Recent Progress in Magnetically Actuated Microrobotics for Ophthalmic Therapies

Abstract

Age-related visual loss and ageing demographics account for a large impact on societal health costs on a global scale. Efficient ocular surgery must be precise, safe and cost effective. Current research focuses on robotic systems to assist in ophthalmic surgery. Furthermore, several platforms for drug delivery in the posterior segment of the eye have been introduced. Moreover, magnetic manipulation of tethered and untethered structures has been suggested to assist in teleoperated ophthalmic surgery and targeted drug delivery in the posterior eye due to its many advantages. Magnetic manipulation systems generate magnetic fields and gradients to guide magnetic objects with high precision and force feedback. A hybrid actuation system for guiding a flexible catheter with a sharp edge magnetic tip has been introduced for capsulorhexis – a major step in cataract surgery. Research has demonstrated the potential of wireless magnetic microrobots for targeted drug delivery and simple mechanical operations in the posterior eye segment inex vivoandin vivoexperiments.

Süreksiz Referans Sinyalleri ile İnsan Sinovyal Sıvısında Birden Fazla Biyohibrit Mikrorobotun Hareket Kontrolü için Benzetim Çalışmaları

“…Thus, swarms of microrobots can be utilized in synoval cavity for minimally invasive biomedical applications while the patient, or the joint of interest, is stationary without load for the duration of the procedure. A very comparable promising field of application is ophthalmetry [60] where the eye offers a similar biophysical work environment, i.e., non-Newtonian flow with no motion, inspite of presence of blood vessels. In both cases, the flow field is none existent, except for the field induced by the swarm, and the location of the tissuse renders the procedure easier for relatively weaker magnetic fieds to penetrate in adequate strength to acuate and steer microrobots.…”

Micro/nanorobots for biomedicine: Delivery, surgery, sensing, and detoxification

“…Recent advances in micro/nanorobots have shown considerable promise for addressing these limitations and for using these tiny devices for precision surgery (3,60). Untethered micro/nanorobotic tools, ranging from nanodrillers to micro-grippers and microbullets (Fig.…”

Nanobots for Medicinal Applications

“…Nanobots target many specific health problems as they can navigate to tissues which are hard to reach in the human body. For addressing the limitations of the current surgical procedures and for precision surgery, recent nanobots have shown big promises [38,39]. Untethered nanorobotic tools, ranging from nanodrillers to micro-grippers and microbullets, offer unique capabilities for minimally invasive surgery.…”