Recent developments on zinc(ii) metal–organic framework nanocarriers for physiological pH-responsive drug delivery

Abstract

In this review article, we discuss the diverse stimuli achieved upon outside activation from single pH-stimulus-responsive or/and multiple pH-stimuli-responsive viewpoints in the body.

An overview of the development of composites containing Mg and Zn for drug delivery

“…In mesoporous silica nanoparticles (MSNs), the ZnS and ZnO quantum dots, or nanoparticles, are incorporated to cover pores as a component in nanocomposites or cappers [25,[72][73][74]. In addition, ZnO can exhibit various nanostructures such as nanobels, nano rods, nano disks, nano sheets, nano spheres, quantum dots, etc.…”

Biocatalytic Metal–Organic Frameworks: Prospects Beyond Bioprotective Porous Matrices

“…Constructed from metal ions or metal-containing clusters and organic linkers, these porous materials exhibit many superior properties over classical nano-and mesoporous materials such as zeolites, amorphous carbon, and mesoporous silica [1,2] with tunable pore size, tailorable composition and structure, well-defined pore aperture, versatile functionality and high guest loading efficiency. [3] Consequently, MOFs have shown great potential in molecular storage, [4] heterogeneous catalysis, [5] biopharmaceutical delivery, [6,7] gas separations [8] and energy storage applications. [9,10] The coupling of biomolecules, primarily being enzymes, with MOFs has gained increasing interests in the last five years.…”

Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF

“…Unlike conventional drug carriers envisaged so far, e.g., micelles, liposomes, dendrimers, and mesoporous silica nanoparticles (Gillies and Fré chet, 2005;Porter et al, 2007;Senapati et al, 2018;Zhang and Ma, 2013;Zhang et al, 2012), MOFs offer a unique opportunity to modulate the incorporated drug payload and release kinetics by a fine engineering of their pore dimension (size/shape) and a fine-tuning of the nature/strength of the adsorption sites decorating their internal pore walls as well as of the functionalization of their external surfaces (Liang et al, 2019). The high degree of variability targets an efficient encapsulation of a broad range of highly challenging active pharmaceutical ingredients (APIs) in order to enhance their bioavailability and ''shelf life'' Gimé nez-Marqué s et al, 2016;Horcajada et al, 2010;Liu et al, 2019;Luo et al, 2019;Teplensky et al, 2017;Wang et al, 2018;Xiao-Gang et al, 2019;Ya-Pan et al, 2019;Ying et al, 2019). Cargo drug loading in MOFs can be accomplished either by an encapsulation during the synthesis (Doonan et al, 2017;Liang et al, 2015Liang et al, , 2019, or by a post-synthetic infiltration in the porosity of already-formed architectures Horcajada et al, 2010;Teplensky et al, 2017;Wang et al, 2018).…”