Recent Applications of Electrospun Nanofibrous Scaffold in Tissue Engineering

Abstract

Tissue engineering is a relatively new area of research that combines medical, biological, and engineering fundamentals to create tissue-engineered constructs that regenerate, preserve, or slightly increase the functions of tissues. To create mature tissue, the extracellular matrix should be imitated by engineered structures, allow for oxygen and nutrient transmission, and release toxins during tissue repair. Numerous recent studies have been devoted to developing three-dimensional nanostructures for tissue engineering. One of the most effective of these methods is electrospinning. Numerous nanofibrous scaffolds have been constructed over the last few decades for tissue repair and restoration. The current review gives an overview of attempts to construct nanofibrous meshes as tissue-engineered scaffolds for various tissues such as bone, cartilage, cardiovascular, and skin tissues. Also, the current article addresses the recent improvements and difficulties in tissue regeneration using electrospinning.

Co-axial fibrous scaffolds integrating with carbon fiber promote cardiac tissue regeneration post myocardial infarction

“…For uses in cardiac tissue engineering, scaffolds need sufficient stiffness and conductivity as well as fibrous structures that provide environment mimicking the heart muscle. Although electrospinning technique has been widely applied to generate fibrous scaffolds in the cardiac tissue regeneration [ 20 , 46 ], it was usually applied to produce fibrous membranes instead of three-dimensional scaffolds. In addition, the stiffness of fibrous membranes alone usually is too low to meet the requirement of cardiac tissue contraction.…”

Bioengineering lungs: An overview of current methods, requirements, and challenges for constructing scaffolds

“…Particularly in terms of lungs, electrospinning and 3D bioprinting have been gaining more attention recently. Electrospinning has emerged as a promising method and is considered to be effective in producing porous structures composed of thin, nano-fibers, that are capable of providing enough support for the cell attachments, proliferation, and differentiation ( Persano et al, 2013 ; Owida et al, 2022 ). However, challenges such as geometry control, cell damage, and insufficient control of cell patterning remain an issue ( Jun et al, 2018 ).…”

Nano artificial periosteum PLGA/MgO/Quercetin accelerates repair of bone defects through promoting osteogenic − angiogenic coupling effect via Wnt/ β-catenin pathway

“…Nanofiber membranes prepared by electrospinning are a promising artificial periosteum, owing to their similarity to the extracellular matrix and periosteum structure; this helps to induce osteoblast adhesion, proliferation, differentiation, mineralization, and neovascularization [ [7] , [8] , [9] , [10] ]. Biomaterials prepared by electrospinning have been proved to promote critical-size bone defect repair [ 11 ].…”