2017
DOI: 10.1002/ange.201701471
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The Effect of Drug Loading on Micelle Properties: Solid‐State NMR as a Tool to Gain Structural Insight

Abstract: The present study highlights the importance of understanding the structural changes of micelles induced by drug loading on their physico-chemical properties.Ablock copolymer with attached fructose,whichinteracts with GLUT5 receptor,w as used and conjugated with al ow and ah igh amount of platinum drugs.A gainst expectations,t he lowloading micelle,despite having aless defined morphology and larger nanoparticle sizea ccording to TEM, displays higher cellular uptake and higher toxicity.This behaviour can only be… Show more

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Cited by 31 publications
(25 citation statements)
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“…This drug–corona interaction can enable to ultra‐high drug loading or lead to colloidal instability of the formulation . However, the drug corona interaction can also affect the morphology, endocytosis, or prolong supersaturation . Interestingly, for the POx/POzi nanoformulations the drug was found fully amorphous in the precipitate, which also contains polymer .…”
Section: Resultsmentioning
confidence: 99%
“…This drug–corona interaction can enable to ultra‐high drug loading or lead to colloidal instability of the formulation . However, the drug corona interaction can also affect the morphology, endocytosis, or prolong supersaturation . Interestingly, for the POx/POzi nanoformulations the drug was found fully amorphous in the precipitate, which also contains polymer .…”
Section: Resultsmentioning
confidence: 99%
“…The particle size of the micelles increased slightly after drug loading due to the drug filling. The possible cause is that the degree of aggregation of the hydrophobic portion of the calixarene is slightly reduced due to the entry of the drug into the hydrophobic core of the micelle (Callari et al, 2017). This can also be reflected in the TEM photo (Figure 5).…”
Section: Discussionmentioning
confidence: 99%
“…[1][2][3] Specific examples of commercial application areas include consumer cleaning products, oil recovery, 4 and drug delivery. 5,6 Commercial mixture properties that depend on amphiphile aggregate structure and dynamics include viscosity, [7][8][9][10] foaming, 11 and the ability to suspend and deliver solubilized materials like flavors, fragrances, 12,13 and drugs. 14,15 Amphiphile aggregate based materials are often empirically designed to create and exploit these properties.…”
Section: Introductionmentioning
confidence: 99%