Recent microfluidic advances in submicron to nanoparticle manipulation and separation

Hettiarachchi, Samith; Cha, Haotian; Ouyang, Lingxi; Mudugamuwa, Amith; An, Hongjie; Kijanka, Gregor; Kashaninejad, Navid; Nguyen, Nam‐Trung; Zhang, Jun

doi:10.1039/d2lc00793b

Cited by 48 publications

(33 citation statements)

References 319 publications

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“…Another approach worthy of notice is the recently developed oscillatory inertial [133] and viscoelastic [134] microfluidics that have been demonstrated for the focusing and separation of submicron and nanoscale particles, respectively. This approach may be integrated with other reported submicron/nanoparticle separation methods [135][136][137][138] into one microfluidic device for improved separation. In addition, the nearfield photonic manipulation of nanoparticles [139] may become an integrated part of a multimode separation system.…”

Section: Discussionmentioning

confidence: 99%

Recent advances in multimode microfluidic separation of particles and cells

Song

Xuan

2023

Electrophoresis

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Microfluidic separation of particles and cells is crucial to lab‐on‐a‐chip applications in the fields of science, engineering, and industry. The continuous‐flow separation methods can be classified as active or passive depending on whether the force involved in the process is externally imposed or internally induced. The majority of current separations have been realized using only one of the active or passive methods. Such a single‐mode process is usually limited to one‐parameter separation, which often becomes less effective or even ineffective when dealing with real samples because of their inherent heterogeneity. Integrating two or more separation methods of either type has been demonstrated to offer several advantages like improved specificity, resolution, and throughput. This article reviews the recent advances of such multimode particle and cell separations in microfluidic devices, including the serial‐mode prefocused separation, serial‐mode multistage separation, and parallel‐mode force‐tuned separation.

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Section: Discussionmentioning

confidence: 99%

Recent advances in multimode microfluidic separation of particles and cells

Song

Xuan

2023

Electrophoresis

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“…8,55 We further envisage utilization of microfluidic chips that are specially designed for separation of exosomes (which typically have high and distinct heterogeneity) from cells, body fluids, and other types of extracellular vesicles. 56 Particularly, size exclusionbased double-filtration microfluidic chip with two membranes, having different pore diameters (such as 50 and 200 nm), has been applied for exosome isolation and fractionation from human embryonic kidney cells. 57 Thus, such approaches and through further refinements in microfluidic manufacturing technologies, enabling high precision liquid handling, an efficiency in microscale mixing and a control of timing and flow conditions might resolve separation of typically coexisting small vesicles and micelles of different sizes (in the range 10−50 nm) and shapes from LLC nanodispersions.…”

Section: Future Directionsmentioning

confidence: 99%

“…We further envisage utilization of microfluidic chips that are specially designed for separation of exosomes (which typically have high and distinct heterogeneity) from cells, body fluids, and other types of extracellular vesicles . Particularly, size exclusion-based double-filtration microfluidic chip with two membranes, having different pore diameters (such as 50 and 200 nm), has been applied for exosome isolation and fractionation from human embryonic kidney cells .…”

Section: Future Directionsmentioning

confidence: 99%

Intrinsic and Dynamic Heterogeneity of Nonlamellar Lyotropic Liquid Crystalline Nanodispersions

Yaghmur,

Moghimi

2023

ACS Nano

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Nonlamellar lyotropic liquid crystalline (LLC) nanoparticles are a family of versatile nano-self-assemblies, which are finding increasing applications in drug solubilization and targeted drug delivery. LLC nanodispersions are heterogeneous with discrete nanoparticle subpopulations of distinct internal architecture and morphology, frequently coexisting with micelles and/or vesicles. Diversity in the internal architectural repertoire of LLC nanodispersions grants versatility in drug solubilization, encapsulation, and release rate. However, drug incorporation contributes to the heterogeneity of LLC nanodispersions, and on exposure to biological media, LLC nanodispersions often undergo nanostructural and morphological transformations. From a pharmaceutical perspective, coexistence of multiple types of nanoparticles with diverse structural attributes, together with media-driven transformations in colloidal characteristics, brings challenges in dissecting biological and therapeutic performance of LLC nanodispersions in a spatiotemporal manner. Here, we outline innate and acquired heterogeneity of LLC nanodispersions and discuss technological developments and alternative approaches needed to improve homogeneity of LLC formulations for drug delivery applications.

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“…35 Similarly, by implementing two or more bifurcating junctions, several other magnetic microfluidic devices separate particles based on size, shape, and magnetic susceptibility. 36–40 In addition, such devices are also highly explored for on-demand mixing and quantifying ferrofluid using a micro wall mixer and magnetic actuation, as reported by Broeren group. 41 The application of such devices includes mixing, isolating, trapping, and extracting functionalized magnetic particles, cells, RBC/WBC, and bioactive molecules.…”

Section: Introductionmentioning

confidence: 99%