Recent Applications of Chiral Ferrocene Ligands in Asymmetric Catalysis

Abstract

Despite the impressive progress achieved in asymmetric catalysis during the last decade, an increasing number of new catalysts, ligands, and applications are reported every year to satisfy the need to embrace a wider range of reactions and to improve the efficiency of existing processes. Because of their availability, unique stereochemical aspects, and wide variety of coordination modes and possibilities for the fine-tuning of the steric and electronic properties, ferrocene-based ligands constitute one of the most versatile ligand architectures in the current scenario of asymmetric catalysis. Over the last few years ferrocene catalysts have been successfully applied in an amazing variety of enantioselective processes. This Review documents these recent advances, with special emphasis on the most innovative asymmetric processes and the development of novel, efficient types of ferrocene ligands.

Ferrocene-derived P,N ligands: synthesis and application in enantioselective catalysis

“…Numerous reviews have highlighted the synthesis and applications of ferrocene-based ligands in the past [12][13][14][15][16][17]. With this review, we wish to give a focused and up-to-date summary of the synthetic routes towards chiral hybrid P,N-ferrocenyl ligands and an overview of the applications of these ligands in enantioselective catalysis.…”

Advances in Enantioselective C–H Activation/Mizoroki-Heck Reaction and Suzuki Reaction

“…It is well known that planar chiral ferrocenes are frequently applied as highly efficient catalysts or ligands in asymmetric synthesis [66][67][68][69][70][71]. Inspired by previous studies from Yu group [44,62], You et al, developed an enantioselective syntheses of planar chiral ferrocenes via palladium-catalyzed direct coupling with arylboronic acids in 2013 (Scheme 15) [72].…”

Preparation of chiral oxazolinyl-functionalized β-cyclodextrin-bonded stationary phases and their enantioseparation performance in high-performance liquid chromatography

“…Ferrocene derivatives have attracted growing interest due to their significant role as catalysts in asymmetric reactions [22]. Three ferrocene derivatives were examined in this paper (Table 1, entries [14][15][16].…”