Recent progress in preparation of microcapsules with tailored structures for bio-medical applications

Ghiman, Raluca; Pop, Roxana; Rugină, Dumitriţa; Focșan, Monica

doi:10.1016/j.molstruc.2021.131366

Cited by 16 publications

(10 citation statements)

References 139 publications

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“…4 The large error bars are caused mostly by the uncertainty in the capillary diameter value used for calculations (see Supporting Information S.1 for details), to which is added the experimental uncertainty. 5 The average Laplace pressure γ alg /R cap is below 5% of the total pressure gradient Δp tot in all cases. 6 Called fibers in ref 12.…”

Section: Discussionmentioning

confidence: 84%

“…Microencapsulation techniques are used increasingly in industries such as food, cosmetic, pharmaceutical, biomedical, and materials or textile. − A few examples of recent biomedical-oriented microencapsulation research are given in refs − . Certain fields of application require a precise control of the capsule properties (size monodispersity, shape regularity, controlled mechanical properties and porosity, aseptic production, high production rates), which is difficult to satisfy using standard encapsulation technologies such as spray drying or coating.…”

Section: Introductionmentioning

confidence: 99%

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Physical Analysis of the Centrifugal Microencapsulation Process

Badalan

Ghigliotti

Achard

et al. 2022

Ind. Eng. Chem. Res.

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Centrifugal microcapsule synthesis has been shown to be a promising technique for microencapsulation, satisfying at the same time many requirements needed for biomedical applications (controlled monodisperse size, spherical shape, sterile production environment) and allowing a high capsule production rate, using only conventional lab material. Although efforts have been made over the past decade to optimize centrifugal devices, so far only one stage of the capsule synthesis process has been accurately characterized from a physical and mechanical point of view. In this work we provide the first complete description and modeling of the entire centrifugal encapsulation process, by carefully analyzing all its stages using a combined experimental and analytical approach. This results in defining novel global models and a flow diagram of the process. The analysis and models introduced here are expected to contribute to the understanding, design, improvement, and optimal operation of current and future centrifugal microencapsulation devices. Results obtained for void capsules (beads) are confirmed by experiments on capsules with cargo.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Physical Analysis of the Centrifugal Microencapsulation Process

Badalan

Ghigliotti

Achard

et al. 2022

Ind. Eng. Chem. Res.

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“…Artificial microcapsules can be used in various industrial applications, such as in cosmetics (Miyazawa et al 2000;Casanova & Santos 2016), the food industry (Yun, Devahastin & Chiewchan 2021) and biotechnology, where drug targeting is a high-potential application (Ma & Su 2013;Abuhamdan et al 2021;Ghiman et al 2022). Once in suspension in an external fluid, capsules are subjected to hydrodynamics forces, which may lead to large membrane deformation, wrinkle formation or damage.…”

Section: Introductionmentioning

confidence: 99%

“…2021; Ghiman et al. 2022). Once in suspension in an external fluid, capsules are subjected to hydrodynamics forces, which may lead to large membrane deformation, wrinkle formation or damage.…”

Section: Introductionmentioning

confidence: 99%

Data-driven kinematics-consistent model-order reduction of fluid–structure interaction problems: application to deformable microcapsules in a Stokes flow

Dupont

Vuyst²,

Salsac³

2023

J. Fluid Mech.

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In this paper, we present a generic approach of a dynamical data-driven model-order reduction technique for three-dimensional fluid–structure interaction problems. A low-order continuous linear differential system is identified from snapshot solutions of a high-fidelity solver. The reduced-order model uses different ingredients, such as proper orthogonal decomposition, dynamic mode decomposition and Tikhonov-based robust identification techniques. An interpolation method is used to predict the capsule dynamics for any values of the governing non-dimensional parameters that are not in the training database. Then a dynamical system is built from the predicted solution. Numerical evidence shows the ability of the reduced model to predict the time evolution of the capsule deformation from its initial state, whatever the parameter values. Accuracy and stability properties of the resulting low-order dynamical system are analysed numerically. The numerical experiments show very good agreement, measured in terms of modified Hausdorff distance between capsule solutions of the full-order and low-order models, in the case of both confined and unconfined flows. This work is a first milestone to move towards real-time simulation of fluid–structure problems, which can be extended to nonlinear low-order systems to account for strong material and flow nonlinearities. It is a valuable innovation tool for rapid design and for the development of innovative devices.

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“…Microcapsule technology is often used in food, materials, textile, pharmaceutical, cosmetics, pesticides, catalytic, and other elds (Silva et al, 2022;Ghiman et al, 2022). It has outstanding advantages in improving thermostability, oxidative stability, shelf life, etc.…”

Section: Introductionmentioning

confidence: 99%

Capsaicin microcapsules with high encapsulation efficiency and storage stability based on sodium caseinate–acetylated wheat starch: preparation and characterisation

Saleh

Zhang

Liang

et al. 2022

Int J of Food Sci Tech

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To improve the stability of capsaicin, different mass ratios of sodium caseinate and acetylated wheat starch (10:0, 9:1,7:3, 5:5, 3:7, 1:9, 0:10) were used as the wall material to prepare the emulsion, and it was microencapsulated by spray drying technology. The results showed that the sodium caseinate and wheat starch acetate exhibited a perfect emulsi cation effect. The composite wall material could signi cantly improve the encapsulation degree of the whole system, and the highest was 84.05% (3:7). The shape of the capsaicin microcapsule was almost spherical, and the size was not uniform, while the color and dispersion of the particles were consistent. The capsaicin microcapsules had a high solubility between 77.88% and 97.64%. The retention rates of capsaicin prepared with the sodium caseinate/wheat starch acetate ratio were 7:3, 5:5 and 3:7 exhibited high storage stability, which was more than 60.00% after 15 days of storage at different light and temperatures. This study may provide more theoretical support for applying starch acetate in edible vectors and expand the application range of capsaicin.

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Recent progress in preparation of microcapsules with tailored structures for bio-medical applications

Cited by 16 publications

References 139 publications

Physical Analysis of the Centrifugal Microencapsulation Process

Physical Analysis of the Centrifugal Microencapsulation Process

Data-driven kinematics-consistent model-order reduction of fluid–structure interaction problems: application to deformable microcapsules in a Stokes flow

Capsaicin microcapsules with high encapsulation efficiency and storage stability based on sodium caseinate–acetylated wheat starch: preparation and characterisation

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