2023
DOI: 10.1016/j.jconrel.2023.01.002
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Recent progress and applications of poly(beta amino esters)-based biomaterials

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Cited by 23 publications
(16 citation statements)
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“…Cross-linked poly (beta-amino ester) can be synthesized between amino groups of lysine and acrylate groups of PEGDA in our previous study. 19 Considering the strong π−π and n−π stacking interaction of FFK, the DN FFK/PEGDA hydrogels were in situ synthesized through Michael addition and π−π stacking interactions of FF peptide in this study. Low, medium, and high hydrogels were prepared by heating at 80 °C for six hours.…”
Section: Sequence Design and Characterization Of Peptidesmentioning
confidence: 99%
See 1 more Smart Citation
“…Cross-linked poly (beta-amino ester) can be synthesized between amino groups of lysine and acrylate groups of PEGDA in our previous study. 19 Considering the strong π−π and n−π stacking interaction of FFK, the DN FFK/PEGDA hydrogels were in situ synthesized through Michael addition and π−π stacking interactions of FF peptide in this study. Low, medium, and high hydrogels were prepared by heating at 80 °C for six hours.…”
Section: Sequence Design and Characterization Of Peptidesmentioning
confidence: 99%
“…In this study, hybrid phenylalanine-phenylalanine-lysine (FFK)/polyethylene glycol diacrylate (PEGDA) crosslinked DN hydrogels were synthesized through π–π stacking and Michael addition (Scheme ). Covalent single-network PEGDA/lysine hydrogels were synthesized between amino groups of lysine and acrylate groups of PEGDA via Michael addition in our previous study. FFK, which is similar to lysine with two free amino groups, could also react with acrylate groups of PEGDA to prepare the chemically cross-linked network hydrogels. The diphenylalanine (FF) sequence is the core recognition motif of self-assembled Alzheimer’s disease amyloid-beta. Self assembled peptide-based hydrogels have been extensively studied in the past. The FF sequence with the strong π–π stacking interactions can serve as the physically cross-linked network in the DN hydrogels.…”
Section: Introductionmentioning
confidence: 99%
“…[ 2 ] Accordingly, these advantages mean PBAEs have been widely explored in areas such as drug, gene, and vaccine delivery, particularly when assembled into micelles or polyelectrolyte complexes. [ 1,3–8 ]…”
Section: Introductionmentioning
confidence: 99%
“…[2] Accordingly, these advantages mean PBAEs have been widely explored in areas such as drug, gene, and vaccine delivery, particularly when assembled into micelles or polyelectrolyte complexes. [1,[3][4][5][6][7][8] However, the step-growth polymerization mechanism that yields PBAEs means that structure optimization toward specific applications must either come from the limited amine and diacrylate monomer choice or via end-group modification. Meanwhile other polymerization techniques, such as controlled radical polymerizations or ring opening polymerizations, can easily control block length and sequence for nanoparticle formulation.…”
Section: Introductionmentioning
confidence: 99%
“…Ester compounds are widely used fine chemicals typically used in the food, medicine and chemical industries. 1–3 Generally, esters are prepared by the reaction between organic acids and alcohols, 4 the reaction between carboxylates and halogenated hydrocarbons, 5 and the transesterification of carboxylates with alcohols. 6 However, these conventional methods exhibit disadvantages, including the production of considerable by-products and chemical waste that are deleterious to the environment, severe corrosion of reaction equipment, and harsh reaction conditions.…”
Section: Introductionmentioning
confidence: 99%