Recent developments in astaxanthin production from Phaffia rhodozyma and its applications

Zhuang, Yuan; Zhu, Ming‐Jun

doi:10.1016/b978-0-12-823304-7.00006-4

Cited by 7 publications

(4 citation statements)

References 109 publications

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“…FW is rich in nutrients, such as carbohydrates, proteins, fats, and minerals, and astaxanthin is known as a natural colorant and feed additive in aquaculture. 3 Fish meal, soybean meal, rapeseed meal, and cottonseed meal are commonly used as protein feed ingredients in Chinese aquaculture. 35 The basic nutrients and trace elements of fermentation products of FW are shown in Tables 4 and 5.…”

Section: Contents Of Nutrientsmentioning

confidence: 99%

“…Therefore, improving astaxanthin yield and reducing the cost of fermentation are prerequisites for the development of astaxanthin industrialization. 3 The mutation methods of UV 3 N-methyl-N′-nitro-Nnitrosoguanidine (MNNG) 5 atmospheric and room temperature plasma, 6 low-energy ion beam implantation, and low-dose gamma irradiation 7 were successfully used to obtain P. rhodozyma mutants with high pigment production. Among them, UV mutagenesis has advantages of simplicity, low risk, and no need for genetic engineering.…”

Section: Introductionmentioning

confidence: 99%

“…It is reported that the market value of astaxanthin is expected to be 1 billion US dollars in 2025 2 . Astaxanthin from Phaffia rhodozyma is one of the natural sources of astaxanthin, but astaxanthin content in P. rhodozyma is only 0.02%–0.04% (w/w), 3 and the culture temperature of P. rhodozyma is 17–22°C, 4 which limits the industrial production of astaxanthin by P. rhodozyma . Therefore, improving astaxanthin yield and reducing the cost of fermentation are prerequisites for the development of astaxanthin industrialization 3 …”

Section: Introductionmentioning

confidence: 99%

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Enhancement of astaxanthin production from food waste by Phaffia rhodozyma screened by flow cytometry and feed application potential

Lai

Liu

et al. 2023

Biotech and App Biochem

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Astaxanthin is widely used in food, aquaculture, cosmetics, and pharmaceuticals due to its strong antioxidant activity and coloring ability, but its production from Phaffia rhodozyma remains the main challenge due to the high fermentation cost and low content of carotenoid. In this study, the production of carotenoids from food waste (FW) by a P. rhodozyma mutant was investigated. P. rhodozyma mutant screened by UV mutagenesis and flow cytometry could stably produce high carotenoids at 25°C, with carotenoid production (32.9 mg/L) and content (6.7 mg/g), respectively, increasing by 31.6% and 32.3% compared with 25 mg/L and 5.1 mg/g of wild strain. Interestingly, the carotenoid production reached 192.6 mg/L by feeding wet FW, which was 21% higher than batch culture. The 373 g vacuum freeze‐dried products were obtained from the fermentation of 1 kg FW by P. rhodozyma, which contained 784 mg carotenoids and 111 mg astaxanthin. The protein, total amino acids, and essential amino acids content of the fermentation products were 36.6%, 40.5%, and 18.2% (w/w), respectively, and lysine‐added fermentation products had the potential of high‐quality protein feed source. This study provides insights for the high‐throughput screening of mutants, astaxanthin production, and the development of the feed potential of FW.

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Section: Contents Of Nutrientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhancement of astaxanthin production from food waste by Phaffia rhodozyma screened by flow cytometry and feed application potential

Lai

Liu

et al. 2023

Biotech and App Biochem

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“…Aquatic animals have principally low ability to biochemically synthesize astaxanthin de novo and thus require it as a part of dietary supplementation for immune‐physiological functions (Basiony et al., 2022; Fang et al., 2019). Although freshwater green microalga Haematococcus pluvialis and pink yeast Phaffia rhodozyma are the main sources of natural astaxanthin (Niizawa et al., 2021; Zhuang & Zhu, 2021), over 95% of available astaxanthin in the market is produced synthetically (Hu, 2019). It has been reported that the antioxidant activity of natural astaxanthin is 50 times higher than the synthetic forms (Capelli et al., 2013) and at least 10 times higher than that of other carotenoids (Dufossé, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary nanoliposome‐coated astaxanthin on haematological parameters, immune responses and the antioxidant status of rainbow trout (Oncorhynchus mykiss)

Besharat,

Islami,

Soltani

et al. 2024

Veterinary Medicine & Sci

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BackgroundAstaxanthin is the most prevalent carotenoid in the marine environment and is widely used as an additive in formulated aquafeeds.ObjectivesA 60‐day feeding trial was conducted to consider the effect of dietary nanoliposome‐coated astaxanthin (NA) on haematological parameters, serum antioxidant activities and immune responses of rainbow trout, Oncorhynchus mykiss.MethodsA total of 450 healthy fish weighing 31.00 ± 2.09 g were randomly assigned in triplicate (30 fish per replicate) to 5 dietary treatments: 0 (control), 25.00, 50.00, 75.00, and 100.00 mg kg−1 NA.ResultsFish fed the diet supplemented with 50.00 mg kg−1 NA exhibited the highest values of red blood cells, white blood cells, haemoglobin and haematocrit of 1.64 ± 0.01 × 106 mm−3, 5.54 ± 0.21 × 103 mm−3, 8.73 ± 0.24 g dL−1 and 46.67% ± 0.88%, respectively, which were significantly higher than those fed the basal diet (p < 0.05). The lowest and highest percentages of lymphocytes (67.67% ± 0.33%) and neutrophils (27.33% ± 1.20%) were also obtained in fish fed 50.00 mg kg−1 NA compared to those fed the basal diet (p < 0.05). Fish receiving diet supplemented with 50.00 mg kg−1 NA revealed the highest serum activity in superoxide dismutase, catalase, glutathione peroxidase, lysozyme and alternative complement and the lowest level of total cholesterol, cortisol, aspartate aminotransferase and alanine aminotransferase than fish receiving the basal diet (p < 0.05). Serum immunoglobulin (Ig) and ACH50 contents significantly increased with increasing dietary NA supplementation to the highest values of 43.17 ± 1.46 and 293.33 ± 2.03 U mL−1, respectively, in fish fed diet supplemented with 50 mg kg−1 NA (p < 0.05).ConclusionsSupplementation of NA in rainbow trout diet at 50 mg kg−1 exhibited a positive effect on haematological parameters, antioxidant capacity and immune responses. Administration of such dosage can enhance rainbow trout immune responses against unfavourable or stressful conditions, for example disease outbreaks, hypoxic condition, thermal stress and sudden osmotic fluctuations, which usually happen in an intensive culture system.

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Enhancing astaxanthin yield in Phaffia rhodozyma: current trends and potential of phytohormones

Nutakor¹,

Kanwugu

Kovaleva

et al. 2022

Appl Microbiol Biotechnol

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Recent developments in astaxanthin production from Phaffia rhodozyma and its applications

Cited by 7 publications

References 109 publications

Enhancement of astaxanthin production from food waste by Phaffia rhodozyma screened by flow cytometry and feed application potential

Enhancement of astaxanthin production from food waste by Phaffia rhodozyma screened by flow cytometry and feed application potential

Effects of dietary nanoliposome‐coated astaxanthin on haematological parameters, immune responses and the antioxidant status of rainbow trout (Oncorhynchus mykiss)

Enhancing astaxanthin yield in Phaffia rhodozyma: current trends and potential of phytohormones

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