Recent findings on the role of fungal products in the treatment of cancer

Shamsaei, Sina; Getso, Muhammad Ibrahim; Ahmadikia, Kazem; Yarahmadi, Maryam; Farahani, Hamed Eraghiye; Aslani, Reza; Mohammadzade, Anita Saleh; Raissi, Driss; Soleimani, Atena; Arghavan, Bahareh; Karami, Sara; Mohseni, Moein; Raiesi, Omid

doi:10.1007/s12094-020-02428-1

Cited by 10 publications

(4 citation statements)

References 38 publications

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“…[194] Furthermore, fungi can be used as vectors for targeted drug delivery. [196] For example, Gujrati et al designed a DOXloaded nanoscale vacuole (Figure 15b). [195] They genetically engineered yeast to exhibit human epidermal growth factor re-ceptor2 (HER2)-specific affibody on the vacuolar membrane (Affi HER2 Vacuole).…”

Section: Engineered Fungi In Tumor Treatmentmentioning

confidence: 99%

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Engineered Microorganisms for Advancing Tumor Therapy

Jia,

Wang,

Lin

et al. 2024

Advanced Materials

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Engineered microorganisms have attracted significant interest as a unique therapeutic platform in tumor treatment. Compared with conventional cancer treatment strategies, engineering microorganism‐based systems provide various distinct advantages, such as the intrinsic capability in targeting tumors, their inherent immunogenicity, in situ production of antitumor agents, and multiple synergistic functions to fight against tumors. Herein, the design, preparation, and application of the engineered microorganisms for advanced tumor therapy are thoroughly reviewed. This review presents a comprehensive survey of innovative tumor therapeutic strategies based on a series of representative engineered microorganisms, including bacteria, viruses, microalgae, and fungi. Specifically, it offers extensive analyses of the design principles, engineering strategies, and tumor therapeutic mechanisms, as well as the advantages and limitations of different engineered microorganism‐based systems. Finally, the current challenges and future research prospects in this field, which can inspire new ideas for the design of creative tumor therapy paradigms utilizing engineered microorganisms and facilitate their clinical applications, are discussed.

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Section: Engineered Fungi In Tumor Treatmentmentioning

confidence: 99%

“…Furthermore, fungi can be used as vectors for targeted drug delivery. [ 196 ] For example, Gujrati et al. designed a DOX‐loaded nanoscale vacuole (Figure 15b).…”

Section: Engineered Fungi In Tumor Treatmentmentioning

confidence: 99%

Engineered Microorganisms for Advancing Tumor Therapy

Jia,

Wang,

Lin

et al. 2024

Advanced Materials

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“…For example, vaccines, sera, mycin, antigens, antitoxins, antisera and antibodies for therapeutic use. They have many advantages such as high efficacy, immunity and benefit in anti-tumor therapy, and have a promising market worldwide [62].…”

Section: Microbial Natural Productsmentioning

confidence: 99%

Research Progress of Natural Drugs for Breast Cancer in the Past 30 Years Based on Bibliometric and Knowledge Graph Analysis

Gao¹,

Yang²,

Xue³

et al. 2023

Preprint

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Breast cancer is one of the most common types of malignant tumors worldwide and the leading cause of cancer-related deaths in women. According to the latest report from the World Health Organization, breast cancer has surpassed lung cancer, becoming the most diagnosed cancer globally. Herein, a systematic, quantitative, and visual analysis of the scientific achievements in natural products research and development for breast cancer over the past 30 years is presented. The study utilizes bibliometric and knowledge graph visualization techniques to analyze the trends, co-occurrence of keywords, cooperative networks, cited literature, and research hotspots in the field. The analysis shows that breast cancer natural drug development involves mutual cooperation between multiple countries, with China, the United States, and India being the most active players. Pharmacology is the discipline with the largest number of articles published in nearly 30 years. The study also reveals that the extraction of drugs from organisms and their metabolites is an important direction in the current development of anticancer drugs. The development of natural medicines for breast cancer together with the mining of genetic knowledge play an important role in treating human breast cancer. The research presented here provides insights into the current state of natural product research and development for breast cancer, and highlights the need for strengthening mutual communication and cooperation between countries and scientific research institutions to enhance the development of breast cancer treatment technologies and natural medicines.

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“…Therefore, new anticancer agents with high efficiency and little or no toxic side effects are urgently needed. Many fungal extracts inhibit tumor growth and metastasis [ [11] , [12] , [13] ]. Grifolin (C 22 H 32 O 2 ; molecular weight: 328) is a terpenoid compound extracted from edible fruiting bodies of the mushroom Albatrellus confluens [ 14 ] .…”

Section: Introductionmentioning

confidence: 99%