Recent developments in prebiotics to selectively impact beneficial microbes and promote intestinal health

Rastall, Robert A.; Gibson, Glenn R.

doi:10.1016/j.copbio.2014.11.002

Cited by 232 publications

(120 citation statements)

References 48 publications

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“…Substrates that are prebiotics A number of fermentable carbohydrates have been reported to convey a prebiotic effect, but the diet ary pre biotics most extensively documented to have health bene fits in humans are the non digestible oligo saccharides fructans and galactans 30 . These oligosacchar ides are prefer entially metabolized by bifidobacteria 16 .…”

Section: Prebiotic Effect and Selectivitymentioning

confidence: 99%

“…The most effective approaches are those that rely on prevention and recognize that early life strategies that promote a resilient, diverse and healthy microbiota have greatest long term potential to benefit health 81,82 . Evidence for the important relationship between the structure and function of the microbial com munity, prebiotic use and host health has accumulated rapidly over the past decade 20,23,30 . To satisfy the criterion of conferring a health benefit, controlled studies estab lishing direct links between the prebiotic and health are needed in the target host.…”

Section: Conferring a Health Benefitmentioning

confidence: 99%

See 1 more Smart Citation

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Gibson

Hutkins

Sanders³

et al. 2017

Nat Rev Gastroenterol Hepatol

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3,959

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In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to review the definition and scope of prebiotics. Consistent with the original embodiment of prebiotics, but aware of the latest scientific and clinical developments, the panel updated the definition of a prebiotic: a substrate that is selectively utilized by host microorganisms conferring a health benefit. This definition expands the concept of prebiotics to possibly include non-carbohydrate substances, applications to body sites other than the gastrointestinal tract, and diverse categories other than food. The requirement for selective microbiota-mediated mechanisms was retained. Beneficial health effects must be documented for a substance to be considered a prebiotic. The consensus definition applies also to prebiotics for use by animals, in which microbiota-focused strategies to maintain health and prevent disease is as relevant as for humans. Ultimately, the goal of this Consensus Statement is to engender appropriate use of the term 'prebiotic' by relevant stakeholders so that consistency and clarity can be achieved in research reports, product marketing and regulatory oversight of the category. To this end, we have reviewed several aspects of prebiotic science including its development, health benefits and legislation

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Section: Prebiotic Effect and Selectivitymentioning

confidence: 99%

Section: Conferring a Health Benefitmentioning

confidence: 99%

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Gibson

Hutkins

Sanders³

et al. 2017

Nat Rev Gastroenterol Hepatol

Self Cite

3,959

2,428

View full text Add to dashboard Cite

show abstract

“…Research on prebiotics' effects on obesity and inflammation is especially active (5), and one recent meta-analysis suggests that inulin consumption may play a role in weight reduction (6). Studies also suggest that combining prebiotics with probiotics-an approach called synbiotics-may potentiate the effects.…”

Section: Feeding the Beastsmentioning

confidence: 99%

Prebiotics gain prominence but remain poorly defined

Katsnelson¹

2016

Proc. Natl. Acad. Sci. U.S.A.

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“…To support beneficial gut microbiota, non-digestible 63 carbohydrates such as fructo-and galacto-oligosaccharides and inulin are used as prebiotics 64 (Rastall & Gibson, 2015). Inulin is synthesized by several plants and it is commercially used 65 as a food supplement as it alters the balance of colonic bacteria towards a healthier 66 composition (Gibson, Beatty, Wang, & Cummings, 1995;Hamaker & Tuncil, 2014).…”

mentioning

confidence: 99%

Bacterial polysaccharide levan as stabilizing, non-toxic and functional coating material for microelement-nanoparticles

Bondarenko

Ivask

Kahru

et al. 2016

Carbohydrate Polymers

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Recent developments in prebiotics to selectively impact beneficial microbes and promote intestinal health

Cited by 232 publications

References 48 publications

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Prebiotics gain prominence but remain poorly defined

Bacterial polysaccharide levan as stabilizing, non-toxic and functional coating material for microelement-nanoparticles

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