Recent progress in the construction and applications of metal-organic frameworks and covalent-organic frameworks-based nanozymes

Multifunctional Nanoprobe-Amplified Enzyme-Linked Immunosorbent Assay on Capillary: A Universal Platform for Simple, Rapid, and Ultrasensitive Dual-Mode Pathogen Detection

“…Recently, the inclusion of functional nanomaterials with unique optical, magnetic, electronic, and catalytic properties has been exploited for signal amplification in ELISA, which has led to better performance with a lower limit of detection (LOD) and other benefits. − First, these nanomaterials can act as enzyme mimetics (nanozymes) to replace natural enzymes in ELISA, which has revolutionized the field of clinical diagnosis. , Many research studies have shown that nanozymes offer significant advantages compared to natural enzymes, including low costs, facile preparation, easy labeling, improved stability under ambient conditions, and easy regulation of composition and structure. , Up to now, a lot of nanozymes such as noble metal, metal oxide/sulfide, , carbon materials, and metal organic frameworks (MOFs) have been successfully developed in recent years. Among them, Fe 3 O 4 magnetic nanoparticles (NPs), the first nanozyme discovered in 2007, were the most popular and prominent enzyme substitute because the unique magnetic property of Fe 3 O 4 NPs offers additional enrichment capacity for target purification in complex matrices and shows excellent compatibility with ELISA .…”

“…26,27 Many research studies have shown that nanozymes offer significant advantages compared to natural enzymes, including low costs, facile preparation, easy labeling, improved stability under ambient conditions, and easy regulation of composition and structure. 28,29 Up to now, a lot of nanozymes such as noble metal, 30 metal oxide/ sulfide, 31,32 carbon materials, 33 and metal organic frameworks (MOFs) 34 have been successfully developed in recent years. Among them, Fe 3 O 4 magnetic nanoparticles (NPs), the first nanozyme discovered in 2007, were the most popular and prominent enzyme substitute because the unique magnetic property of Fe 3 O 4 NPs offers additional enrichment capacity for target purification in complex matrices and shows excellent compatibility with ELISA.…”

“Three-in-one” platform based on Fe-CDs nanozyme for dual-mode/dual-target detection and NIR-assisted bacterial killing

“…4 Since the first reported nanozyme of Fe 3 O 4 nanoparticles (NPs) with peroxidase (POD)-like activity in 2007, 5 various nanozymes that mimic the activities of transferases, hydrolases, lyases, oxidoreductases and isomerase have been reported. [6][7][8][9][10] In particular, POD-like nanozymes have received wide interest in biosensing, bioremediation and therapy thanks to their unique catalytic ability to produce OH with high reactivity in the presence of hydrogen peroxide (H 2 O 2 ). [11][12][13][14] Also, diverse metal-based, metaloxide, sulfide-based and carbon-based nanozymes, as well as metal-organic frameworks (MOFs) and derivatives-based nanozymes have been explored extensively.…”

Highly pH-stable lanthanide MOFs: a tunable luminescence and ratiometric luminescent probe for sulfamethazine

“…Metal-organic frameworks (MOFs) are prominent types of crystalline functional materials made up of metal ions and organic linkers, and have significant applications in fields such as sorption, magnetism, catalysis, separation, sensing, proton conduction, etc. [1][2][3][4][5][6][7][8][9][10][11][12][13] As a subfamily of MOFs, lanthanide-based MOFs (Ln-MOFs) have extraordinary structures and luminous properties due to the flexible variations of Ln 3+ ions in their coordination number and connectivity. Ln-MOFs have been recognized as potential luminescent probes and multicolor tunable luminescent materials due to their advantages of a large Stokes shift, long-lived, vivid and visible luminous color and exceptional luminous monochromaticity.…”

“…Herein, an F atom modified diphosphonic acid ligand H 4 L (H 4 L = 4-F-C 6 H 4 CH 2 N(CH 2 PO 3 H 2 ) 2 ) containing a π-electron conjugation system and oxalic acid (H 2 C 2 O 4 ) as an organic linker were employed to prepare new isomorphic Ln-MOFs [Ln(H 3 L)(C 2 O 4 )]•2H 2 O (Ln = Eu (1), Gd (2), and Tb (3)). Furthermore, six bimetallic or trimetallic doped Ln-MOFs Eu x Tb 1−x (x = 0.02 (4), 0.04 (5), and 0.06 (6)), Gd 0.94 Eu 0.06 (7), Gd 0.96 Tb 0.04 (8) and Gd 0.95 Tb 0.03 Eu 0.02 (9) were obtained by adjusting the molar ratio of Eu 3+ , Gd 3+ , and Tb 3+ in the abovementioned reactions, which realizes the tuning of emission color. In addition, 3 can be employed as a ratiometric luminescent sensor of SMZ with high selectivity and sensitivity.…”