Recent approaches for the treatment of periodontitis

Jain, Neeraj; Jain, Gaurav; Javed, Shamama; Iqbal, Zeenat; Talegaonkar, Sushama; Ahmad, Feroz; Khar, Roop K.

doi:10.1016/j.drudis.2008.07.010

Cited by 199 publications

(172 citation statements)

References 77 publications

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“…Jain et al studied the advances in understanding the aetiology, epidemiology and microbiology of periodontal pocket flora in revolutionising the therapeutic strategies for the management of periodontal disease progression and summarised the recent developments in the field of intrapocket drug delivery systems and identifies areas where further research may lead to a clinically effective intrapocket delivery system [139] .…”

Section: Recent Advances Of Bioenhancersmentioning

confidence: 99%

Bioavailability enhancers of herbal origin: An overview

Kesarwani

Gupta

2013

Asian Pacific Journal of Tropical Biomedicine

397

197

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Section: Recent Advances Of Bioenhancersmentioning

confidence: 99%

Bioavailability enhancers of herbal origin: An overview

Kesarwani

Gupta

2013

Asian Pacific Journal of Tropical Biomedicine

397

197

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“…15,16 The complexity of access to periodontal tissues makes all of these systems only partially successful. 17 There are a few studies about preparation of antibacterial nanoparticles for periodontal therapy. 18,19 Nanoparticles provide several advantages.…”

Section: Introductionmentioning

confidence: 99%

“…For example, because of their small size, they penetrate areas (extracellular and intracellular areas) that may be inaccessible to other delivery systems, such as bacterial cells, alveolar bone trabeculae, and from the gingival sulcus inward to the underlying connective tissue and to the periodontal pocket areas below the gum line. 17,19,20 Nanoparticles protect a drug against in vivo degradation and reduce side effects. They also have more favorable drug pharmacokinetics.…”

Section: Introductionmentioning

confidence: 99%

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Dinarvand¹,

Kashi²,

Eskandarion³

et al. 2012

IJN

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Background: Low drug entrapment efficiency of hydrophilic drugs into poly(lactic-co-glycolic acid) (PLGA) nanoparticles is a major drawback. The objective of this work was to investigate different methods of producing PLGA nanoparticles containing minocycline, a drug suitable for periodontal infections. Methods: Different methods, such as single and double solvent evaporation emulsion, ion pairing, and nanoprecipitation were used to prepare both PLGA and PEGylated PLGA nanoparticles. The resulting nanoparticles were analyzed for their morphology, particle size and size distribution, drug loading and entrapment efficiency, thermal properties, and antibacterial activity. Results: The nanoparticles prepared in this study were spherical, with an average particle size of 85-424 nm. The entrapment efficiency of the nanoparticles prepared using different methods was as follows: solid/oil/water ion pairing (29.9%) . oil/oil (5.5%) . water/oil/water (4.7%) . modified oil/water (4.1%) . nano precipitation (0.8%). Addition of dextran sulfate as an ion pairing agent, acting as an ionic spacer between PEGylated PLGA and minocycline, decreased the water solubility of minocycline, hence increasing the drug entrapment efficiency. Entrapment efficiency was also increased when low molecular weight PLGA and high molecular weight dextran sulfate was used. Drug release studies performed in phosphate buffer at pH 7.4 indicated slow release of minocycline from 3 days to several weeks. On antibacterial analysis, the minimum inhibitory concentration and minimum bactericidal concentration of nanoparticles was at least two times lower than that of the free drug. Conclusion: Novel minocycline-PEGylated PLGA nanoparticles prepared by the ion pairing method had the best drug loading and entrapment efficiency compared with other prepared nanoparticles. They also showed higher in vitro antibacterial activity than the free drug.

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“…Nanotechnology is a discipline that has expanded rapidly into all areas of science and it offers valuable options for solving medical and scientific problems and questions (Abou Neel et al, 2015). A dental field of nanotechnology called nanodentistry is very promising and have demonstrated various treatment opportunities in dentistry in areas such as dental re-naturalization, local anesthesia, teeth hypersensitivity cure (Sahoo et al, 2007), periodontal regeneration (Walmsley et al, 2015), controlled drug delivery (Abou Neel et al, 2015;Jain et al, 2008) and overall oral health maintenance (Ozak and Ozkan, 2013), among others. This highly promising field may ensure the attainment of near perfect oral health by way of using nanomaterials, nanorobotics, biotechnology, etc.…”

Section: Introductionmentioning

confidence: 99%

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Aminu¹,

Chan²,

Toh³

2017

J App Pharm Sci

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Formulation scientists are faced with a great hurdle of delivering a therapeutic agent into the periodontal pockets because of the anatomical complexity of the route and the lesion's contours that often leads to poor penetration of the drug to the area. However, recent nanotechnology advancement and innovations through nanodentistry are increasingly providing a suitable solution for the treatment of many dental disorders including periodontal disease. These nanodentistry innovative approaches have vowed to revolutionize dental therapeutics by way of using nanomaterials, biotechnology, and nanorobotics, that can significantly influence and transform dental disease's diagnosis, prevention, and treatment. The advances have offered possibilities for providing highquality dental care to a vast number of people around the globe who are currently suffering from periodontal disease. Novel nanotechnology-based carriers and materials such as polymeric nanoparticles, nanogels, nanopores, nanotubes, scaffold matrices, nanoneedles, nanocrystals, quantum dots, nanofibers, and nanofillers have demonstrated promising efficacy and their roles in the disease therapy are of great significance. The aim of this review article is to provide important recent updates on the various nanotechnology-base approaches for periodontal disease therapy. The roles of these recently investigated approaches in the disease treatment are also covered in the review.

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Recent approaches for the treatment of periodontitis

Cited by 199 publications

References 77 publications

Bioavailability enhancers of herbal origin: An overview

Bioavailability enhancers of herbal origin: An overview

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

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