Recent  advances on smart TiO&lt;sub&gt;2&lt;/sub&gt;&amp;nbsp;nanotube platforms for sustainable drug delivery applications

Wang, Qun; Huang, Jianying; Li, Huaqiong; Zhao, Allan Z.; Wang, Yi; Zhang, Ke‐Qin; Sun, Hongtao; Lai, Yuekun

doi:10.2147/ijn.s117498

Cited by 107 publications

(66 citation statements)

References 98 publications

(116 reference statements)

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“…Another characteristic of this nano-modified surface is a drug delivery effect [55][56][57][58]. Drug release from TiO 2 nanotubes is associated with the dimensions of TiO 2 nanotube arrays regardless of the direct release or indirect discharge by nanocarriers [59].…”

Section: Functional Peptidesmentioning

confidence: 99%

“…The diameter and length of TiO 2 nanotubes generally increase as the voltage and duration of the oxidation process increase, and the drug release has been found to be effective when the diameter is larger than approximately 100 nm [56,59,60]. A combination of this nano-modified TiO 2 surface and carrier molecules, including micelles, is being actively investigated for drug delivery at a constant rate, unrelated to the drug concentration and release period [57,58,60].…”

Section: Functional Peptidesmentioning

confidence: 99%

“…Recently, the hexagonal nano-structure of the base Ti surface was evaluated to be adequate for biologic application when the TiO 2 nanotube arrays are removed from the base surface in order to prevent the delamination of the TiO 2 nanotube coating in an in vivo environment (Figure 2) [44]. The aligned TiO 2 nanotube-layered surface has great potential in biologic and clinical applications [55][56][57]65]. However, it is necessary to overcome this delamination problem before this TiO 2 nanotubular surface is clinically used in the field of dental implantology.…”

Section: Functional Peptidesmentioning

confidence: 99%

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Modifications of Dental Implant Surfaces at the Micro- and Nano-Level for Enhanced Osseointegration

2019

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This review paper describes several recent modification methods for biocompatible titanium dental implant surfaces. The micro-roughened surfaces reviewed in the literature are sandblasted, large-grit, acid-etched, and anodically oxidized. These globally-used surfaces have been clinically investigated, showing survival rates higher than 95%. In the past, dental clinicians believed that eukaryotic cells for osteogenesis did not recognize the changes of the nanostructures of dental implant surfaces. However, research findings have recently shown that osteogenic cells respond to chemical and morphological changes at a nanoscale on the surfaces, including titanium dioxide nanotube arrangements, functional peptide coatings, fluoride treatments, calcium–phosphorus applications, and ultraviolet photofunctionalization. Some of the nano-level modifications have not yet been clinically evaluated. However, these modified dental implant surfaces at the nanoscale have shown excellent in vitro and in vivo results, and thus promising potential future clinical use.

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Section: Functional Peptidesmentioning

confidence: 99%

Section: Functional Peptidesmentioning

confidence: 99%

Section: Functional Peptidesmentioning

confidence: 99%

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Modifications of Dental Implant Surfaces at the Micro- and Nano-Level for Enhanced Osseointegration

2019

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“…The inner volume of TiO 2 nanotubes can be also filled with chemicals and biomolecules, such as enzymes or proteins. Subsequently, TNA could be applied into new drug-releasing implants for emerging therapies for localized drug delivery [53,54]. Whereby, the TNA topology can be coated with inflammation-reducing drugs, such as dexamethasone, by using simple physical adsorption or deposition of the drug by magnetic stimuli-responsive drug delivery system as described in Figure 2.…”

Section: Nanomatrix Therapeutic Inductionmentioning

confidence: 99%

Titanium Dioxide Nanotube Arrays for Biomedical Implant Materials and Nanomedicine Applications

Mydin¹,

Hazan²,

FadzilFaridWajidi³

et al. 2018

Titanium Dioxide - Material for a Sustainable Environment

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Nanotechnology has become a research hotspot to explore functional nanodevices and design materials compatible with nanoscale topography. Recently, titanium dioxide nanotube arrays (TNA) have garnered considerable interest as biomedical implant materials and nanomedicine applications (such as nanotherapeutics, nanodiagnostics and nanobiosensors). In bio-implants studies, the properties of TNA nanostructures could modulate diverse cellular processes, such as cell adhesion, migration, proliferation, and differentiation. Furthermore, this unique structure of TNA provides larger surface area and energy to regulate positive cellular interactions toward the mechanosensitivity activities. As for an advanced medical application, the TNA-biomolecular interactions knowledge are critical for further characterization of nanomaterial particularly in nanotherapeutic manipulation. Knowledge of these aspects will create opportunities for better understanding which may help researchers to develop better nanomaterial products to be used in medicine and health-line services.

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“…In particular, the presence of oriented factors in environment lead to occurrence of directed movement patterns, different from pure diffusion (Armsworth and Bode 1999, Belgacem and Cosner 1995, Cantrell et al 2006. In this concern, it is worthwhile to mention also the modern technologies of controlled drug delivery, using an external oriented magnetic field (Zakharchenko et al 2018), and the implants based on arrays of oriented TiO 2 nanotubes, which control the directed release of drugs (Losic et al 2015, Wang et al 2017.…”

mentioning

confidence: 99%

On the shape of invading population in anisotropic environments

Blavatska

2020

Math. Model. Nat. Phenom.

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We analyze the properties of population spreading in environments with spatial anisotropy within the frames of a lattice model of asymmetric (biased) random walkers. The expressions for the universal shape characteristics of the instantaneous configuration of population, such as asphericity A and prolateness S are found analytically and proved to be dependent only on the asymmetric transition probabilities in different directions. The model under consideration is shown to capture, in particular, the peculiarities of invasion in presence of an array of oriented tubes (fibers) in the environment.

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Recent advances on smart TiO<sub>2</sub> nanotube platforms for sustainable drug delivery applications

Cited by 107 publications

References 98 publications

Modifications of Dental Implant Surfaces at the Micro- and Nano-Level for Enhanced Osseointegration

Modifications of Dental Implant Surfaces at the Micro- and Nano-Level for Enhanced Osseointegration

Titanium Dioxide Nanotube Arrays for Biomedical Implant Materials and Nanomedicine Applications

On the shape of invading population in anisotropic environments

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