Recent Progress of Fabrication of Cell Scaffold by Electrospinning Technique for Articular Cartilage Tissue Engineering

Zhou, Yingge; Chyu, Joanna; Zumwalt, Mimi

doi:10.1155/2018/1953636

Cited by 53 publications

(30 citation statements)

References 70 publications

(91 reference statements)

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“…Moreover, the problem of obtaining a 3D structure with suitable pore size is considered as a main disadvantage of this technique. Importantly, electrospinning does not require the use of high temperature [19,196,216,221,225]. It is worth underlining that fabrication of proteins-based biomaterials should be performed under mild conditions.…”

Section: Application Of Polymer Scaffolds Modified With Proteins and mentioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, and cytokines. Although there are many papers describing synthesis and properties of polymer scaffolds enriched with proteins or peptides, few reviews comprehensively summarize these bioactive molecules. Thus, this review presents the current knowledge about the most important proteins and peptides used for modification of polymer scaffolds for tissue engineering. This paper also describes the influence of addition of proteins and peptides on physicochemical, mechanical, and biological properties of polymer scaffolds. Moreover, this article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.

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Section: Application Of Polymer Scaffolds Modified With Proteins and mentioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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“…Several others demonstrated the feasibility of electrospun scaffolds in engineering various tissues such as cartilage, cornea, liver, etc. [29,30].…”

Section: Electrospun Matrices In Tissue Engineeringmentioning

confidence: 99%

Strategies to Tune Electrospun Scaffold Porosity for Effective Cell Response in Tissue Engineering

Ameer

Kasoju

2019

JFB

125

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Tissue engineering aims to develop artificial human tissues by culturing cells on a scaffold in the presence of biochemical cues. Properties of scaffold such as architecture and composition highly influence the overall cell response. Electrospinning has emerged as one of the most affordable, versatile, and successful approaches to develop nonwoven nano/microscale fibrous scaffolds whose structural features resemble that of the native extracellular matrix. However, dense packing of the fibers leads to small-sized pores which obstruct cell infiltration and therefore is a major limitation for their use in tissue engineering applications. To this end, a variety of approaches have been investigated to enhance the pore properties of the electrospun scaffolds. In this review, we collect state-of-the-art modification methods and summarize them into six classes as follows: approaches focused on optimization of packing density by (a) conventional setup, (b) sequential or co-electrospinning setups, (c) involving sacrificial elements, (d) using special collectors, (e) post-production processing, and (f) other specialized methods. Overall, this review covers historical as well as latest methodologies in the field and therefore acts as a quick reference for those interested in electrospinning matrices for tissue engineering and beyond.

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“…These are superior to natural scaffolds in that their mechanical strength and crystallinity can be varied during manufacture along with the rate at which they undergo degradation ( Gunatillake et al, 2003 ; Kundu et al, 2013 ). Furthermore, with newer techniques such as electrospinning and 3D printing, scaffold porosity, and shape are easily modifiable and constructed based on the requirement ( Woodfield et al, 2005 ; Li et al, 2007 ; Thorvaldsson et al, 2008 ; Duan et al, 2014 ; Zhou et al, 2018 ). The major drawback of synthetic scaffolds is their poor bioactivity owing to their hydrophobic surfaces hindering cellular attachment ( Bhattarai et al, 2006 ; Lee et al, 2006 ).…”

Section: Scaffoldsmentioning

confidence: 99%

Osteochondral Injury, Management and Tissue Engineering Approaches

Jacob

Shimomura

Nakamura

2020

Front. Cell Dev. Biol.

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Osteochondral lesions (OL) are a common clinical problem for orthopedic surgeons worldwide and are associated with multiple clinical scenarios ranging from trauma to osteonecrosis. OL vary from chondral lesions in that they involve the subchondral bone and chondral surface, making their management more complex than an isolated chondral injury. Subchondral bone involvement allows for a natural healing response from the body as marrow elements are able to come into contact with the defect site. However, this repair is inadequate resulting in fibrous scar tissue. The second differentiating feature of OL is that damage to the subchondral bone has deleterious effects on the mechanical strength and nutritive capabilities to the chondral joint surface. The clinical solution must, therefore, address both the articular cartilage as well as the subchondral bone beneath it to restore and preserve joint health. Both cartilage and subchondral bone have distinctive functional requirements and therefore their physical and biological characteristics are very much dissimilar, yet they must work together as one unit for ideal joint functioning. In the past, the obvious solution was autologous graft transfer, where an osteochondral bone plug was harvested from a non-weight bearing portion of the joint and implanted into the defect site. Allografts have been utilized similarly to eliminate the donor site morbidity associated with autologous techniques and overall results have been good but both techniques have their drawbacks and limitations. Tissue engineering has thus been an attractive option to create multiphasic scaffolds and implants. Biphasic and triphasic implants have been under explored and have both a chondral and subchondral component with an interface between the two to deliver an implant which is biocompatible and emulates the osteochondral unit as a whole. It has been a challenge to develop such implants and many manufacturing techniques have been utilized to bring together two unalike materials and combine them with cellular therapies. We summarize the functions of the osteochondral unit and describe the currently available management techniques under study.

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Recent Progress of Fabrication of Cell Scaffold by Electrospinning Technique for Articular Cartilage Tissue Engineering

Cited by 53 publications

References 70 publications

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Strategies to Tune Electrospun Scaffold Porosity for Effective Cell Response in Tissue Engineering

Osteochondral Injury, Management and Tissue Engineering Approaches

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