Since the 2000s, Lima city shows important changes in its socio-spatial structure, decreasing the long-established opposition between the centre and the periphery, developing a more complex arrangement. Sustained national economic growth has allowed better socio-economic conditions in different areas of the city. However, high inequality still remains in the ways of production of urban space, which affects residential segregation. To identify possible changes in the segregation patterns of Metropolitan Lima, this study focuses on the spatial patterns of occupational groups, examining their causes and relation with income inequality. The analysis is based on the 1993 and 2007 census data, measuring residential segregation by the Dissimilarity Index, comparing with the Diversity Index. The results confirm trends towards increased segregation between occupational groups. Top occupational groups are concentrated in central areas, expanding into adjacent districts. Bottom occupational groups are over-represented in distant neighbourhoods. In-between, a new, more mixed, transitional zone has emerged in upgraded formerly low-income neighbourhoods. Areas of lower occupational diversity coincide with extreme income values, forming spaces of greater segregation. In the metropolitan centre–periphery pattern, the centre has expanded, while the periphery has been shifted to outer peripheral rings.