2022
DOI: 10.1016/j.drudis.2022.103340
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Recent insights into viral infections as a trigger and accelerator in alzheimer's disease

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Cited by 10 publications
(10 citation statements)
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References 162 publications
(209 reference statements)
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“…As a consequence of COVID-19 and in part because therapies for other targets such as acetylcholine and glutamate excitotoxity have given ambivalent results, there has been renewed interest in the role of viral infections, and not just SARS-CoV-2, in the development of AD, and also the potential preventive benefit of vaccinations ( De Vlieger et al, 2022 ). (SCOPUS data are presented Supplementary Figures S2, 3 for the role of viruses and vaccinations.)…”
Section: Hypotheses and Drug Targetsmentioning
confidence: 99%
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“…As a consequence of COVID-19 and in part because therapies for other targets such as acetylcholine and glutamate excitotoxity have given ambivalent results, there has been renewed interest in the role of viral infections, and not just SARS-CoV-2, in the development of AD, and also the potential preventive benefit of vaccinations ( De Vlieger et al, 2022 ). (SCOPUS data are presented Supplementary Figures S2, 3 for the role of viruses and vaccinations.)…”
Section: Hypotheses and Drug Targetsmentioning
confidence: 99%
“…Two possible answers are summarized in Figure 8 . According to the direct infection hypothesis ( Figure 8A ), the virus directly enters the CNS and causes neuronal death or activates an antiviral response ( Seaks and Wilcock, 2020 ), causing neuroinflammation and AD pathology ( De Vlieger et al, 2022 ). More frequent re-infection produces the greater cumulative damage seen in AD patients ( Itzhaki et al, 2016 ).…”
Section: Hypotheses and Drug Targetsmentioning
confidence: 99%
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“…Investigation of the function of the HSV-1-encoded miRNA, miR-H1, revealed that this miRNA is involved in the silencing of ubiquitin protein ligase E3 component n-recognin 1 (Ubr1). Ubr1 has already been identified as responsible for the degradation of fragments of proteins associated with neurodegeneration, such as β-amyloid and phosphorylated tau [110]. The analysis of the role of miR-H1 during HSV-1 replication and its influence on the regulation of Ubr1 revealed that during HSV-1 replication, miR-H1 was widely expressed and negatively regulated the Ubr1 expression, which may explain why Aβ accumulation occurs after the completion of the HSV-1 replication process.…”
Section: Mir-h1mentioning
confidence: 99%
“…Multimorbidity with insulin resistance, older age, and obesity are the main risk factors not only for AD but also for severe COVID-19 infection [ 28 ], with type 2 diabetes and cardiovascular disease as the leading two comorbidities that worsen COVID-19 pathology. Cognitive impairment, depression, and delirium are possible neurological manifestations of viral infection [ 29 , 30 ], and the long-term consequences of this infection on the prevalence of dementia cannot be estimated yet.…”
Section: Comorbidities Of Admentioning
confidence: 99%