Recent Developments in Extracellular Matrix Remodeling for Fat Grafting

Bi, Xin; Li, Ye; Dong, Ziqing; Zhao, Jing; Wu, Weizi; Zou, Jialiang; Guo, Lingling; Lu, Feng; Gao, Jianhua

doi:10.3389/fcell.2021.767362

Cited by 9 publications

(7 citation statements)

References 199 publications

(272 reference statements)

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“…Type I and Type II collagen are two important proteins in adipose ECM, providing the complex scaffold to sustain the function and structure of stromal cells [ 30 , 31 ]. A decrease in the synthesis of COL1A1 and COL2A1 in ADSCs suggests that oxidative stress affects adipose ECM remodeling [ 32 ]. PPAR-γ is concerned with the differentiation and maintenance of mature adipocytes and is therefore critical in the formation of adipocytes [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway

Yang

Guo

Yue

et al. 2023

IJMS

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The survival of free fat grafts is dependent primarily on adipose-derived stem cells (ADSCs); however, ADSCs are susceptible to oxidative stress in the recipient area. Astaxanthin (Axt) is a natural xanthophyll carotenoid with potent antioxidant properties and numerous clinical applications. To date, the therapeutic potential of Axt in fat grafting has not been explored. The purpose of this study is to investigate the effects of Axt on oxidatively stressed ADSCs. An oxidative model of ADSCs was developed to simulate the host’s microenvironment. Oxidative insult decreased the protein levels of Cyclin D1, type I collagen alpha 1 (COL1A1), and type II collagen alpha 1 (COL2A1), while increasing the expression of cleaved Caspase 3 and secretion of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in ADSCs. Axt pre-treatment significantly reduced oxidative stress, increased the synthesis of an adipose extracellular matrix, alleviated inflammation, and restored the impaired adipogenic potential in the present model. Furthermore, Axt immensely activated the NF-E2-related factor 2 (Nrf2) pathway, and ML385, an inhibitor of Nrf2, could negate Axt’s protective effects. Additionally, Axt alleviated apoptosis by inhibiting bcl-2-associated X protein (BAX)/Caspase 3 signaling and improving the mitochondrial membrane potential (MMP), which could also be abolished by ML385. Our results suggest that Axt may exert its cytoprotective effect on ADSCs through the Nrf2 signaling pathway and could be therapeutic in fat grafting.

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Section: Discussionmentioning

confidence: 99%

Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway

Yang

Guo

Yue

et al. 2023

IJMS

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“…ECM remodeling-rapid and quality remodeling of the ECM after fat grafting can happen by promoting neovascularization, regulating stem cell differentiation, and suppressing chronic inflammation [207].…”

Section: Autologous Mscs Obtained By Liposuction From the Inner Face ...mentioning

confidence: 99%

Adipose-Derived Stem Cells: Angiogenetic Potential and Utility in Tissue Engineering

Biniazan,

Stoian,

Haykal

2024

IJMS

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Adipose tissue (AT) is a large and important energy storage organ as well as an endocrine organ with a critical role in many processes. Additionally, AT is an enormous and easily accessible source of multipotent cell types used in our day for all types of tissue regeneration. The ability of adipose-derived stem cells (ADSCs) to differentiate into other types of cells, such as endothelial cells (ECs), vascular smooth muscle cells, or cardiomyocytes, is used in tissue engineering in order to promote/stimulate the process of angiogenesis. Being a key for future successful clinical applications, functional vascular networks in engineered tissue are targeted by numerous in vivo and ex vivo studies. The article reviews the angiogenic potential of ADSCs and explores their capacity in the field of tissue engineering (TE).

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“…It was demonstrated by that the co-injection of non-invasive pancreatic cancer cells with CAFs into rats, the cancer cells became metastatic [ 56 ]. Furthermore, the expressions of the matrix metalloproteinases (MMPs) in the surrounding of pancreatic cancer lesions are increased, which accelerate the degradation of collagen IV and laminin for ECM remodeling [ 57 , 58 ]. Although roles of CAFs in pancreatic cancer development have not been fully understood, studies using cell lines and mouse models demonstrated that putative cells carrying CAF markers cooperated with cancerous cells, which played important roles in establishing anti-neoplastic drug resistance [ 54 ].…”

Section: Tumor Microenvironment and Immune Suppression In Pancreatic ...mentioning

confidence: 99%

A comprehensive review of pancreatic cancer and its therapeutic challenges

Jiang

Fagman

et al. 2022

Aging

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Pancreatic cancer is a devastating and lethal human malignancy with no curable chemo-treatments available thus far. More than 90% of pancreatic tumors are formed from ductal epithelium as pancreatic ductal adenocarcinoma (PDAC), which often accompany with the expression of mutant K-ras. The incidences of pancreatic cancer are expected to increase rapidly worldwide in the near future, due to environmental pollution, obesity epidemics and etc. The dismal prognosis of this malignancy is contributed to its susceptibility to tumor micro-metastasis from inception and the lack of methods to detect precursor lesions at very early stages of the onset until clinical symptoms occur. In recent years, basic and clinical studies have been making promising progresses for discovering markers to determine the subtypes or stages of this malignancy, which allow effectively implementing personalized therapeutic interventions. The purpose of this review is to discuss the existing knowledge of the molecular mechanisms of pancreatic cancer and the current state of treatment options with the emphasis on targeting therapeutic approaches. The specific focuses are on the molecular mechanisms of the disease, identifications of drug resistance, establishment of immune escaping mechanisms as well as potential of targeting identified pathways in combinations with existing chemo-drugs.www.aging-us.com AGINGpancreatic cancer risk and onset. The majority of the incidences of pancreatic cancer occur sporadically and the disease is often accompanied with genetic abnormalities in somatic cells. Studies have indicated that unlike familial cancer syndromes for gastrointestine/colon or breast, pancreatic cancer has very low penetrance with less than 10% of the cases to be linked to a familial setting [3,4]. Among many genetic lesions detected in pancreatic cancer, active mutant K-ras is one that occurs in early stages of pancreatic tumorigenesis, followed by inactivation of several tumor suppressors, including p53, p16 INK4a , and others (such as SMAD4/DPC4, MLH1, LKB1, PRSS1, and BRCA2) [3,4].

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Recent Developments in Extracellular Matrix Remodeling for Fat Grafting

Cited by 9 publications

References 199 publications

Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway

Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway

Adipose-Derived Stem Cells: Angiogenetic Potential and Utility in Tissue Engineering

A comprehensive review of pancreatic cancer and its therapeutic challenges

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