Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review)

Sadeghzade, Sorour; Liu, Jingyi; Wang, Huiru; Li, Xin; Cao, Jinrui; BinTang,; Yuan, Huatang

doi:10.1016/j.mtbio.2022.100473

Cited by 42 publications

(20 citation statements)

References 148 publications

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“…2023, 33, 2214726 Reproduced with permission. [230] Copyright 2022, Elsevier Inc. B) The interaction mechanism of bioactive ions stimulating human umbilical vein endothelial cells (HUVECs) and human BMSCs. Reproduced with permission.…”

Section: Bone Defect Repairmentioning

confidence: 99%

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Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

118

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It is an urgent need that defect repair can develop from simple device fixation to living tissue reconstruction, from short life function replacement to permanent regeneration repair. At present, bone transplantation has become the second largest transplantation surgery after blood transfusion, and artificial bone transplantation generates great hope for the repair and treatment of bone defect. In order to repair bone defect, artificial bone must have good biological properties and sufficient mechanical properties, and it should also have the shape matching to bone defect site and the connected porous structure. For structures and properties requirements of artificial bone, in this review three major challenges faced by artificial bone transplantation are systemtically analyzed and current methods and strategies to address these issues are discussed: 1) the need for developing a type of bone scaffold material with both biological and mechanical properties, 2) the need for realizing the controllable fabrication of individual shape and multistage pore structure of bone scaffold, 3) the need for realizing the transformation from man‐made structure to biological structure. Besides, it summarizes the advantages and disadvantages of these methods and discusses the potential future directions of structural and functional adaptive artificial bone for bone defect regeneration.

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Section: Bone Defect Repairmentioning

confidence: 99%

“…Calcium-silicon-based ceramics and their effect on cells and bone regeneration. A) Several representative calcium-silicon-based ceramics.Reproduced with permission [230]. Copyright 2022, Elsevier Inc. B) The interaction mechanism of bioactive ions stimulating human umbilical vein endothelial cells (HUVECs) and human BMSCs.…”

mentioning

confidence: 99%

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

118

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“…As described in [ 105 ], the ceramic materials eligible for bone-tissue replacement can be divided into three main sets: structural ceramics, calcium phospates, and bioactive glasses. The first group includes alumina (Al 2 O 3 ) and zirconia (ZrO 2 ), which exhibit high hardness and high wear resistance, and this can be considered a problem if the stress-shielding effect is eventually induced in the implant [ 106 ]. This phenomenon occurs when a stiff scaffold material does not match the mechanical properties of the tissue to regenerate and, conversely, carries most of the imposed load, thus inhibiting, according to Wolff’s law, the natural growth and self-stiffening of bone tissue in the implantation site.…”

Section: Ceramic Materials For Biomedical Applicationsmentioning

confidence: 99%

Ceramic Materials for Biomedical Applications: An Overview on Properties and Fabrication Processes

Vaiani

Boccaccio

Uva

et al. 2023

JFB

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A growing interest in creating advanced biomaterials with specific physical and chemical properties is currently being observed. These high-standard materials must be capable to integrate into biological environments such as the oral cavity or other anatomical regions in the human body. Given these requirements, ceramic biomaterials offer a feasible solution in terms of mechanical strength, biological functionality, and biocompatibility. In this review, the fundamental physical, chemical, and mechanical properties of the main ceramic biomaterials and ceramic nanocomposites are drawn, along with some primary related applications in biomedical fields, such as orthopedics, dentistry, and regenerative medicine. Furthermore, an in-depth focus on bone-tissue engineering and biomimetic ceramic scaffold design and fabrication is presented.

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“…Recently, with the development of 3D printers and additive manufacturing, 3D porous materials with arbitrary pore structures have been reproducibly and directly produced. − Stereolithography apparatus (SLA) and digital light processing (DLP) 3D printing can accurately fabricate complex pore structures. − For example, strut-based lattice structures (e.g., grids) and triply periodic minimal surface (TPMS)-based lattice structures (e.g., gyroids) have been fabricated. − Previous studies fabricated materials with the same pore structure and different compositions by SLA printing and investigated the effect of composition on bone formation by comparing these materials. − However, the effects of composition showed the same trend whether they were fabricated by conventional methods or by 3D printing.…”

Section: Introductionmentioning

confidence: 99%

Superiority of Triply Periodic Minimal Surface Gyroid Structure to Strut-Based Grid Structure in Both Strength and Bone Regeneration

Hayashi

Kishida

Tsuchiya

et al. 2023

ACS Appl. Mater. Interfaces

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The aging population has rapidly driven the demand for bone regeneration. The pore structure of a scaffold is a critical factor that affects its mechanical strength and bone regeneration. Triply periodic minimal surface gyroid structures similar to the trabecular bone structure are considered superior to strut-based lattice structures (e.g., grids) in terms of bone regeneration. However, at this stage, this is only a hypothesis and is not supported by evidence. In this study, we experimentally validated this hypothesis by comparing gyroid and grid scaffolds composed of carbonate apatite. The gyroid scaffolds possessed compressive strength approximately 1.6-fold higher than that of the grid scaffolds because the gyroid structure prevented stress concentration, whereas the grid structure could not. The porosity of gyroid scaffolds was higher than that of the grid scaffolds; however, porosity and compressive strength generally have a trade-off relationship. Moreover, the gyroid scaffolds formed more than twice the amount of bone as grid scaffolds in a critical-sized bone defect in rabbit femur condyles. This favorable bone regeneration using gyroid scaffolds was attributed to the high permeability (i.e., larger volume of macropores or porosity) and curvature profile of the gyroid structure. Thus, this study validated the conventional hypothesis using in vivo experiments and revealed factors that led to this hypothetical outcome. The findings of this study are expected to contribute to the development of scaffolds that can achieve early bone regeneration without sacrificing the mechanical strength.

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Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review)

Cited by 42 publications

References 148 publications

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Ceramic Materials for Biomedical Applications: An Overview on Properties and Fabrication Processes

Superiority of Triply Periodic Minimal Surface Gyroid Structure to Strut-Based Grid Structure in Both Strength and Bone Regeneration

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