Recent progress in the engineering of multifunctional colloidal nanoparticles for enhanced photodynamic therapy and bioimaging

Lamch, Łukasz; Pucek, Agata; Kulbacka, Julita; Chudy, M.; Jastrzębska, Elżbieta; Tokarska, Katarzyna; Bułka, Magdalena; Brzózka, Zbigniew; Wilk, Kazimiera A.

doi:10.1016/j.cis.2018.09.002

Cited by 64 publications

(48 citation statements)

References 170 publications

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“…Considered as simple drug carrier in most works, nanoparticles are presently designed to achieve several functions [Mura et al, 2013, Mura and Couvreur 2016a, Lamch et al, 2018, Hu et al, 2018.…”

Section: Bypassing the Cell Membrane Of Multidrug Resistant Cancer Cellsmentioning

confidence: 99%

“…Most ongoing clinical trials concern treatments of various cancers caused by solid tumors. In general, nanomedicines are developed as drug delivery systems, but several projects concern nanomaterials to be used in cancer radiotherapy [Hainfeld et al, 2014, Mi et al, 2016, Lacombe et al, 2017, Lamch et al, 2018. Beside treating cancers and infections, nanomedicines hold promise to improve the life of patients suffering from brain diseases [Andrieux and Couvreur, 2013, Kreuter, 2014, Savaira et al, 2016, Zhou et al, 2018, cardiovascular diseases [Ferreira et al, 2015, Suarez et al, 2015, Varna et al, 2015, Chan et al, 2018, Cicha et al, 2018, Dormont et al, 2018 and metabolic diseases [Pridgen et al, 2015, Aguirre et al, 2016, Wong et al, 2017.…”

Section: Introductionmentioning

confidence: 99%

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A journey through the emergence of nanomedicines with poly(alkylcyanoacrylate) based nanoparticles

Vauthier

2019

Journal of Drug Targeting

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Starting in the late 1970s, the pioneering work of Patrick Couvreur gave birth to the first biodegradable nanoparticles composed of a biodegradable synthetic polymer. These nanoparticles, made of poly(alkylcyanoacrylate) (PACA), were the first synthetic polymer based nanoparticulate drug carriers undergoing a phase III clinical trial so far. Analyzing the journey from the birth of PACA nanoparticles to their clinical evaluation, the paper highlights their remarkable adaptability to bypass various drug delivery challenges found on the way. At present, PACA nanoparticles includes a wide range of nanoparticles that can associate drugs of different chemical nature and be administered in vivo by different routes. The most recent technologies giving the nanoparticles customized functions could also be implemented on this family of nanoparticles. Through different examples, the paper discusses the seminal role of the PACA nanoparticles' family in the development of nanomedicines.

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Section: Bypassing the Cell Membrane Of Multidrug Resistant Cancer Cellsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A journey through the emergence of nanomedicines with poly(alkylcyanoacrylate) based nanoparticles

Vauthier

2019

Journal of Drug Targeting

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“…However, as reported by Zhang et al in a recent review [18], clinical development of PDT remains somewhat limited because of various challenges, ranging from photosensitizer formulation, light dosimetry, to planning and monitoring the treatment [15,[18][19][20][21][22]. Some of these points have been recently reviewed: ideal photosensitizers [23], challenges in formulating photosensitizers, and choosing the right light dosimetry [24], as well as monitoring the treatment response [25]. Among all these, the adaptation of light source and dosimetry is currently a very active field.…”

Section: Introductionmentioning

confidence: 99%

Rational design of block copolymer self-assemblies in photodynamic therapy

Demazeau¹,

Gibot²,

Mingotaud³

et al. 2020

Beilstein J. Nanotechnol.

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Photodynamic therapy is a technique already used in ophthalmology or oncology. It is based on the local production of reactive oxygen species through an energy transfer from an excited photosensitizer to oxygen present in the biological tissue. This review first presents an update, mainly covering the last five years, regarding the block copolymers used as nanovectors for the delivery of the photosensitizer. In particular, we describe the chemical nature and structure of the block copolymers showing a very large range of existing systems, spanning from natural polymers such as proteins or polysaccharides to synthetic ones such as polyesters or polyacrylates. A second part focuses on important parameters for their design and the improvement of their efficiency. Finally, particular attention has been paid to the question of nanocarrier internalization and interaction with membranes (both biomimetic and cellular), and the importance of intracellular targeting has been addressed.

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“…The work reported here extends our studies on new methodologies and techniques regarding biopharmaceuticals and new biocompatible drug nanocarriers. 25 − 29 In the present contribution, horseweed has been selected as a source of plant-originated functional food fiber. Moreover, its easy availability and the fact that this weed is a common issue in agriculture draw attention to the need for development of this valuable bioresource.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Ultrasound-Assisted Extraction of Functional Food Fiber from Canadian Horseweed (Erigeron canadensis L.)

et al. 2020

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Much attention has been recently paid to the design of sustainable processes for the production of functional food additives based on renewable resources. Thus, methods for incorporation of green techniques in treatment of undeveloped biomass, resulting in value-added bioproducts, are in great demand. We focus here on the biological activity and chemical properties of Erigeron canadensis (horseweed) functional food fiber, which can be strongly affected by the extraction procedure employed. In the present contribution, we report on an attempt to introduce a sustainable and energy-efficient ultrasound-assisted extraction process, followed by a multistep purification procedure, resulting in a macromolecular plant-derived anticoagulant agent. The most efficient ultrasound-assisted process was determined by optimization through the response surface methodology I -optimal design (2 4 ). A comparison with the conventional procedure for retrieval of horseweed biomacromolecules revealed that the optimized ultrasound-assisted extraction was more sustainable, with the cumulative energy demand being 38% lower (12.2 MJ), 6.6 times reduced water consumption (3.5 L), and 1.2 times shorter (41 h) total processing time. Moreover, the optimal ultrasound-assisted extraction process-purified food fiber turned out to be a better anticoagulant agent by 57%, compared to a conventional product, and was a more selective indirect inhibitor of the human Xa coagulation factor.

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Recent progress in the engineering of multifunctional colloidal nanoparticles for enhanced photodynamic therapy and bioimaging

Cited by 64 publications

References 170 publications

A journey through the emergence of nanomedicines with poly(alkylcyanoacrylate) based nanoparticles

A journey through the emergence of nanomedicines with poly(alkylcyanoacrylate) based nanoparticles

Rational design of block copolymer self-assemblies in photodynamic therapy

Optimization of Ultrasound-Assisted Extraction of Functional Food Fiber from Canadian Horseweed (Erigeron canadensis L.)

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