Recent Applications of the Suzuki-Miyaura Cross-coupling to Complex Polycyclic Ether Synthesis

More than thirty years after the discovery of polycyclic ether marine natural products, they continue to receive intense attention from the chemical, biological, and pharmacological communities because of their potent biological activities and highly complex molecular architectures. Gambieric acids are intriguing polycyclic ethers that exhibit potent antifungal activity with minimal toxicity against mammals. Despite the recent advances in the synthesis of this class of natural products, gambieric acids remain unconquered due to their daunting structural complexity, which poses a formidable synthetic challenge to organic chemists. This paper reviews our long-term studies on the total synthesis, complete configurational reassignment, and structure-activity relationships of gambieric acid A over the last decade.

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The Literature of Heterocyclic Chemistry, Part XII, 2010–2011

Беленький

Evdokimenkova

2014

Advances in Heterocyclic Chemistry

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Recent Applications of the Suzuki-Miyaura Cross-coupling to Complex Polycyclic Ether Synthesis

Cited by 3 publications

References 109 publications

ChemInform Abstract: Recent Applications of the Suzuki—Miyaura Cross—Coupling to Complex Polycyclic Ether Synthesis

ChemInform Abstract: Recent Applications of the Suzuki—Miyaura Cross—Coupling to Complex Polycyclic Ether Synthesis

Total Synthesis and Complete Structural Assignment of Gambieric Acid A, a Large Polycyclic Ether Marine Natural Product

The Literature of Heterocyclic Chemistry, Part XII, 2010–2011

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