Recent Developments in the Use of Glyconanoparticles and Related Quantum Dots for the Detection of Lectins, Viruses, Bacteria and Cancer Cells

Hernando, Pedro J.; Dedola, Simone; Marín, María J.; Field, Robert A.

doi:10.3389/fchem.2021.668509

Cited by 11 publications

(10 citation statements)

References 78 publications

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“…Notably, gold nanoparticles are not the only nanoparticles systems used to detect lectins; examples include quantum dots and magnetic nanoparticles. 198 Whilst many glycosylated nanoparticle syntheses report direct immobilisation, or short linkers to attach the glycan, this can lead to colloidal stability challenges and irreversible aggregation when in biologically relevant media, such as saline buffers or blood plasma. Hence, the use of polymeric tethers that provide steric stabilisation and act as non-fouling 199 interfaces has been explored.…”

Section: Glycosylated Gold Nanoparticlesmentioning

confidence: 99%

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Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow

et al. 2022

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Section: Glycosylated Gold Nanoparticlesmentioning

confidence: 99%

“…Notably, gold nanoparticles are not the only nanoparticles systems used to detect lectins; examples include quantum dots and magnetic nanoparticles. 198 …”

Section: Glycosylated Gold Nanoparticlesmentioning

confidence: 99%

Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow

et al. 2022

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“…In particular, gold and iron oxide glyconanoparticles have been used as both diagnostic and therapeutic agents in a variety of antitumor research studies. The reader is referred to recent reviews concerning the use of glyconanotechnology in cancer therapy ( 24 , 26 , 28 , 29 , 31 , 32 , 34 , 157 ).…”

Section: Glyco-nanotechnology and Cancer Immunotherapymentioning

confidence: 99%

Glycoconjugate Nanoparticle-Based Systems in Cancer Immunotherapy: Novel Designs and Recent Updates

Barchi

2022

Front. Immunol.

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For many years, cell-surface glycans (in particular, Tumor-Associated Carbohydrate Antigens, TACAs) have been the target of both passive and active anticancer immunotherapeutic design. Recent advances in immunotherapy as a treatment for a variety of malignancies has revolutionized anti-tumor treatment regimens. Checkpoint inhibitors, Chimeric Antigen Receptor T-cells, Oncolytic virus therapy, monoclonal antibodies and vaccines have been developed and many approvals have led to remarkable outcomes in a subset of patients. However, many of these therapies are very selective for specific patient populations and hence the search for improved therapeutics and refinement of techniques for delivery are ongoing and fervent research areas. Most of these agents are directed at protein/peptide epitopes, but glycans–based targets are gaining in popularity, and a handful of approved immunotherapies owe their activity to oligosaccharide targets. In addition, nanotechnology and nanoparticle-derived systems can help improve the delivery of these agents to specific organs and cell types based on tumor-selective approaches. This review will first outline some of the historical beginnings of this research area and subsequently concentrate on the last 5 years of work. Based on the progress in therapeutic design, predictions can be made as to what the future holds for increasing the percentage of positive patient outcomes for optimized systems.

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“…Direct or indirect detection (including imaging, sensory/sensory networks) of radiation, pathogens, and chemicals refers to the detection of viruses, bacteria, DNA, RNA, proteins, and nucleotides to prevent acts of bioterrorism, chemicals, industrial harmful gases, ionizing radiation, but also to other harmful electromagnetic waves, etc. [15][16][17][18][19]45].…”

Section: Nanotechnologies In Civil Securitymentioning

confidence: 99%

Nanotechnology: Reflections on Health Benefits and Risks

Buzdugan¹

2022

JES

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There is a constant increase in the demand for engineers who can transform nanotechnology from a scientific result into a commercial solution. However, new technologies often caused conflicts between those who want to exploit them as soon as possible and those who are waiting to receive absolute proof of safety. Certain types of nanoparticles are well studied and recommended for use in medicine, biology, chemistry, cosmetology, etc. Some nanoparticles are proven to be extremely toxic, with drastically different properties from the same volume compounds. The risks associated with using nanotechnologies and products containing nanoparticles cannot be minimized in the absence of regulations, which would allow adequate control to protect the environment and the population’s health. Companies are also extremely careful in investing in this field as long as there is no transparent regulation, as the ultimate goal is to protect the surrounding environment and society. In this paper, we present an overview of the benefits of nanotechnology in areas that affect human health, as well as the risks that may arise from the early use or ill-will of nanotechnologies.

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Recent Developments in the Use of Glyconanoparticles and Related Quantum Dots for the Detection of Lectins, Viruses, Bacteria and Cancer Cells

Cited by 11 publications

References 78 publications

Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow

Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow

Glycoconjugate Nanoparticle-Based Systems in Cancer Immunotherapy: Novel Designs and Recent Updates

Nanotechnology: Reflections on Health Benefits and Risks

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