Recent application developments of water-soluble synthetic polymers

Halake, Kantappa; Birajdar, Mallinath S.; Kim, Byoung Soo; Bae, Harim; Lee, CheongCheon; Kim, Yoo Jin; Kim, Sinwoo; Kim, Hyun Jin; Ahn, Soohwan; An, Su; Lee, Jonghwi

doi:10.1016/j.jiec.2014.01.006

Cited by 95 publications

(44 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…During the last few years, the use of monomers with a polyethylene glycol (PEG) side chain in the synthesis of polymeric materials (as comonomers in aqueous-phase solution copolymerization [1][2][3] or as reactive stabilizers in several heterogeneous polymerization systems) [4][5][6][7] has gained increasing attention. Water-soluble polymers are used in a variety of applications including coatings, cosmetics, antiflocculants, textiles, superabsorbers and water treatment [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Kinetics of the Aqueous-Phase Copolymerization of MAA and PEGMA Macromonomer: Influence of Monomer Concentration and Side Chain Length of PEGMA

et al. 2017

View full text Add to dashboard Cite

An in situ nuclear magnetic resonance spectroscopy (NMR) technique is used to monitor the aqueous-phase copolymerization kinetics of methacrylic acid (MAA) and poly(ethylene glycol) methyl ether methacrylate (PEGMA) macromonomers. In particular, the study analyses the effect of the number of ethylene glycol (EG) groups along the lateral chains of PEGMA and is carried out under fully ionized conditions of MAA at different initial monomer ratios and initial overall monomer concentrations (5-20 wt % in aqueous solution). The composition drift with conversion indicates that PEGMA macromonomer is more reactive than MAA. Individual monomer consumption rates show that the rates of consumption of both monomers are not first order with respect to overall concentration of the monomer. The reactivity ratios estimated from the copolymerization kinetics reveal, that for the short PEGMA, the reactivity ratios r MAA and r PEGMA increase with the solids content (SC). A totally different trend is obtained for the longer PEGMA, whose reactivity ratio (r PEGMA23 ) decreases with solids content, whereas the reactivity ratio of MAA remains roughly constant.

show abstract

Section: Introductionmentioning

confidence: 99%

Kinetics of the Aqueous-Phase Copolymerization of MAA and PEGMA Macromonomer: Influence of Monomer Concentration and Side Chain Length of PEGMA

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Moreover, they usually show better performance in solubility, thus simplifying their processing and application [7]. In addition, synthetic polymers are nowadays thoroughly examined regarding their mechanical and thermal behavior or the kinetics of polymerization, providing the necessary knowledge to synthesize tailormade polymers for individual applications [8]. For example, polycaprolactone, often used in tissue engineering, is known for its excellent biocompatibility, but also for its poor thermal and mechanical properties [9].…”

Section: Introductionmentioning

confidence: 99%

Potentially biocompatible polyacrylamides derived by the Ugi four-component reaction

Sehlinger

Ochsenreither

Bartnick

et al. 2015

European Polymer Journal

View full text Add to dashboard Cite

“…In a previous study, the IDR for ASSF was 8.8±0.6 mg/cm 2 /min ( Figure 1B) (Nielsen et al, 2013a), and significant difference was therefore found (pvalue 0.0236). It can therefore be concluded that PVP did affect the dissolution rate of ASSF in a positive fashion due to the hydrophilic nature of PVP (Halake et al, 2014). A fast dissolution rate is important for developing a good drug formulation of furosemide, and glass solutions will often provide this because of the hydrophilic properties of the polymer.…”

Section: Biorelevant Dissolution Of Assf In the Glass Solutionmentioning

confidence: 98%

Stabilisation of amorphous furosemide increases the oral drug bioavailability in rats

Nielsen

Rades

2015

International Journal of Pharmaceutics

View full text Add to dashboard Cite

A glass solution of the amorphous sodium salt of furosemide (ASSF) and polyvinylpyrrolidone (PVP) (80:20 w/w%) was prepared by spray drying. It was investigated if PVP was able to stabilise ASSF during storage and dissolution and whether this influenced the in vivo performance of the glass solution after oral dosing to rats. The glass solution had a glass transition temperature of 121.3±0.5°C, which was significantly higher than that of the pure drug (101.2°C). ASSF in the glass solution was stable for at least 168 days when stored at 20°C and 0% relative humidity. The glass solution exhibited fast dissolution in simulated intestinal medium, pH 6.5; the intrinsic dissolution rate was found to be 10.1±0.6 mg/cm 2 /min, which was significantly faster than the pure ASSF. When investigating the stability during dissolution in stimulated intestinal medium at pH 6.5, the ASSF in the glass solution showed signs of crystallinity after 1 min of dissolution, but crystallised to a lesser extent than pure ASSF. The stabilising effect of PVP on ASSF, led to improved relative oral bioavailability in rats of 263%, when compared to the pure ASSF.

show abstract

Recent application developments of water-soluble synthetic polymers

Cited by 95 publications

References 111 publications

Kinetics of the Aqueous-Phase Copolymerization of MAA and PEGMA Macromonomer: Influence of Monomer Concentration and Side Chain Length of PEGMA

Kinetics of the Aqueous-Phase Copolymerization of MAA and PEGMA Macromonomer: Influence of Monomer Concentration and Side Chain Length of PEGMA

Potentially biocompatible polyacrylamides derived by the Ugi four-component reaction

Stabilisation of amorphous furosemide increases the oral drug bioavailability in rats

Contact Info

Product

Resources

About