Recent Bio-Advances in Metal-Organic Frameworks

Abstract

Metal-organic frameworks (MOFs) have found uses in adsorption, catalysis, gas storage and other industrial applications. Metal Biomolecule Frameworks (bioMOFs) represent an overlap between inorganic, material and medicinal sciences, utilising the porous frameworks for biologically relevant purposes. This review details advances in bioMOFs, looking at the synthesis, properties and applications of both bioinspired materials and MOFs used for bioapplications, such as drug delivery, imaging and catalysis, with a focus on examples from the last five years.

The Current Status of MOF and COF Applications

“…The"Radio-immuno Metal-Organic" (RiMO) compound RiMO-301 (Rimo Therapeutics Inc.) was the first therapeutic MOF compound administered to human patients in aPhase Iclinical trial. [42] Theintrinsically nontoxic RiMO-301 scaffold enhances the efficacyo fX -ray radiotherapy by serving as ar adio-sensitizing agent after intratumoral injection and irradiation. Shortly thereafter,two additional antitumoral nanoscale coordination polymers, CPI-100 and CPI-200 (Coordination Pharmaceuticals,I nc.…”

“…Specifically,t he phase Ic linical trial of aR iMO-301 radio-immunotherapy against advanced tumors in human patients has successfully been initiated as the first MOF-in-human clinical study. [42] Finally,t he application of MOF-based devices has revolutionized the area of water harvesting due to their superiority over alternative materials in arid climates. [43] This Review will focus on the impressive progress in harnessing the unique MOF and COF properties in various fields of application such as gas separation and storage,vapor adsorption, catalysis,c hemical sensing,b iomedical applications,a nd ionic conductors.W ew ish to spotlight the large application potential of these reticular materials by presenting the milestones that have propelled the research in this field into novel and unexpected realms of material chemistry.…”

“…Apart from significant advances in gas storage applications, accomplishments in medicine have been demonstrated, as well. Specifically, the phase I clinical trial of a RiMO‐301 radio‐immunotherapy against advanced tumors in human patients has successfully been initiated as the first MOF‐in‐human clinical study [42] . Finally, the application of MOF‐based devices has revolutionized the area of water harvesting due to their superiority over alternative materials in arid climates [43] …”

Der derzeitige Stand von MOF‐ und COF‐Anwendungen

“…Abgesehen von bedeutenden Fortschritten bei Gasspeicheranwendungen wurden auch Erfolge in der Medizin erzielt. Insbesondere wurde die Phase I der klinischen Studie für das Radioimmuntherapeutikum RiMO‐301 gegen fortgeschrittene Tumoren bei menschlichen Patienten erfolgreich eingeleitet – die erste klinische Studie mit MOFs am Menschen [42] . Und schließlich hat die Anwendung von MOF‐basierten Geräten den Bereich der Wassergewinnung aufgrund ihrer Überlegenheit gegenüber alternativen Materialien in trockenem Klima revolutioniert [43] …”

Zinc-Based Metal-Organic Frameworks in Drug Delivery, Cell Imaging, and Sensing

“…There are certain properties associated with MOFs, such as their versatile architecture, increased internal surface area, and ease of tuning their configuration by altering any of their components, i.e., either metal or organic ligand, that make them ideal candidates for applications in drug delivery systems, imaging, and sensors [ 10 ]. Therefore, the selection of components in MOFs should be such that it is environmentally and biologically compatible [ 11 ].…”