Recent progress in solid-state NMR studies of drugs confined within drug delivery systems

Skorupska, Ewa; Jeziorna, Agata; Kaźmierski, Sławomir; Potrzebowski, Marek J.

doi:10.1016/j.ssnmr.2013.12.001

Cited by 49 publications

(77 citation statements)

References 51 publications

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“…The recent advancement of nanomaterials and nanotechnology in the field of medical research has spurred a great interest in so‐called “nanomedicine” . This scientific area embraces a myriad of nanosystems whose diverse applications include monitoring techniques, early diagnostic, therapeutics, and new drug delivery and release protocols . Nanomaterials studied for nanomedicine include mesoporous silicates, polymers, proteins, drug complexes, liposomes and micelles, dendrimers, emulsions, nanocrystals, carbon nanoplatforms, and quantum dots …”

Section: Interfaces In Nanomedicine Complexesmentioning

confidence: 99%

“…In these systems, medicines are formulated into multicomponent nanocomposites containing both APIs and various excipients acting as carriers. The interactions between the drug and the carrier are of great importance: they are the underlying factors that affect the releasing mechanisms, timing, route, and effectiveness of the treatment . In addition, both the API and excipients may undergo a variety of physical and/or chemical changes during production processes, such as granulation, grinding, milling, tablet compression, and drying .…”

Section: Interfaces In Nanomedicine Complexesmentioning

confidence: 99%

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Understanding Surface and Interfacial Chemistry in Functional Nanomaterials via Solid‐State NMR

et al. 2017

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Surface and interfacial chemistry is of fundamental importance in functional nanomaterials applied in catalysis, energy storage and conversion, medicine, and other nanotechnologies. It has been a perpetual challenge for the scientific community to get an accurate and comprehensive picture of the structures, dynamics, and interactions at interfaces. Here, some recent examples in the major disciplines of nanomaterials are selected (e.g., nanoporous materials, battery materials, nanocrystals and quantum dots, supramolecular assemblies, drug-delivery systems, ionomers, and graphite oxides) and it is shown how interfacial chemistry can be addressed through the perspective of solid-state NMR characterization techniques.

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Section: Interfaces In Nanomedicine Complexesmentioning

confidence: 99%

Section: Interfaces In Nanomedicine Complexesmentioning

confidence: 99%

Understanding Surface and Interfacial Chemistry in Functional Nanomaterials via Solid‐State NMR

et al. 2017

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“…Communications more about the structure,w hich can be linked to sometimes unusual in vitro observations. Solid-state NMR spectroscopy has previously been used to characterize drugs within various delivery systems, [9] but an analysis of the changes in the drug delivery system aresult of the drug itself has not been undertaken. In this study,1Dand 2D solid-state NMR spectroscopy yielded insight into the internal structure and dynamics of the micelles.Acomparison of the 13 CNMR spectra of Phen-Pt and freeze-dried HL micelles (Figure 4a-c) shows that upon conjugation the 13 CNMR signals for Phen-Pt are significantly broadened compared to the well-resolved 13 CNMR spectrum for the crystalline Phen-Pt.…”

Section: Angewandte Chemiementioning

confidence: 99%

The Effect of Drug Loading on Micelle Properties: Solid‐State NMR as a Tool to Gain Structural Insight

et al. 2017

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The present study highlights the importance of understanding the structural changes of micelles induced by drug loading on their physico-chemical properties.Ablock copolymer with attached fructose,whichinteracts with GLUT5 receptor,w as used and conjugated with al ow and ah igh amount of platinum drugs.A gainst expectations,t he lowloading micelle,despite having aless defined morphology and larger nanoparticle sizea ccording to TEM, displays higher cellular uptake and higher toxicity.This behaviour can only be understood when elucidating additional information on the structure of micelles.Extensive solid-state NMR measurements were therefore employed to reveal that the drug loading affected swelling and mobility of core and shell of the micelle. The results obtained from solid-state NMR spectroscopycould explain all the observations on this system. In summary,solidstate NMR spectroscopyisa ne xcellent tool to understand the effects of drug loading on the behavior of micelles.Polymermicellesarewidelyappliedasnanocarriersfordrug delivery. [1] Shape,size,and surface functionalization [2] are the primary design factors that are considered for controlling the nanoparticle-cell interactions.Self-assembled polymer nanoparticles (PNs) used as delivery vehicles for anti-cancer drugs overcome some of the drawbacks exhibited by free anticancer drugs such as poor/non-specificity,l ow solubility,t he requirement for high drug concentration within the tissue,and toxicity limited dosage. [3] PNs can improve drug stability, solubility,b iodistribution and specificity,p rolong circulating half-life,exert an enhanced permeation and retention (EPR) effect, and enable controlled triggered release of the drug payload. [4] Theu pshot is that PNs allow the use of ar educed drug dose and therefore minimize the debilitating side effects of anti-cancer drugs.Arange of nanoparticles for drug delivery purposes are available,including highly popular micelles. [5] It is implicitly assumed that polymeric micelles have welldefined core-shell morphology and their bioactivity and cellular uptake are primarily dependent on external parameters such as nanoparticle size,s hape,a nd surface chemistry. [2,6] Thee ffect of drug loading on the morphology and molecular dynamics of the micellar drug carrier,and thus the biological activity,has so far been neglected in the literature, although afew reports suggest that drug loading can enhance the stability of the micelle against disassembly. [7] There is also ac ommon assumption that researchers need to strive for ah igh drug loading to yield the best possible efficacy. However,l ittle attention is given to the effect of the amount of drug loading on the physico-chemical changes in the core and shell of nanoparticles.Herein, we apply an analytical tool, solid-state NMR spectroscopy,t oh elp understand how drug loading and the amount of drug can influence the properties of the nanoparticle,w hich can furthermore affect their behavior in ab iological setting.K nowledge of the internal structure of the m...

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“…This analytical superiority has recently increased the utilization of SS‐NMR in mechanistically understanding the structural features of a variety of complex drug delivery systems including ASD and in relating the same to the physical stability of the products . Very recently, Skorupska et al published a compilation of case studies reflecting the application of SS‐NMR for the characterization of a wide diversity of enabling drug delivery systems, namely, mesoporous silica‐based systems, polymeric dispersions, cyclodextrin complexes, and so on. This review covers different SS‐NMR methodologies with several case studies that provide readers with general insights on the utility of these techniques for the in‐depth elucidation of the phase structures and dynamics of ASD.…”

Section: Amorphous Solid Dispersionmentioning

confidence: 99%

Structural and Dynamic Properties of Amorphous Solid Dispersions: The Role of Solid-State Nuclear Magnetic Resonance Spectroscopy and Relaxometry

Paudel

Geppi

Mooter

2014

Journal of Pharmaceutical Sciences

116

103

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Recent progress in solid-state NMR studies of drugs confined within drug delivery systems

Cited by 49 publications

References 51 publications

Understanding Surface and Interfacial Chemistry in Functional Nanomaterials via Solid‐State NMR

Understanding Surface and Interfacial Chemistry in Functional Nanomaterials via Solid‐State NMR

The Effect of Drug Loading on Micelle Properties: Solid‐State NMR as a Tool to Gain Structural Insight

Structural and Dynamic Properties of Amorphous Solid Dispersions: The Role of Solid-State Nuclear Magnetic Resonance Spectroscopy and Relaxometry

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