Recent development of small-molecule fluorescent probes based on phenothiazine and its derivates

Fluorescence Imaging of Diabetic Cataract-Associated Lipid Droplets in Living Cells and Patient-Derived Tissues

“…In addition, oleic acid was spiked into water to mimic LDs, and continuous fluorescence amplification was observed at 606 nm (Figure 1D), suggesting that PTZ-LD might emit a bright fluorescence in LDs. Since PTZ is usually susceptible to reactive oxygen species (ROS), 48 , homocysteine (Hcy), cysteine (Cys), and glutathione (GSH)) confirmed the stability of the C�C double bond (Figure S3). Therefore, PTZ-LD shows superb chemostability.…”

“…In addition, oleic acid was spiked into water to mimic LDs, and continuous fluorescence amplification was observed at 606 nm (Figure D), suggesting that PTZ-LD might emit a bright fluorescence in LDs. Since PTZ is usually susceptible to reactive oxygen species (ROS), we then added 10 equiv of various ROS (H 2 O 2 , ONOO – , O 2 •– , t BuOOH, •OH, and ClO – ) to the probe solution in PBS, and neglectable intensity changes were monitored. Additionally, the unchanged fluorescence intensity in the presence of nucleophilic reactive sulfur species (S 2– , SO 3 2– , homocysteine (Hcy), cysteine (Cys), and glutathione (GSH)) confirmed the stability of the CC double bond (Figure S3).…”

Synthesis, characterization & catalysis of ITQ 2D metal–organic frameworks and spectroscopic & photodynamic properties of their composites with organic dyes

“…, high photoluminescence quantum yield and large Stokes shift) and the fact that their luminescence characteristics strongly depend on the surrounding environment, turning these molecules into ideal candidates for developing luminescence-based sensors. 73–76 Nile red (NR, Fig. 11a) and trans -4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4 H -pyran (DCM, Fig.…”

Phenothiazine appended thiophene derivative: a trilateral approach to copper ion detection in living cells and aqueous samples

“…The remarkable optical properties of phenothiazine derivatives have led to extensive research into their applications in diverse biological activities and metal ion detection. 19 Thus, in such a context, we successfully synthesized the phenothiazine-thiophene acetonitrile compound PTZ-SCN through a simple Knoevenagel condensation reaction. 20,21 The newly synthesized PTZ-SCN demonstrated sensitivity and selectivity towards Cu 2+ in both simulated physiological conditions (CH 3 CN : HEPES buffer) and within cells.…”