Recent Progress in Synthesis and Functionalization of Multimodal Fluorescent-Magnetic Nanoparticles for Biological Applications

García, Raquel Serrano; Stafford, Shelley; Gun’ko, Yurii K.

doi:10.3390/app8020172

Cited by 57 publications

(16 citation statements)

References 98 publications

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“…Since the coining of the term “magic bullet” by Paul Elrich in 1906 [ 61 ], significant research milestones have been reached in designing and developing targeted nanotherapeutics geared for enhanced and site-specific delivery [ 9 , 62 ]. An essential advantage of using iron-oxide-based NPs is the ease of preparation and functionalisation for tailored specificity [ 63 ].…”

Section: Iron Oxide Nanoparticles In Cancer Diagnostics and Therapymentioning

confidence: 99%

Advances in the Synthesis and Application of Magnetic Ferrite Nanoparticles for Cancer Therapy

et al. 2022

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Cancer is among the leading causes of mortality globally, with nearly 10 million deaths in 2020. The emergence of nanotechnology has revolutionised treatment strategies in medicine, with rigorous research focusing on designing multi-functional nanoparticles (NPs) that are biocompatible, non-toxic, and target-specific. Iron-oxide-based NPs have been successfully employed in theranostics as imaging agents and drug delivery vehicles for anti-cancer treatment. Substituted iron-oxides (MFe2O4) have emerged as potential nanocarriers due to their unique and attractive properties such as size and magnetic tunability, ease of synthesis, and manipulatable properties. Current research explores their potential use in hyperthermia and as drug delivery vehicles for cancer therapy. Significantly, there are considerations in applying iron-oxide-based NPs for enhanced biocompatibility, biodegradability, colloidal stability, lowered toxicity, and more efficient and targeted delivery. This review covers iron-oxide-based NPs in cancer therapy, focusing on recent research advances in the use of ferrites. Methods for the synthesis of cubic spinel ferrites and the requirements for their considerations as potential nanocarriers in cancer therapy are discussed. The review highlights surface modifications, where functionalisation with specific biomolecules can deliver better efficiency. Finally, the challenges and solutions for the use of ferrites in cancer therapy are summarised.

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Section: Iron Oxide Nanoparticles In Cancer Diagnostics and Therapymentioning

confidence: 99%

Advances in the Synthesis and Application of Magnetic Ferrite Nanoparticles for Cancer Therapy

et al. 2022

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“…Here, we present a comprehensive analysis of PL properties of the commonly used CdSe-based QDs and QD-SPION magneto-luminescent composites, which are the most popular systems for tracking analysis and hyperthermia in living cells [ 33 , 34 , 35 , 36 , 37 ]. These nanostructured objects have been selected due to (i) their typical behavior in living cells, i.e., their uptake, toxicity, and intracellular localization in cells; (ii) the well-developed and specified synthetic protocols for QDs and SPIONs; and (iii) a typical approach for the composite development of QD-based hybrid structures, i.e., using stabilizing molecules, particularly L-cysteine, on the QD surface as a linker for creation chemical bonds between QDs and SPIONs.…”

Section: Introductionmentioning

confidence: 99%

Time- and Spectrally-Resolved Photoluminescence Study of Alloyed CdxZn1−xSeyS1−y/ZnS Quantum Dots and Their Nanocomposites with SPIONs in Living Cells

Matiushkina

Литвинов

Bazhenova

et al. 2022

IJMS

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Magnetic-luminescent composites based on semiconductor quantum dots (QDs) and superparamagnetic iron oxide nanoparticles (SPIONs) can serve as a platform combining visualization and therapy. Here, we report the construction of QD-SPION nanocomposites based on synthesized SPIONs and alloyed QDs (CdxZn1−xSeyS1−y)/ZnS solubilized with L-cysteine molecules. The study of the spectral-luminescence characteristics, the kinetics of luminescence decay show the composite’s stability in a solution. After incubation with HeLa cells, QDs, SPIONs, and their composites form clusters on the cell surface and associate with endosomes inside the cells. Component-wise analysis of the photoluminescence decay of cell-associated QDs/SPIONs provides information about their localization and aggregate status.

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“…In several preclinical studies, the fluorescently-labelled MNP have been used not only to understand the localization in target cells, but also to assess their biodistribution in vivo [7]. For these purposes, dyes and iron oxide cores have been encapsulated into a polymer matrix; alternatively, the dye has been attached to the MNP core or at its surface coating [8]. Such studies have been conducted with the assumption that the fluorescence label accurately reflects the MNP localization in the body and that the fluorescence intensity in the region of interest actually correlates with the amount of MNP.…”

Section: Introductionmentioning

confidence: 99%

Challenges in Tracking of Fluorochrome-Labelled Nanoparticles in Mice via Whole Body NIRF Imaging

Gaffron

Tilch

Grüttner³

et al. 2020

Nanomaterials

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Fluorochrome-labelled iron oxide magnetic nanoparticles (MNP) have been of great help in elucidating biological processes. Here, we used dually-fluorochrome-labelled MNP and studied to what extent fluorescence detection could reflect their fate in living animals. One day after application in mice (200 µmol Fe/kg body weight), the fluorescence of the dye attached to the core (DY-730) was very prominent and in agreement with the increase of iron in the liver and spleen of mice, but inconspicuous at time points thereafter. We attribute this fluorescence behavior to early degradation processes of the MNP´s core in the cellular lysosomal compartment. In contrast, the fluorescence of the dye DY-555 stuck to the PEG coating was not detectable in vivo. In summary, labelling of MNP with dyes at their metallic core could be of help when detecting first incidences of MNP biodegradation in vivo, as opposed to dyes attached to the MNP coating.

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Recent Progress in Synthesis and Functionalization of Multimodal Fluorescent-Magnetic Nanoparticles for Biological Applications

Cited by 57 publications

References 98 publications

Advances in the Synthesis and Application of Magnetic Ferrite Nanoparticles for Cancer Therapy

Advances in the Synthesis and Application of Magnetic Ferrite Nanoparticles for Cancer Therapy

Time- and Spectrally-Resolved Photoluminescence Study of Alloyed CdxZn1−xSeyS1−y/ZnS Quantum Dots and Their Nanocomposites with SPIONs in Living Cells

Challenges in Tracking of Fluorochrome-Labelled Nanoparticles in Mice via Whole Body NIRF Imaging

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