Recent Research Progress in Autism Spectrum Disorder

Yu, Xiang; Qiu, Zilong; Zhang, Dai

doi:10.1007/s12264-017-0117-2

Cited by 8 publications

(2 citation statements)

References 46 publications

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“…A number of critical synaptic proteins have been identified ( Kittel et al, 2006 ; Liu et al, 2011 ; Owald et al, 2012 ; Petzoldt and Sigrist, 2014 ; Waites et al, 2005 ; Wu et al, 2010 ; Yamagata et al, 2003 ). Among those are the heterotypic synaptic adhesion molecules neurexins and neuroligins, which have captured special attention because of their potent synaptogenic properties and their genetic linkage to autism and other mental disorders ( Feng et al, 2006 ; Jamain et al, 2003 ; Kim et al, 2008 ; Laumonnier et al, 2004 ; Lawson-Yuen et al, 2008 ; Tian et al, 2017 ; Yu et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Neurexin–Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction

Xing

Sun

et al. 2018

eLife

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Neuroligins are postsynaptic adhesion molecules that are essential for postsynaptic specialization and synaptic function. But the underlying molecular mechanisms of neuroligin functions remain unclear. We found that Drosophila Neuroligin 1 (DNlg1) regulates synaptic structure and function through WAVE regulatory complex (WRC)-mediated postsynaptic actin reorganization. The disruption of DNlg1, DNlg2, or their presynaptic partner neurexin (DNrx) led to a dramatic decrease in the amount of F-actin. Further study showed that DNlg1, but not DNlg2 or DNlg3, directly interacts with the WRC via its C-terminal interacting receptor sequence. That interaction is required to recruit WRC to the postsynaptic membrane to promote F-actin assembly. Furthermore, the interaction between DNlg1 and the WRC is essential for DNlg1 to rescue the morphological and electrophysiological defects in dnlg1 mutants. Our results reveal a novel mechanism by which the DNrx-DNlg1 trans-synaptic interaction coordinates structural and functional properties at the neuromuscular junction.

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Section: Introductionmentioning

confidence: 99%

Neurexin–Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction

Xing

Sun

et al. 2018

eLife

View full text Add to dashboard Cite

show abstract

“…Autism spectrum disorder (ASD) is a childhood-onset neuropsychiatric disorder that is characterized by deficits in social communication and social interactions, as well as stereotyped, repetitive behaviors and/or restricted interests (American Psychiatric Association, 2013). Global attention has been drawn to ASD due to its apparently growing prevalence, from a global prevalence of 62 in 10,000 to as high as 1 in 68 in the United States (Yu et al, 2017).…”

Section: Introductionmentioning

confidence: 99%