Recent progress on the chemistry of thieno[3,2‐b]quinoline derivatives (part III)

Abstract

This review describes the methods of preparation and the chemical reactivity of thieno[3,2‐b]quinolines.

Synthesis, Absorption, Distribution, Metabolism, Excretion, Toxicology (ADMET) and molecular docking studies of some pyridin-2(1H)-one derived from a Apocynin in Thi-Qar Governorate

“…The synthesized compounds were characterized by the technology of FTIR spectra using a K-Br disc on Perkin Elmer, tenser 27 (Bruker). In the characterization, 1 H-NMR and 13 C-NMR spectra were used; they were listed on a Bruker-DRX system AL 400 MHz spectrometer with internal standard TMS in Basra.…”

“…The synthesized compounds have been characterization by the determination physical properties as shown in table1 and the spectroscopy methods such as FTIR, 1 H-NMR, 13 C-NMR. The FTIR spectra of compounds T 1 -T 3 showed absorption bands at 3369 , 3375, 3365 cm −1 respectively due to the stretching vibration of OH group and showed absorption bands 3137, 3140, 3138 cm -1 due to the stretching vibration of the N-H also a strong band at 1665,1665, 1657 cm −1 respectively, which is illustrated to stretching vibration of carbonyl group of the heterocyclic six member ring the appearance of bands at 2229 , 2230, 2210 cm −1 refer to the C≡N.…”

“…Some synthetic 2-pyridone intermediates and its metabolites demonstrate a broad spectrum in biological applications [6,8] Naturally 2pyridone derivatives like Rici nine [9] remarkable as CNS stimulant activities and the analogs albamycin [10,12], Some authors consider that biological activity of 3cyanopyridine-2(1 H)-ones depends on the substituent at a nitrogen atom of the pyridinone ring [12] . Some pyridinone derivatives containing aromatic substituents have valuable properties and display a variety of biological activities [13]. In our previous report, we described the synthesis of some substituted 3-cyanopyridine-2(1 H)-ones with various aliphatic substituents at positions 1 and 4 of the pyridinone ring [14].…”

Quinoline N‐Oxide: A Versatile Precursor in Organic Transformations

“…There are also some researchers to use greener method for the synthesis of several quinoline derivatives. Many review articles related to the synthesis of quinolines were published, such as synthesis of derivatives of thieno [2,3-b]quinoline (Part-II) was reviewed by Mohammed A. Salem et al in 2021, [1] synthesis of derivatives of thieno [3,2-b]quinoline derivatives (Part-III) was reviewed in 2021 by Moustafa A. Gouda and team, [2] review article related to preparations of tetrahydrothieno [3,2b]quinolines (Part-IV) was published in 2022 by Ameen A. Abu-Hashem and team, [3] reactions associated with thieno [3,2c]quinolines (Part-V and Part-VI) were reported by Ameen A. Abu-Hashem in 2021 [4] and Moustafa A. Gouda et al in 2022 [5] respectively.…”