2%, which leads to an increase in the strength of the materials.

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Recent Advances of Zinc‐based Antimicrobial Materials

Cited by 74 publications

References 41 publications

Logic-Based Diagnostic and Therapeutic Nanoplatform with Infection and Inflammation Monitoring and Microenvironmental Regulation Accelerating Wound Repair

Logic-Based Diagnostic and Therapeutic Nanoplatform with Infection and Inflammation Monitoring and Microenvironmental Regulation Accelerating Wound Repair

Treatment of Wound Infections in a Mouse Model Using Zn²⁺-Releasing Phage Bound to Gold Nanorods

Hydration of Cement in the Presence of Biocidal Modifiers Based on Metal Hydrosilicates

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Recent Advances of Zinc‐based Antimicrobial Materials

Cited by 74 publications

References 41 publications

Logic-Based Diagnostic and Therapeutic Nanoplatform with Infection and Inflammation Monitoring and Microenvironmental Regulation Accelerating Wound Repair

Logic-Based Diagnostic and Therapeutic Nanoplatform with Infection and Inflammation Monitoring and Microenvironmental Regulation Accelerating Wound Repair

Treatment of Wound Infections in a Mouse Model Using Zn2+-Releasing Phage Bound to Gold Nanorods

Hydration of Cement in the Presence of Biocidal Modifiers Based on Metal Hydrosilicates

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Treatment of Wound Infections in a Mouse Model Using Zn²⁺-Releasing Phage Bound to Gold Nanorods