Recent perspective of polymeric biomaterial in tissue engineering– a review

Khan, Muhammad Umar Aslam; Aslam, Muhammad Azhar; Bin Abdullah, Mohd Faizal; Hasan, Anwarul; Shah, Saqlain A.; Stojanović, Goran M.

doi:10.1016/j.mtchem.2023.101818

Cited by 34 publications

(22 citation statements)

References 248 publications

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“…Perhaps the most potent material for this purpose is hydroxyapatite [ 359 ], with BCP and β-TCP being less resilient to mechanical stress, despite having good properties overall [ 360 ]. As there are still other biomaterials better suitable for soft tissue replacement, and still other biomaterials with untapped potential [ 361 , 362 ], it is very possible that, in the near future, novel approaches for producing biomaterials with a potent antimicrobial action will arise.…”

Section: Discussionmentioning

confidence: 99%

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Periferakis,

Troumpata

et al. 2024

Biomimetics

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The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one of the major complications of such medical interventions. The emergence of novel technologies, especially 3D printing, represents a promising avenue of development for reducing the risk of such eventualities. There are already a host of biomaterials, suitable for 3D printing, that are being tested for antimicrobial properties when they are coated with bioactive compounds, such as antibiotics, or combined with hydrogels with antimicrobial and antioxidant properties, such as chitosan and metal nanoparticles, among others. The materials discussed in the context of this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium phosphate (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), and zirconia. While the recent research results are promising, further development is required to address the increasing antibiotic resistance exhibited by several common pathogens, the potential for fungal infections, and the potential toxicity of some metal nanoparticles. Other solutions, like the incorporation of phytochemicals, should also be explored. Incorporating artificial intelligence (AI) in the development of certain orthopedic implants and the potential use of AI against bacterial infections might represent viable solutions to these problems. Finally, there are some legal considerations associated with the use of biomaterials and the widespread use of 3D printing, which must be taken into account.

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Section: Discussionmentioning

confidence: 99%

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Periferakis,

Troumpata

et al. 2024

Biomimetics

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“…Therefore, research progress in this specic eld can be highly diverse, as demonstrated by the most recent reviews which focus on the nanocomposites of gelatin and various nanoparticles, 1 nano-based biomaterials for leiomyosarcoma therapy, 2 dynamic biomaterials based on material nanoarchitectonics, 3 hydroxyapatite nanoparticles and nanostructured materials, 4 intelligent biomaterials for micro and nanoscale additive manufacturing, 5 nanoscale surface coatings and topographies for neural interfaces, 6 and polymeric drug delivery systems including hydrogels, nanobers, and microspheres. 7,8 In this themed collection, made up of review articles and research papers, the emphasis is rmly placed on the demonstration of links between nano and microscale surface modications, and their effects on mechanical, physical, chemical, and biological properties. The reviews focus on general presentations of surface modications of implants, nanoparticles used in wound healing, ceriabased coatings for biodegradable magnesium alloy, and hydrogels used for bone repair.…”

Section: Andrzej Zieli ńSki * and Beata Majkowska-marzecmentioning

confidence: 99%

“…Therefore, research progress in this specific field can be highly diverse, as demonstrated by the most recent reviews which focus on the nanocomposites of gelatin and various nanoparticles, 1 nano-based biomaterials for leiomyosarcoma therapy, 2 dynamic biomaterials based on material nanoarchitectonics, 3 hydroxyapatite nanoparticles and nanostructured materials, 4 intelligent biomaterials for micro and nanoscale additive manufacturing, 5 nanoscale surface coatings and topographies for neural interfaces, 6 and polymeric drug delivery systems including hydrogels, nanofibers, and microspheres. 7,8…”

mentioning

confidence: 99%

Introduction to the RSC Advances themed collection on nano and microscale modifications of biomaterials

Zieliński,

Majkowska-Marzec

2024

RSC Adv.

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“…Moreover, enormous is the variety of organs such as the liver, kidneys, and pancreas, or tissues such as blood vessels, skin, cartilage, bones, ligaments, and tendons, for which it would be very useful to have effective substitutes. From the early successes of TE, such as the introduction of long-standing commercial skin substitutes [ 10 ] and the construction of bladders [ 11 ], to the more recent achievements, including the replacement and repair of cardiac or nervous tissue [ 12 , 13 , 14 ], the repair of bone defects [ 14 , 15 ], and the bone and dental bone regeneration [ 16 ], progress has been massive both in terms of scaffold characteristics and cell sources, nowadays including also stem cells [ 6 ]. Scaffolds play a pivotal role in TE, being essential both for providing mechanical support to the cells that are forming the new tissue and for defining the dimensions and shape of the tissue itself.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Amine and Aldehyde-Containing Copolymers for Enzymatic Crosslinking of Gelatine

Alfei,

Pintaudi,

Zuccari

2024

IJMS

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In tissue engineering (TE), the support structure (scaffold) plays a key role necessary for cell adhesion and proliferation. The protein constituents of the extracellular matrix (ECM), such as collagen, its derivative gelatine, and elastin, are the most attractive materials as possible scaffolds. To improve the modest mechanical properties of gelatine, a strategy consists of crosslinking it, as naturally occurs for collagen, which is stiffened by the oxidative action of lysyl oxidase (LO). Here, a novel protocol to crosslink gelatine has been developed, not using the commonly employed crosslinkers, but based on the formation of imine bonds or on aldolic condensation reactions occurring between gelatine and properly synthesized copolymers containing amine residues via LO-mediated oxidation. Particularly, we first synthesized and characterized an amino butyl styrene monomer (5), its copolymers with dimethylacrylamide (DMAA), and its terpolymer with DMAA and acrylic acid (AA). Three acryloyl amidoamine monomers (11a–c) and their copolymers with DMAA were then prepared. A methacrolein (MA)/DMAA copolymer already possessing the needed aldehyde groups was finally developed to investigate the relevance of LO in the crosslinking process. Oxidation tests of amine copolymers with LO were performed to identify the best substrates to be used in experiments of gelatine reticulation. Copolymers obtained with 5, 11b, and 11c were excellent substrates for LO and were employed with MA/DMAA copolymers in gelatine crosslinking tests in different conditions. Among the amine-containing copolymers, that obtained with 5 (CP5/DMMA-43.1) afforded a material (M21) with the highest crosslinking percentage (71%). Cytotoxicity experiments carried out on two cell lines (IMR-32 and SH SY5Y) with the analogous (P5) of the synthetic constituent of M21 (CP5/DMAA) had evidenced no significant reduction in cell viability, but proliferation promotion, thus establishing the biocompatibility of M21 and the possibility to develop it as a new scaffold for TE, upon further investigations.

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Recent perspective of polymeric biomaterial in tissue engineering– a review

Cited by 34 publications

References 248 publications

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Introduction to the RSC Advances themed collection on nano and microscale modifications of biomaterials

Synthesis and Characterization of Amine and Aldehyde-Containing Copolymers for Enzymatic Crosslinking of Gelatine

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