Recent Developments on the Total Synthesis of Nakadomarin A

Abstract

Nakadomarin A is an alkaloid belongs to manzamine family having architecturally complex structure and exhibits promising biological activities. To accomplish this target molecule, few novel synthetic strategies have been developed by eminent synthetic chemists. This review will highlight the important and improved synthetic approaches for the total synthesis of natural as well as unnatural isomers of nakadomarin A. All synthetic strategies have been enlightened from the cluster of literatures to develop a more elegant strategy for the molecule in future.

Recent Advances in Total Synthesis of Alkaloids from α,β‐Unsaturated Aldehydes

“…To obtain this target heterocycle different synthetic tactics and strategies have been developed. [25] Takemoto et al established a catalytic asymmetric synthesis of the pentacyclic core of (À )-nakadomarin A (ABCDE). α,β-Unsaturated aldehyde was used as initial substrates in the first stage of the reaction sequence.…”