Recent Progress in Iridium-Catalyzed Enantioselective Hydrogenation: Tetrasubstituted Olefins and Polyenes

Abstract

Iridium-catalyzed enantioselective hydrogenation has become the method of choice to convert prochiral unfunctionalized olefins to optically active compounds. Recently, we reported on applications giving access to more than one stereocenter in a single hydrogenation step. In this account we present recent developments in the hydrogenation of tetrasubstituted unfunctionalized olefins and isoprenoid polyenes, which allow the generation of two stereocenters in a single hydrogenation step.

Perspectives on parity violation in chiral molecules: theory, spectroscopic experiment and biomolecular homochirality

“…The importance of molecular chirality in chemistry can also be exemplied by three special issues of Chimia over the rst decades of the century. One, in 2001 describing the research of a large chemistry department aer moving to new buildings at the start of the century, 17 where a substantial fraction of the research groups worked on subjects with an essential 'chirality' component [18][19][20][21][22][23][24][25][26][27][28][29][30] (and further research at least also partially on chirality aspects), one in 2008, devoted to the chemistry of chirality, [31][32][33][34][35][36][37][38][39][40] and a last one in 2018 (ref. 41) where we might highlight the work on ultracold chiral molecules, 42 new approaches to the determination of absolute conguration, 43 and work on the CISS effect (chiral induced spin selectivity).…”