Recent developments in biodegradable synthetic polymers

Gunatillake, Pathiraja A.; Mayadunne, Roshan T. A.; Adhikari, Raju

doi:10.1016/s1387-2656(06)12009-8

Cited by 387 publications

(253 citation statements)

References 199 publications

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“…Previous in-vitro analysis of this polyesterurethane indicated that no cytotoxic residues are present on the mesh or film scaffolds post-processing and that both constructs accommodate good cell viability 13 . Furthermore, degradation of the 21 monomers within this polyesterurethane, namely hydroxybutyrate, glycolide and ε-caprolactone, are all removed via systemic circulation; poly(hydroxybutyrate) degrades into R-3-hydroxybutyric acid which is a natural component of the blood 33 , while glycolide is removed via renal excretion 34 , as is ε-caprolactone 35 .…”

Section: Discussionmentioning

confidence: 99%

Structural variants of biodegradable polyesterurethane in vivo evoke a cellular and angiogenic response that is dictated by architecture

et al. 2009

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The aim of this study was to investigate an in-vivo tissue response to a biodegradable polyesterurethane, specifically the cellular and angiogenic response evoked by varying implant architectures in a subcutaneous rabbit implant model. A synthetic biodegradable polyesterurethane was synthesised and processed into three different configurations; a non-porous film, a porous mesh and a porous membrane. Glutaraldehyde cross-linked bovine pericardium was used as a control. Sterile polyesterurethane and control samples were implanted subcutaneously in six rabbits, (n=12). The rabbits were sacrificed at 21 and 63 days and the implant sites were sectioned and histologically stained using haemotoxylin and eosin (H&E), Masson's trichrome, picosirius red and immunostain CD31. The tissue-implant interface thickness was measured from the H&E slides.Stereological techniques were used to quantify the tissue reaction at each time point that included volume fraction of inflammatory cells, fibroblasts, fibrocytes, collagen and the degree of vascularisation. Stereological analysis inferred that porous scaffolds with regular topography are better tolerated in-vivo compared to non-porous scaffolds, while increasing scaffold porosity promotes angiogenesis and cellular infiltration. The results suggest that this biodegradable polyesterurethane is better tolerated in-vivo than the control and that structural variants of biodegradable polyesterurethane in-vivo evoke a cellular and angiogenic response that is dictated by architecture.

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Section: Discussionmentioning

confidence: 99%

Structural variants of biodegradable polyesterurethane in vivo evoke a cellular and angiogenic response that is dictated by architecture

et al. 2009

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“…The poly( -esters), including polylactic acid (PLA), polyglycolic acid (PGA), and their copolymers (PLGA), are thermoplastic polymers incorporated in a variety of FDA-approved biomedical devices, including surgical sutures, orthopedic fixation, and drug and growth factor delivery (3). Scaffolds prepared from other thermoplastic biomaterials, such as tyrosine-derived polycarbonates and polyphosphazenes, have been shown to exhibit tunable degradation to non-cytotoxic decomposition products, high tensile strength, and bone tissue ingrowth in vivo (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Injectable Biodegradable Polyurethane Scaffolds with Release of Platelet-derived Growth Factor for Tissue Repair and Regeneration

et al. 2008

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Purpose-The purpose of this work was to investigate the effects of triisocyanate composition on the biological and mechanical properties of biodegradable, injectable polyurethane scaffolds for bone and soft tissue engineering.Methods-Scaffolds were synthesized using reactive liquid molding techniques, and were characterized in vivo in a rat subcutaneous model. Porosity, dynamic mechanical properties, degradation rate, and release of growth factors were also measured.Results-Polyurethane scaffolds were elastomers with tunable damping properties and degradation rates, and they supported cellular infiltration and generation of new tissue. The scaffolds showed a two-stage release profile of platelet-derived growth factor, characterized by a 75% burst release within the first 24 h and slower release thereafter.Conclusions-Biodegradable polyurethanes synthesized from triisocyanates exhibited tunable and superior mechanical properties compared to materials synthesized from lysine diisocyanates. Due to their injectability, biocompatibility, tunable degradation, and potential for release of growth factors, these materials are potentially promising therapies for tissue engineering.

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“…89 Poly lactic-co-glycolic acid is one of the most widely used synthetic polymers. 90 The disadvantages of the synthetic scaffolds are minimal cell adherence and lack of epitopes for cell attachment. There are various techniques used to manufacture scaffolds for the subretinal space, such as particulate leaching, electrospinning and freeze drying, microfabrication, and solvent casting, the last 2 being the most used.…”

Section: Scaffold Material Fabrication Technique and Propertiesmentioning

confidence: 99%

Induced Pluripotent Stem Cell Therapies for Degenerative Disease of the Outer Retina: Disease Modeling and Cell Replacement

Foggia

Makwana

Ali³

et al. 2016

Journal of Ocular Pharmacology and Therapeutics

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Stem cell therapies are being explored as potential treatments for retinal disease. How to replace neurons in a degenerated retina presents a continued challenge for the regenerative medicine field that, if achieved, could restore sight. The major issues are: (i) the source and availability of donor cells for transplantation; (ii) the differentiation of stem cells into the required retinal cells; and (iii) the delivery, integration, functionality, and survival of new cells in the host neural network. This review considers the use of induced pluripotent stem cells (iPSC), currently under intense investigation, as a platform for cell transplantation therapy. Moreover, patientspecific iPSC are being developed for autologous cell transplantation and as a tool for modeling specific retinal diseases, testing gene therapies, and drug screening.

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Recent developments in biodegradable synthetic polymers

Cited by 387 publications

References 199 publications

Structural variants of biodegradable polyesterurethane in vivo evoke a cellular and angiogenic response that is dictated by architecture

Structural variants of biodegradable polyesterurethane in vivo evoke a cellular and angiogenic response that is dictated by architecture

Injectable Biodegradable Polyurethane Scaffolds with Release of Platelet-derived Growth Factor for Tissue Repair and Regeneration

Induced Pluripotent Stem Cell Therapies for Degenerative Disease of the Outer Retina: Disease Modeling and Cell Replacement

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