Recent development of nucleic acid nanosensors to detect sequence-specific binding interactions: From metal ions, small molecules to proteins and pathogens

Zheng, Xin Ting; Tan, Yen Nee

doi:10.1016/j.sintl.2020.100034

Cited by 27 publications

(13 citation statements)

References 86 publications

(115 reference statements)

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“…as well as pathogenic species such as multidrug-resistant bacteria, coronaviruses, etc. for medical diagnosis. , Biometal NPs have been used in designing electrochemical and optical biosensors, owing to their unique conductivity and LSPR properties (i.e., size-dependent color and microenvironment-dependent fluorescence signal changes). ,,− This section focuses on the versatile designs of metallic nanobiosensors for detecting various biomarkers, including small molecules, DNA, proteins, bacteria, and viruses.…”

Section: Biomedical Applications Of Biometal Nanoparticlesmentioning

confidence: 99%

Biomimetic Metallic Nanostructures for Biomedical Applications, Catalysis, and Beyond

Yaraki

Nasab

Zare³

et al. 2022

Ind. Eng. Chem. Res.

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Nature has inspired scientists to develop green and sustainable nanomaterials with biomimetic functions. Particularly, biomimetic metallic nanostructures (biometal NPs) with unique optical, catalytic, and electrical properties have received tremendous attention in many fields, ranging from healthcare and agriculture to energy and environmental sciences. Biometal NPs synthesized by various natural resources such as plant extracts, biomolecules, bacteria, and even viruses possess unique biomimetic functions including but not limited to precise biorecognition, selfassembly, antibacterial/antiviral, and enzymatic properties. In this report, we first review the bioinspired synthesis of industrially important metal nanoparticles, followed by the discussion on how the different biological sources affect the biomimetic functions of the as-synthesized biometal NPs. Next, we review the recent advancement and applications of these biometal NPs in the fields of biomedical engineering and catalysis, which include the development of metallic nanobiosensors, biomedical imaging probes, nanotherapeutics (e.g., antimicrobial and photodynamic/photothermal therapeutic agents), as well as the design of multifunctional nanozymes and artificial metalloenzymes for chemical and biopharmaceutical industries. Finally, we highlight some of the latest advancements in nanobiomimicry and their emerging applications in clean energy, electronic devices, and data storage, which shows the game-changing role of biomimetic metallic nanostructures for various technological applications in the near future.

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Section: Biomedical Applications Of Biometal Nanoparticlesmentioning

confidence: 99%

Biomimetic Metallic Nanostructures for Biomedical Applications, Catalysis, and Beyond

Yaraki

Nasab

Zare³

et al. 2022

Ind. Eng. Chem. Res.

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“…Molecular biology detection technology is based on nucleic acid, through the detection of specific target pathogens DNA or RNA for detection purposes ( Xi et al, 2014 ; Liu et al, 2017a ; Foddai and Grant, 2020 ; Zheng and Tan, 2020 ; Kim and Oh, 2021 ). It is achieved by hybridizing the target sequence with complementary probes or primers ( Yang et al, 2014b ; Yang et al, 2017 ; Chen et al, 2020a ; Wachiralurpan et al, 2020 ).…”

Section: Molecular Biology Detection Technologymentioning

confidence: 99%

Research progress on detection techniques for point-of-care testing of foodborne pathogens

Zhao

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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The global burden of foodborne disease is enormous and foodborne pathogens are the leading cause of human illnesses. The detection of foodborne pathogenic bacteria has become a research hotspot in recent years. Rapid detection methods based on immunoassay, molecular biology, microfluidic chip, metabolism, biosensor, and mass spectrometry have developed rapidly and become the main methods for the detection of foodborne pathogens. This study reviewed a variety of rapid detection methods in recent years. The research advances are introduced based on the above technical methods for the rapid detection of foodborne pathogenic bacteria. The study also discusses the limitations of existing methods and their advantages and future development direction, to form an overall understanding of the detection methods, and for point-of-care testing (POCT) applications to accurately and rapidly diagnose and control diseases.

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“…Some of them include nanosensors for detecting metal ions and pathogens, including various bacteria and viruses. This detection is based on utilizing techniques for high-throughput screening technologies such as surface-enhanced Raman spectroscopy (SERS), colorimetric, dynamic light scattering (DLS), as well as fluorescence and electrochemical detections, to name just a few [ 255 ]. These new developments greatly assist not only drug discovery methods, but also mass screening which is critical at times of pandemics such as SARS-CoV-2.…”

Section: Further Characteristics and Areas Of Applicationsmentioning

confidence: 99%

Coupled Multiphysics Modelling of Sensors for Chemical, Biomedical, and Environmental Applications with Focus on Smart Materials and Low-Dimensional Nanostructures

Singh

Melnik

2022

Chemosensors

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Low-dimensional nanostructures have many advantages when used in sensors compared to the traditional bulk materials, in particular in their sensitivity and specificity. In such nanostructures, the motion of carriers can be confined from one, two, or all three spatial dimensions, leading to their unique properties. New advancements in nanosensors, based on low-dimensional nanostructures, permit their functioning at scales comparable with biological processes and natural systems, allowing their efficient functionalization with chemical and biological molecules. In this article, we provide details of such sensors, focusing on their several important classes, as well as the issues of their designs based on mathematical and computational models covering a range of scales. Such multiscale models require state-of-the-art techniques for their solutions, and we provide an overview of the associated numerical methodologies and approaches in this context. We emphasize the importance of accounting for coupling between different physical fields such as thermal, electromechanical, and magnetic, as well as of additional nonlinear and nonlocal effects which can be salient features of new applications and sensor designs. Our special attention is given to nanowires and nanotubes which are well suited for nanosensor designs and applications, being able to carry a double functionality, as transducers and the media to transmit the signal. One of the key properties of these nanostructures is an enhancement in sensitivity resulting from their high surface-to-volume ratio, which leads to their geometry-dependant properties. This dependency requires careful consideration at the modelling stage, and we provide further details on this issue. Another important class of sensors analyzed here is pertinent to sensor and actuator technologies based on smart materials. The modelling of such materials in their dynamics-enabled applications represents a significant challenge as we have to deal with strongly nonlinear coupled problems, accounting for dynamic interactions between different physical fields and microstructure evolution. Among other classes, important in novel sensor applications, we have given our special attention to heterostructures and nucleic acid based nanostructures. In terms of the application areas, we have focused on chemical and biomedical fields, as well as on green energy and environmentally-friendly technologies where the efficient designs and opportune deployments of sensors are both urgent and compelling.

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Recent development of nucleic acid nanosensors to detect sequence-specific binding interactions: From metal ions, small molecules to proteins and pathogens

Cited by 27 publications

References 86 publications

Biomimetic Metallic Nanostructures for Biomedical Applications, Catalysis, and Beyond

Biomimetic Metallic Nanostructures for Biomedical Applications, Catalysis, and Beyond

Research progress on detection techniques for point-of-care testing of foodborne pathogens

Coupled Multiphysics Modelling of Sensors for Chemical, Biomedical, and Environmental Applications with Focus on Smart Materials and Low-Dimensional Nanostructures

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