Recent Progress of Nanozymes in the Detection of Pathogenic Microorganisms

Sun, Huiyuan; Cai, Shuangfei; Wang, Chen; Chen, Yong-Xiang; Yang, Rong

doi:10.1002/cbic.202000126

Cited by 21 publications

(8 citation statements)

References 131 publications

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“…Nanozymes have been widely employed for the detection of CDs. [100] Recent examples include AuNP decorated 2D metalorganic frameworks (MOFs) for the electrochemical detection of pathogenic Staphylococcus aureus; [101] aqueous two-phase system to concentrate and purify samples in combination with Pt-NCs for the colorimetric detection of the malaria biomarker Plasmodium lactate dehydrogenase in human serum; [102] and PtNCs to perform a nanozyme linked immunochromatographic sensor for the detection of SARS-CoV-2 nucleocapsid protein in the blood. [103] Although PoC devices were initially thought to be most advantageous for the detection of CDs, they have been widely applied to the detection of NCDs as well.…”

Section: Considerations For Communicable Diseases (Cds)mentioning

confidence: 99%

The Nanozyme Revolution: Enhancing the Performance of Medical Biosensing Platforms

et al. 2023

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Nanozymes represent a class of nanosized materials that exhibit innate catalytic properties similar to biological enzymes. The unique features of these materials have positioned them as promising candidates for applications in clinical sensing devices, specifically those employed at the point‐of‐care. They notably have found use as a means to amplify signals in nanosensor‐based platforms and thereby improve sensor detection limits. Recent developments in the understanding of the fundamental chemistries underpinning these materials have enabled the development of highly effective nanozymes capable of sensing clinically relevant biomarkers at detection limits that compete with “gold‐standard” techniques. However, there remain considerable hurdles that need to be overcome before these nanozyme‐based sensors can be utilized in a platform ready for clinical use. An overview of the current understandings of nanozymes for disease diagnostics and biosensing applications and the unmet challenges that must be considered prior to their translation in clinical diagnostic tests is provided.

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Section: Considerations For Communicable Diseases (Cds)mentioning

confidence: 99%

The Nanozyme Revolution: Enhancing the Performance of Medical Biosensing Platforms

et al. 2023

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“…Furthermore, using nanozyme probes as nanoparticles, strips, nanocomposites, bioconjugates, and nano-complexes has contributed significantly to the fabrication of sensitive tests for pathogen diagnosis based on fast visual and colorimetric changes. 27 For instance, nanozyme biosensors based on Au nanoparticles were developed for avian influenza virus H5N1, 28 and murine norovirus (MNV) recognition through peroxidase-like Au nanoparticle aptasensors. 29 Recently, Meng.…”

Section: Current Status In Advancing Biosensing Devices For Respirato...mentioning

confidence: 99%

Anticipating Challenges in Optical Nanobiosensors for Global Detection of Respiratory Viruses and Emerging Threats

Martínez Tolibia,

Galdámez-Martínez,

Salinas

et al. 2023

ECS Sens. Plus

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The unprecedented SARS-CoV-2 pandemic has opened huge opportunities for nanomaterial-based biosensors focused on timely detection of emerging respiratory viruses, where challenges must address actions for fast response and massive application. Accordingly, we provide a comprehensive perspective on critical aspects, including nanomaterials, biofunctionalization strategies, and bioreceptors engineering to increase accuracy, emphasizing optical nanobiosensors. The first biosensing prototype performance reveals the need to consider crucial factors for improvement, such as handling detection in complex matrices, standardization for commercial purposes, portability, integration with artificial intelligence, sustainability, and economic feasibility. By achieving these goals, biosensors would foster a prepared global healthcare landscape.

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“…For instance, cerium oxide nanoparticles are used to monitor superoxide dismutase- and catalase-mimic activities, whereas ferric-based nanoparticles detect peroxidase- and oxidase-mimic actions (Yang et al 2017 ; Bhagat et al 2018 ). Nanomaterials have been used for the detection of glucose, cholesterol, organophosphorous neurotoxins, DNA, c-reactive proteins, viruses, stem cell, and cancer cells (Liang et al 2013 ; Maji et al 2015 ; Nirala et al 2018 ; Jansman and Hosta-Rigau 2019 ; Sun et al 2020 ; Gupta et al 2021 ). Signals are detected and imaged using properties such as electrochemical, chemiluminescence, fluorescence, calorimetry, surface plasmon resonance and thermoplasmonic.…”

Section: Nanozymes For Detection Of Chemicals Viruses and Cellsmentioning

confidence: 99%

Nanozymes to fight the COVID-19 and future pandemics

et al. 2021

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In 2019, the pandemic induced by the rapid spread of the severe acute respiratory syndrome coronavirus-2 'SARS-CoV-2', also named coronavirus disease 'COVID-19', has rapidly caused serious health, economic, social, and political issues worldwide. This has been accentuated by asymptomatic carriers, fast viral mutations, incoherent lockdown policies, and limited methods of detection and treatment. Nucleic acid tests for COVID-19 are lengthy and complicated, and the rapid antibody tests produce false-negative diagnoses, particularly in the early stage of infection. Moreover, there are no specific and effective medicines available for treatment. Therefore, rapid diagnostics and therapeutics are urgently required. Here, we argue that nanozymesenzyme-mimicking nanoparticles-could be used for faster, more sensitive, and accurate detection and treatment of the COVID-19. Indeed, nanozymes have high surface areas allowing easier bioconjugation for detection, and nanozymes possess integrated drug-functionalization for treatment. Moreover, the size, composition, and surface chemistry of nanozymes can be rationally designed for improved theranostic applications. COVID-19 historyThe COVID-19 appeared in Wuhan, China, due to emergence of a novel strain of coronavirus (Sallard et al. 2021), which was provisionally named '2019-nCoV' by the World Health Organization (WHO). Later, the virus was renamed 'SARS-CoV-2' by the International Committee

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Recent Progress of Nanozymes in the Detection of Pathogenic Microorganisms

Cited by 21 publications

References 131 publications

The Nanozyme Revolution: Enhancing the Performance of Medical Biosensing Platforms

The Nanozyme Revolution: Enhancing the Performance of Medical Biosensing Platforms

Anticipating Challenges in Optical Nanobiosensors for Global Detection of Respiratory Viruses and Emerging Threats

Nanozymes to fight the COVID-19 and future pandemics

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