Recent development of antifouling polymers: structure, evaluation, and biomedical applications in nano/micro‐structures

Liu, Lingyun; Li, Wenchen; Liu, Qingsheng

doi:10.1002/wnan.1278

Cited by 67 publications

(71 citation statements)

References 103 publications

(174 reference statements)

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“…Almost all NPs that are administrated systematically are coated with electrically neutral hydrophobic surface layers called a "stealth coating" which extends the half-life of NPs to >40 h (Moghimi et al, 2001). Administration of NPs via intradermal or subcutaneous injection showed a different distribution depending on the absence or presence of coatings (Hirai et al, 2012;Liu et al, 2014). The degree of NPs coating plays an important factor in reaching targeted tissues (Liu et al, 2014).…”

Section: * Corresponding Authormentioning

confidence: 99%

“…Administration of NPs via intradermal or subcutaneous injection showed a different distribution depending on the absence or presence of coatings (Hirai et al, 2012;Liu et al, 2014). The degree of NPs coating plays an important factor in reaching targeted tissues (Liu et al, 2014). For instance, poly (ethylene) glycol (PEG)-coated NPs reaches the lymphatic vessels and their circulatory system faster than free injected NPs (Liu et al, 2014;Iannazzo et al, 2017).…”

Section: * Corresponding Authormentioning

confidence: 99%

“…The degree of NPs coating plays an important factor in reaching targeted tissues (Liu et al, 2014). For instance, poly (ethylene) glycol (PEG)-coated NPs reaches the lymphatic vessels and their circulatory system faster than free injected NPs (Liu et al, 2014;Iannazzo et al, 2017).…”

Section: * Corresponding Authormentioning

confidence: 99%

“…However, antiangiogenic factors can cause incompatible expansion and defects in the architecture of tumour vasculature (Fukumura and Jain, 2007;Hanahan and Folkman, 1996). Studies using transplanted rodent tumours revealed that the pore size of tumours microvessels range between 100 nm to 780 nm in diameter, therefore; this is an important feature in the extravasation of NPs (Hobbs et al, 1998;Li and Huang, 2010). Additionally, tumours commonly have poor lymphatic drainage, which can reduce the removal of NPs (Maeda et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Some of surface coatings can prevent nanoparticle opsonization and aggregation, improve cellular uptake, increase wettability, and affect degradation rates (Khung and Narducci, 2015). This include polySBMA (sulfobetaine methacrylate), PEG, dextran, chitosan, pullulan, sodium oleate, dodecylamine, polysorbate 80, poloxamer 188, polyvinyl alcohol, poly-2-methyl-2-oxazoline, polyvinylpyrrolidone, and α-tocopherol PEG-1000 succinate (Izquierdo-Barba et al, 2016;Liu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Toxicity of thiolated silica nanoparticles modified with sulfobetaine methacrylate for potential use in chemotherapy drug conjugation

2017

J App Pharm Sci

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Nanoparticles (NPs) are promising substrates for the delivery of chemotherapy drugs to solid tumours. However, after injection these foreign bodies are often eliminated by the reticulo endothelial system (RES) within seconds or minutes. Previous studies overcome this issue by coating nano-drug carriers with a surfactant which extended the circulatory half-life of NPs and prevented opsonization. In the current study, thiolated silica nanoparticles (SiO2) were synthesized using the Stöber method then coated with low fouling zwitterionc sulfobetaine methacrylate (SBMA) using thiol-ene addition. Scanning electron micrographs (SEM) revealed monodispersed spherical particles with dynamic light scattering (DLS) showing a small increase in nanoparticle average diameter after modification with SBMA. Toxicity of the SiO2-SBMA nanoparticles (concentrations between 0.05-2.00mg/mL) was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase (LDH) and crystal violet assays on human colon carcinoma (Caco-2) and human skin keratinocytes (HaCaT) cell lines for 4, 24 and 48 h. The particles were also exposed to ultraviolet light (UV) to determine any possible degradation with zeta potential measurements revealing strongly anionic particles after 1 h UV light exposure. The SiO2-SBMA nanoparticles did not decrease the mitochondrial activity of Caco-2 or HaCaT cell lines using MTT assays; however, the LDH leakage increased and relative cell number decreased at 2.00 mg/mL and was clearly observed after the particles were exposed to UV light. These results indicate that concentrations ≤1.50 mg/mL of SiO2-SBMA low toxicity are biocompatible and show potential as a chemotherapy drug conjugate.

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Section: * Corresponding Authormentioning

confidence: 99%

Section: * Corresponding Authormentioning

confidence: 99%

Section: * Corresponding Authormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Toxicity of thiolated silica nanoparticles modified with sulfobetaine methacrylate for potential use in chemotherapy drug conjugation

2017

J App Pharm Sci

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Antimicrobial Polymer Coating

et al. 2020

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Anti‐Biofouling and Healable Materials: Preparation, Mechanisms, and Biomedical Applications

Liu

Guo

2018

Adv Funct Materials

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Preventing biofouling is challenging for a wide range of biomedical applications. Although materials with good anti-biofouling properties are reported, their antifouling functions are readily lost when detachments or scratches occur through physical damage and chemical degradation by water, oxygen, or possible catalytic ions in water containing reactive environments. Consequently, it is important to develop durable anti-biofouling materials with healing abilities. This review summarizes the important developments in five kinds of antibiofouling materials categorized according to healing mechanisms and material properties in the recent five years, namely structural rearrangement-, reaction-, ionic bond-, and hydrogel-based healing materials, as well as other healable antifouling materials. The healing mechanisms and potential biomedical applications of these healable anti-biofouling materials are emphasized.We focus on the "functional" self-healing, i.e., the recovery of anti-biofouling properties. Five types of anti-biofouling and healable materials are discussed in detail based on the healing mechanisms and material properties. Potentials of these antifouling mechanisms in various biomedical applications and some future perspectives are proposed. Anti-Biofouling and Healable MaterialsThe general requirements of designing antifouling and healable materials are introduced in detail in this section based on healing mechanisms and the materials used. Three types of anti-biofouling and healable materials, namely, structural rearrangement-, reaction-, and ionic bond-based antifouling healable materials were classified based on the healing mechanisms. Additionally, hydrogel-based antifouling self-healing materials were listed as a specific class of materials. Each item was discussed and summarized in Table 1 with several recent examples reported by various research groups. In addition, some other antifouling healable materials were also introduced briefly.Generally, the healing process is characterized by morphology-based methods such as rheology, tensile tests, and cut-/scratch-healing tests with the assistance of scanning electron microscopy (SEM), optical microscope images, and atomic force microscopy (AFM), which also quantify the healing efficiency. Infrared (IR) spectroscopy or linear Raman spectra can monitor the formation or cleavage of chemical bonds and supramolecular interactions in the healing process. Recently, Popp and co-workers proposed that coherent anti-Stokes Raman scattering, a nonlinear Raman variant can be used as molecular characterization of healing process. It acquires morphological and molecular information simultaneously and thus offers a different observation from conventional morphological-based methods. [12] The anti-biofouling properties are usually evaluated by wettability measurements as well as the resistance ability to proteins, cells, bacteria, algas, and other microorganisms. In the wettability measurements, contact angle (CA) and contact angle hysteresis (CAH) experiments are used ...

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Recent development of antifouling polymers: structure, evaluation, and biomedical applications in nano/micro‐structures

Cited by 67 publications

References 103 publications

Toxicity of thiolated silica nanoparticles modified with sulfobetaine methacrylate for potential use in chemotherapy drug conjugation

Toxicity of thiolated silica nanoparticles modified with sulfobetaine methacrylate for potential use in chemotherapy drug conjugation

Antimicrobial Polymer Coating

Anti‐Biofouling and Healable Materials: Preparation, Mechanisms, and Biomedical Applications

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