Recent progresses in the delivery of β-carotene: From nano/microencapsulation to bioaccessibility

Jalali-Jivan, Mehdi; Rostamabadi, Hadis; Assadpour, Elham; Tomaş, Merve; Çapanoğlu, Esra; Sani, Mahmood Alizadeh; Kharazmi, Mohammad Saeed; Jafari, Seid Mahdi

doi:10.1016/j.cis.2022.102750

Cited by 18 publications

(9 citation statements)

References 125 publications

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“…On the one hand, PS/WP formed a protective layer on the surface of NL, which inhibited the destruction of the membrane by the external environment; on the other hand, the hydrophobic groups of PS/WP inserted into the defective region of the NL bilayer, which reduced the fluidity of the membrane and improved the rigidity of the bilayer membrane (Gomaa et al ., 2017). Moreover, the β‐carotene retention rate at 4 °C was obviously higher than that at 25 °C, and it was consistent with the effect of temperature on β‐carotene oxidation (Jalali‐Jivan et al ., 2022).…”

Section: Resultsmentioning

confidence: 99%

“…β‐carotene, the most ubiquitous natural carotenoid, is a valuable active substance that can effectively improve eyesight, immune system, and cognitive ability, as well as preventing coronary diseases and cancer (Jalali‐Jivan et al ., 2022). However, β‐carotene as a fat‐soluble compound is sensitive to the surroundings, such as oxygen and light; therefore, the inherent low water solubility and poor physicochemical stability limit the application of this active ingredient in food, pharmaceutical, and nutraceutical fields (Achir et al ., 2011; Tanaka et al ., 2020).…”

Section: Introductionmentioning

confidence: 99%

“…However, β‐carotene as a fat‐soluble compound is sensitive to the surroundings, such as oxygen and light; therefore, the inherent low water solubility and poor physicochemical stability limit the application of this active ingredient in food, pharmaceutical, and nutraceutical fields (Achir et al ., 2011; Tanaka et al ., 2020). Delivery systems (such as nanoparticles, microcapsules, and emulsions) were considered as an effective tool for improving the water solubility and physicochemical stability of β‐carotene (Jalali‐Jivan et al ., 2022).…”

Section: Introductionmentioning

confidence: 99%

“…NL as a nanocarrier has been employed to deliver β‐carotene in the food field due to its natural nontoxicity, high biocompatibility, amphipathic properties, and so on (Panja et al ., 2019). However, the encapsulation ability, the retention in gastrointestinal fluid, and the storage stability of β‐carotene‐loaded NL (β‐C NL) still need to be improved (Jalali‐Jivan et al ., 2022). Coating with biomacromolecules (such as polysaccharides and proteins) is considered as a potential strategy to overcome the shortcomings of β‐C NL.…”

Section: Introductionmentioning

confidence: 99%

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Improving the encapsulation of β‐carotene by nanoliposomes via potato starch/whey protein coating

Gu,

Xu,

Pan

et al. 2024

Int J of Food Sci Tech

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SummaryThe ability of nanoliposomes (NLs) to encapsulate β‐carotene synergistically improved via the potato starch (PS)/whey protein (WP) coating was investigated. The encapsulation efficiency of PS‐/WP‐coated NL (SP‐NL) increased to above 80% compared to that of NL, PS‐coated NL, and WP‐coated NL. It manifested that the ability of NL to encapsulate β‐carotene was significantly enhanced after coating with PS/WP. The encapsulation ability of SP‐NL was also influenced by environmental factors (pH, temperature, and ionic strength). Moreover, the storage stability of NL after complexation with PS/WP was effectively enhanced compared to that of NL, PS‐coated NL, and WP‐coated NL. TEM images showed that SP‐NL was fairly spherical, and SP‐NL mainly ranged between 100 nm and 500 nm in size. Zeta‐potential and particle size indicated that the dispersion of SP‐NL was highly stable, and electrostatic forces played a vital role in the stability. Furthermore, the fluorescence polarisation of DPH demonstrated that the decrease in membrane fluidity of NL after PS/WP coating was more obvious from 5.28 to 4.05 compared with that of NL after PS or WP coating, indicating that PS/WP was more effective in increasing the rigidity of the phospholipid layer and improving the structure of the bilayer. The present study suggests that PS/WP coating on NL can be an effective strategy to improve the ability of NL to encapsulate β‐carotene and may provide some theoretical support for the development of an effective delivery system for bioactive substances.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Improving the encapsulation of β‐carotene by nanoliposomes via potato starch/whey protein coating

Gu,

Xu,

Pan

et al. 2024

Int J of Food Sci Tech

View full text Add to dashboard Cite

show abstract

“…The most commonly used delivery systems for carotenoids are oil-in-water emulsions (multilayer emulsions, multiple emulsions), polymer complexes, liposomes, micelle, Pickering emulsions, as well as starch and alginate-based hydrogels [ 20 ]. The best results in encapsulating carotenes were obtained by using micelles, emulsions, liposomes, and polymer complexes [ 21 , 57 , 58 , 59 , 60 , 61 ]. Among lipid-based encapsulating systems, emulsions are particularly suitable for encapsulation and protection of carotenoids.…”

Section: Encapsulationmentioning

confidence: 99%

Alginate Gel-Based Carriers for Encapsulation of Carotenoids: On Challenges and Applications

Milivojević

Popović

Pajić‐Lijaković

et al. 2023

Gels

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Sodium alginate is one of the most interesting and the most investigated and applied biopolymers due to its advantageous properties. Among them, easy, simple, mild, rapid, non-toxic gelation by divalent cations is the most important. In addition, it is abundant, low-cost, eco-friendly, bio-compatible, bio-adhesive, biodegradable, stable, etc. All those properties were systematically considered within this review. Carotenoids are functional components in the human diet with plenty of health benefits. However, their sensitivity to environmental and process stresses, chemical instability, easy oxidation, low water solubility, and bioavailability limit their food and pharmaceutical applications. Encapsulation may help in overcoming these limitations and within this review, the role of alginate-based encapsulation systems in improving the stability and bioavailability of carotenoids is explored. It may be concluded that all alginate-based systems increase carotenoid stability, but only those of micro- and nano-size, as well as emulsion-based, may improve their low bioaccessibility. In addition, the incorporation of other biopolymers may further improve encapsulation system properties. Furthermore, the main techniques for evaluating the encapsulation are briefly considered. This review critically and profoundly explains the role of alginates in improving the encapsulation process of carotenoids, suggesting the best alternatives for those systems. Moreover, it provides a comprehensive cover of recent advances in this field.

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Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds

Zhang,

Ding

et al. 2024

Small

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Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to their own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects of BCs. NCs are equally important as BCs to some extent. Self‐assembly (SA) methods to build NCs have many advantages than chemical methods, and SA has significant impact on the structure and function of NCs. However, the relationship among SA mechanism, structure, and function has not been given enough attention. Therefore, from the perspective of bottom‐up building mechanism, the concept of SA‐structure‐function of NCs is emphasized to promote the development of SA‐based NCs. First, the conditions and forces for occurring SA are introduced, and then the SA basis and molecular mechanism of protein, polysaccharide, and lipid are summarized. Then, varieties of the structures formed based on SA are introduced in detail. Finally, facing the defects of BCs and how to be well solved by NCs are also elaborated. This review attempts to describe the great significance of constructing artificial NCs to deliver BCs from the aspects of SA‐structure‐function, so as to promote the development of SA‐based NCs and the wide application of BCs.

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Recent progresses in the delivery of β-carotene: From nano/microencapsulation to bioaccessibility

Cited by 18 publications

References 125 publications

Improving the encapsulation of β‐carotene by nanoliposomes via potato starch/whey protein coating

Improving the encapsulation of β‐carotene by nanoliposomes via potato starch/whey protein coating

Alginate Gel-Based Carriers for Encapsulation of Carotenoids: On Challenges and Applications

Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds

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