Since the physical properties are
similar to native extracellular
matrices, double network (DN) hydrogels have been studied extensively
in the tissue engineering. However, the double chemical crosslinked
DN hydrogel is limited by poor fatigue resistance. π–π
stacking is a non-covalent bonding interaction, which is essential
to maintain and self-assemble the three-dimensional structure of biological
proteins and nucleic acids. In this study, a robust polyethylene glycol
diacrylate (PEGDA)/FFK hybrid DN hydrogel was prepared by Michael
addition and π–π stacking. The hybrid DN hydrogels
with π–π stacking interactions have excellent mechanical
strength and fatigue resistance. The DN FFK/PEGDA hydrogels reveal
great biocompatibility and hemocompatibility. The DN hydrogels containing
π–π stacking have the potential to fabricate robust
hybrid DN hydrogels in drug release and tissue engineering.
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